MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Hugo	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 2908 to 2957 of 3228 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1
red  : 0.00001
green  : 0.00001
network_comparison  : 1

Rank	description	Hugo
2908	serine/threonine-protein kinase chk1 (ec 2.7.1.-). [swissprot;acc:o14757]	CHEK1
2909	nk6 transcription factor related, locus 2; nk homeobox family 6, b; glial and testis-specific homeobox protein; homeobox 6b. [refseq;acc:nm_177400]	NKX6-2
2910	protein transport protein sec24c (sec24-related protein c). [swissprot;acc:p53992]	no value
2911	bup protein. [refseq;acc:nm_012071]	COMMD3
2912	inositol polyphosphate-5-phosphatase; phosphatidylinositol polyphosphate 5-phosphatase type iv; phosphatidylinositol (4,5) bisphosphate 5-phosphatase. [refseq;acc:nm_019892]	INPP5E
2913	au rna-binding protein/enoyl-coenzyme a hydratase precursor; au rna-binding protein/enoyl-coenzyme a hydratase; 3-methylglutaconyl-coa hydratase; mga type i. [refseq;acc:nm_001698]	AUH
2914	lactamase, beta 2. [refseq;acc:nm_016027]	LACTB2
2915	mitochondrial solute carrier protein. [refseq;acc:nm_016612]	SLC25A37
2916	ribose-phosphate pyrophosphokinase i (ec 2.7.6.1) (phosphoribosyl pyrophosphate synthetase i) (ppribp) (prs-i). [swissprot;acc:p09329]	PRPS1L1
2917	t-complex protein 1, zeta subunit (tcp-1-zeta) (cct-zeta) (cct-zeta-1) (tcp20) (htr3). [swissprot;acc:p40227]	CCT6A
2918	nipsnap2 protein (glioblastoma amplified sequence). [swissprot;acc:o75323]	GBAS
2919	glycine receptor alpha-1 chain precursor (glycine receptor 48 kda subunit) (strychnine binding subunit). [swissprot;acc:p23415]	GLRA1
2920	glycine receptor alpha-3 chain precursor. [swissprot;acc:o75311]	GLRA3
2921	ell-associated factor 2; uncharacterized bone marrow protein bm040; testosterone regulated apoptosis inducer and tumor suppressor. [refseq;acc:nm_018456]	EAF2
2922	10-formyltetrahydrofolate dehydrogenase (ec 1.5.1.6) (10-fthfdh). [swissprot;acc:o75891]	ALDH1L1
2923	transmembrane protein 4. [refseq;acc:nm_014255]	TMEM4
2924	rcd1 required for cell differentiation1 homolog; protein involved in sexual development; rcd1 (required for cell differentiation, s.pombe) homolog 1. [refseq;acc:nm_005444]	RQCD1
2925	ras-related protein ral-b. [swissprot;acc:p11234]	RALB
2926	dual specificity protein phosphatase 11 (ec 3.1.3.48) (rna/rnp complex-intereracting phosphatase) (phosphatase that interacts with rna/rnp complex 1). [swissprot;acc:o75319]	DUSP11
2927	wd-repeat containing protein ciao 1. [swissprot;acc:o76071]	CIAO1
2928	calmodulin. [swissprot;acc:p02593]	no value
2929	lysosomal trafficking regulator (beige homolog). [swissprot;acc:q99698]	LYST
2930	interleukin enhancer binding factor 2; nuclear factor of activated t-cells, 45-kda. [refseq;acc:nm_004515]	ILF2
2931	tropomyosin alpha 3 chain (tropomyosin 3) (tropomyosin gamma). [swissprot;acc:p06753]	TPM3
2932	pogo transposable element with znf domain isoform 1. [refseq;acc:nm_015100]	POGZ
2933	semaphorin 6c precursor (semaphorin y) (sema y). [swissprot;acc:q9h3t2]	SEMA6C
2934	protoporphyrinogen oxidase (ec 1.3.3.4) (ppo). [swissprot;acc:p50336]	PPOX
2935	putative membrane protein. [refseq;acc:nm_019026]	TMCO1
2936	retinoic acid receptor rxr-gamma. [swissprot;acc:p48443]	RXRG
2937	similar to mob-lak. [refseq;acc:nm_145279]	MOBKL2C
2938	cyr61 protein precursor (cysteine-rich, angiogenic inducer, 61) (insulin-like growth factor-binding protein 10) (gig1 protein). [swissprot;acc:o00622]	CYR61
2939	fibrillin 3. [refseq;acc:nm_032447]	FBN3
2940	transcription factor 4 (immunoglobulin transcription factor 2) (itf-2) (sl3-3 enhancer factor 2) (sef-2). [swissprot;acc:p15884]	no value
2941	transcription initiation factor tfiid 105 kda subunit (tafii-105) (tafii105) (fragment). [swissprot;acc:q92750]	TAF4B
2942	ssxt protein (synovial sarcoma, translocated to x chromosome) (syt protein). [swissprot;acc:q15532]	SS18
2943	phosphoribosyl pyrophosphate synthetase-associated protein 2 (prpp synthetase-associated protein 2) (41 kda phosphoribosypyrophosphate synthetase-associated protein) (pap41). [swissprot;acc:o60256]	PRPSAP2
2944	tigger transposable element derived 7; jerky (mouse) homolog-like. [refseq;acc:nm_033208]	TIGD7
2945	tropomyosin 1 alpha chain (alpha-tropomyosin). [swissprot;acc:p09493]	TPM1
2946	transcription initiation factor iia gamma chain (tfiia p12 subunit) (tfiia-12) (tfiias) (tfiia-gamma). [swissprot;acc:p52657]	GTF2A2
2947	small edrk-rich factor 2. [refseq;acc:nm_005770]	SERF2
2948	transcription factor 12 (transcription factor htf-4) (e-box-binding protein) (dna-binding protein htf4). [swissprot;acc:q99081]	TCF12
2949	microfibrillar-associated protein 1. [swissprot;acc:p55081]	MFAP1
2950	bax inhibitor-1 (bi-1) (testis enhanced gene transcript). [swissprot;acc:p55061]	TEGT
2951	integrin beta-7 precursor. [swissprot;acc:p26010]	ITGB7
2952	serine/threonine-protein kinase receptor r3 precursor (ec 2.7.1.37) (skr3) (activin receptor-like kinase 1) (alk-1) (tgf-b superfamily receptor type i) (tsr-i). [swissprot;acc:p37023]	ACVRL1
2953	glioma pathogenesis-related protein (glipr) (rtvp-1 protein). [swissprot;acc:p48060]	GLIPR1
2954	nadh-ubiquinone oxidoreductase 39 kda subunit, mitochondrial precursor (ec 1.6.5.3) (ec 1.6.99.3) (complex i-39kd) (ci-39kd). [swissprot;acc:q16795]	NDUFA9
2955	fibrillin 2 precursor. [swissprot;acc:p35556]	FBN2
2956	protein transport protein sec24b (sec24-related protein b). [swissprot;acc:o95487]	SEC24B
2957	glutamyl aminopeptidase (ec 3.4.11.7) (eap) (aminopeptidase a) (apa) (differentiation antigen gp160). [swissprot;acc:q07075]	ENPEP

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.