MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Interaction Map	Value Type	Network Comparison Type	Filtered	green	red	network_comparison

Results: HTML CSV LaTeX

Showing element 101 to 150 of 8289 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Filtered  : 1

Rank	description	Interaction Map	green	red	network_comparison
51	junctophilin 2 (junctophilin type 2) (jp-2). [swissprot;acc:q9br39]	Low confidence	260.98	234.802	1.11149
	spermatogenesis associated 6. [refseq;acc:nm_019073]	High confidence	105	133	1.26667
52	amp deaminase 2 (ec 3.5.4.6) (amp deaminase isoform l). [swissprot;acc:q01433]
	sphingomyelin phosphodiesterase 2 (ec 3.1.4.12) (neutral sphingomyelinase) (nsmase) (n-smase) (lyso-platelet activating factor- phospholipase c) (lyso-paf-plc). [swissprot;acc:o60906]	Low confidence	260.98	234.802	1.11149
53	db83 protein. [swissprot;acc:p57088]
	transcription factor jun-b. [swissprot;acc:p17275]	High confidence	158.868	201.144	1.26611
54	cytoplasmic polyadenylation element binding protein 3. [refseq;acc:nm_014912]	Low confidence	240.822	267.448	1.11056
	transcription factor jun-d. [swissprot;acc:p17535]	High confidence	158.941	200.941	1.26425
55	cytoplasmic polyadenylation element binding protein 4. [refseq;acc:nm_030627]	Low confidence	240.78	267.376	1.11046
	protein kinase, interferon-inducible double stranded rna dependent activator; protein activator of the interferon-induced protein kinase. [refseq;acc:nm_003690]	High confidence	254.434	320.927	1.26134
56	brachyury protein (t protein). [swissprot;acc:o15178]	Low confidence	202.592	224.922	1.11022
	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-7 subunit. [swissprot;acc:o60262]	High confidence	336.233	266.856	1.25998
57	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-12 subunit. [swissprot;acc:q9ubi6]
	proto-oncogene protein c-fos (cellular oncogene fos) (g0/g1 switch regulatory protein 7). [swissprot;acc:p01100]	Low confidence	182.73	202.802	1.10985
58	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-4 subunit. [swissprot;acc:p50150]	High confidence	336.191	266.863	1.25979
	jun dimerization protein. [refseq;acc:nm_130469]	Low confidence	182.73	202.802	1.10985
59	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-3 subunit. [swissprot;acc:p29798]	High confidence	336.19	266.863	1.25978
	nadh-ubiquinone oxidoreductase subunit b17.2 (ec 1.6.5.3) (ec 1.6.99.3) (complex i-b17.2) (ci-b17.2) (cib17.2) (13 kda differentiation-associated protein). [swissprot;acc:q9ui09]	Low confidence	210.267	233.134	1.10875
60	fos-related antigen 2. [swissprot;acc:p15408]		182.961	202.793	1.10839
	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-8 subunit (gamma-9). [swissprot;acc:q9uk08]	High confidence	336.184	266.864	1.25976
61	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 subunit. [swissprot;acc:p30670]		336.182		1.25975
	protein fosb (g0/g1 switch regulatory protein 3). [swissprot;acc:p53539]	Low confidence	182.974	202.792	1.10831
62	fos-related antigen 1 (fra-1). [swissprot;acc:p15407]		183.017	202.79	1.10804
	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-10 subunit. [swissprot;acc:p50151]	High confidence	336.181	266.865	1.25974
63	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 like subunit. [swissprot;acc:q9y3k8]		336.178		1.25973
	putative rna-binding protein 7 (rna binding motif protein 7). [swissprot;acc:q9y580]	Low confidence	239.902	265.688	1.10749
64	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-11 subunit. [swissprot;acc:p50152]	High confidence	336.159	266.868	1.25965
	transcription factor jun-d. [swissprot;acc:p17535]	Low confidence	183.361	202.709	1.10552
65	guanine nucleotide-binding protein g(q), alpha subunit. [swissprot;acc:p50148]	High confidence	336.077	267.136	1.25807
	transcription factor jun-b. [swissprot;acc:p17275]	Low confidence	183.388	202.728	1.10546
66	guanine nucleotide-binding protein g(y), alpha subunit (alpha-11). [swissprot;acc:p29992]	High confidence	336.077	267.136	1.25807
	mitochondrial tumor suppressor gene 1; transcription factor mtsg1; at2 receptor-interacting protein 1; erythroid differentiation-related gene. [refseq;acc:nm_020749]	Low confidence	200.783	221.902	1.10518
67	guanine nucleotide-binding protein g(t), alpha-2 subunit (transducin alpha-2 chain). [swissprot;acc:p19087]	High confidence	336.075	267.14	1.25805
	retinoblastoma-associated factor 600. [refseq;acc:nm_020765]	Low confidence	149.799	165.535	1.10505
68	60s ribosomal protein l37a. [swissprot;acc:p12751]		217.005	239.692	1.10455
	guanine nucleotide-binding protein g(z), alpha subunit (g(x) alpha chain) (gz-alpha). [swissprot;acc:p19086]	High confidence	336.075	267.139	1.25805
69	guanine nucleotide-binding protein g(t), alpha-1 subunit (transducin alpha-1 chain). [swissprot;acc:p11488]			267.14
	testis-specific protein tex28. [swissprot;acc:o15482]	Low confidence	235.017	259.517	1.10425
70	27 kda golgi snare protein (golgi snap receptor complex member 2) (membrin). [swissprot;acc:o14653]
	guanine nucleotide-binding protein g(i), alpha-2 subunit (adenylate cyclase-inhibiting g alpha protein). [swissprot;acc:p04899]	High confidence	336.074	267.142	1.25804
71	cysteine-rich protein 1 (cysteine-rich intestinal protein) (crip) (cysteine-rich heart protein) (hcrhp). [swissprot;acc:p50238]	Low confidence	209.149	230.944	1.10421
	guanine nucleotide-binding protein g(i), alpha-1 subunit (adenylate cyclase-inhibiting g alpha protein). [swissprot;acc:p04898]	High confidence	336.073	267.144	1.25802
72	guanine nucleotide-binding protein g(k), alpha subunit (g(i) alpha-3). [swissprot;acc:p08754]
	set and mynd domain containing 2; hskm-b protein; zinc finger, mynd domain containing 14. [refseq;acc:nm_020197]	Low confidence	209.149	230.944	1.10421
73	junctophilin 3 (junctophilin type 3) (jp-3). [swissprot;acc:q8wxh2]	High confidence	362	288	1.25694
	set and mynd domain containing protein 1. [sptrembl;acc:q8nb12]	Low confidence	209.149	230.944	1.10421
74	junctophilin 2 (junctophilin type 2) (jp-2). [swissprot;acc:q9br39]	High confidence	362	288	1.25694
	putative adenosylhomocysteinase 2 (ec 3.3.1.1) (s-adenosyl-l- homocysteine hydrolase) (adohcyase). [swissprot;acc:o43865]	Low confidence	215.516	195.817	1.1006
75	nipsnap2 protein (glioblastoma amplified sequence). [swissprot;acc:o75323]		226.944	249.709	1.10031
	sphingomyelin phosphodiesterase 2 (ec 3.1.4.12) (neutral sphingomyelinase) (nsmase) (n-smase) (lyso-platelet activating factor- phospholipase c) (lyso-paf-plc). [swissprot;acc:o60906]	High confidence	362	288	1.25694

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.