Scientific

MK5 Microarray Data


Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

  • value_type as 'ranked' since this provides a very robust analysis method.
  • intercation map as 'high confidence'
  • network_comparison type as 'Divided' since this leads to a natural grouping of similar proteins
  • filtered as 'true' since this will only use the microarray measurements that have a sufficiently large confidence level.

  • Navigation/Query Panel:
    Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].
    Rank Gene Hugo description Value Type Network Comparison Type Interaction Map Filtered red green network_comparison
    Results: HTML CSV LaTeX Showing element 3068 to 3117 of 3228 in total
    Value Type	Ranked
    Network Comparison Type Divided
    Interaction Map High confidence
    Filtered 1
    red 0.00001
    green 0.00001
    network_comparison 1
    Rank Hugo description 3068 HECA headcase homolog; hhdc for homolog of drosophila headcase. [source:refseq;acc:nm_016217] 3069 BMP5 bone morphogenetic protein 5 precursor (bmp-5). [source:swissprot;acc:p22003] 3070 MDGA1 mam domain containing glycosylphosphatidylinositol anchor 1; glycosyl-phosphatidyl-inositol-mam. [source:refseq;acc:nm_153487] 3071 STK38 serine/threonine kinase 38; serine threonine protein kinase. [source:refseq;acc:nm_007271] 3072 PAK1IP1 pak1 interacting protein 1; pak1-interacting protein; pak/plc-interacting protein 1. [source:refseq;acc:nm_017906] 3073 RWDD1 rwd domain containing 1; ptd013 protein; cgi-24 protein. [source:refseq;acc:nm_015952] 3074 NT5DC3 tu12b1-ty protein. [source:refseq;acc:nm_016575] 3075 USP5 ubiquitin carboxyl-terminal hydrolase 5 (ec 3.1.2.15) (ubiquitin thiolesterase 5) (ubiquitin-specific processing protease 5) (deubiquitinating enzyme 5) (isopeptidase t). [source:swissprot;acc:p45974] 3076 placental protein 11 precursor (ec 3.4.21.-) (pp11). [source:swissprot;acc:p21128] 3077 H2AFJ h2a histone family, member j isoform 1. [source:refseq;acc:nm_018267] 3078 CREBL2 camp responsive element binding protein-like 2. [source:refseq;acc:nm_001310] 3079 CYP27B1 25-hydroxyvitamin d-1 alpha hydroxylase, mitochondrial precursor (ec 1.14.-.-) (25-ohd-1 alpha-hydroxylase) (25-hydroxyvitamin d3 1- alpha-hydroxylase) (vd3 1a hydroxylase) (p450c1 alpha) (p450vd1- alpha). [source:swissprot;acc:o15528] 3080 nucleosome assembly protein 1-like 4 (nucleosome assembly protein 2) (nap2). [source:swissprot;acc:q99733] 3081 PTPMT1 nadh-ubiquinone oxidoreductase 30 kda subunit, mitochondrial precursor (ec 1.6.5.3) (ec 1.6.99.3) (complex i-30kd) (ci-30kd). [source:swissprot;acc:o75489] 3082 CRYAB alpha crystallin b chain (alpha(b)-crystallin) (rosenthal fiber component). [source:swissprot;acc:p02511] 3083 GLRB glycine receptor beta chain precursor (glycine receptor 58 kda subunit). [source:swissprot;acc:p48167] 3084 MAP2K1IP1 mitogen-activated protein kinase kinase 1 interacting protein 1 (mek binding partner 1) (mp1) (pro2783). [source:swissprot;acc:q9uha4] 3085 UGT2B10 udp-glucuronosyltransferase 2b10 precursor, microsomal (ec 2.4.1.17) (udpgt). [source:swissprot;acc:p36537] 3086 udp-glucuronosyltransferase 2b15 precursor, microsomal (ec 2.4.1.17) (udpgt) (udpgth-3) (hlug4). [source:swissprot;acc:p54855] 3087 ALDOC fructose-bisphosphate aldolase c (ec 4.1.2.13) (brain-type aldolase). [source:swissprot;acc:p09972] 3088 YWHAE 14-3-3 protein epsilon (mitochondrial import stimulation factor l subunit) (protein kinase c inhibitor protein-1) (kcip-1) (14-3-3e). [source:swissprot;acc:p42655] 3089 PRKAR1A camp-dependent protein kinase type i-alpha regulatory chain (tissue- specific extinguisher-1) (tse1). [source:swissprot;acc:p10644] 3090 EZH1 enhancer of zeste homolog 1 (enx-2). [source:swissprot;acc:q92800] 3091 MLX transcription factor-like protein 4 (max-like bhlhzip protein) (bigmax protein) (mlx). [source:swissprot;acc:q9uh92] 3092 DRG2 developmentally regulated gtp-binding protein 2 (drg 2). [source:swissprot;acc:p55039] 3093 ptd016 protein. [source:refseq;acc:nm_016125] 3094 UBE2S ubiquitin-conjugating enzyme e2-24 kda (ec 6.3.2.19) (ubiquitin- protein ligase) (ubiquitin carrier protein) (e2-epf5). [source:swissprot;acc:q16763] 3095 C10orf137 erythroid differentiation-related factor 1. [source:refseq;acc:nm_015608] 3096 NPM3 nucleoplasmin 3. [source:swissprot;acc:o75607] 3097 SEC23IP sec23-interacting protein p125; phospholipase. [source:refseq;acc:nm_007190] 3098 EZH2 enhancer of zeste homolog 2 (enx-1). [source:swissprot;acc:q15910] 3099 CAV1 caveolin-1. [source:swissprot;acc:q03135] 3100 presenilin enhancer 2; hematopoietic stem/progenitor cells protein mds033. [source:refseq;acc:nm_172341] 3101 gamma-interferon inducible lysosomal thiol reductase precursor (gamma-interferon-inducible protein ip-30). [source:swissprot;acc:p13284] 3102 C19orf56 protein cgi-140 (protein ptd008) (my006 protein). [source:swissprot;acc:q9y284] 3103 LIG1 dna ligase i (ec 6.5.1.1) (polydeoxyribonucleotide synthase [atp]). [source:swissprot;acc:p18858] 3104 SNORD23 glioma tumor suppressor candidate region gene 2 protein (p60). [source:swissprot;acc:q9nzm5] 3105 TGFB1 transforming growth factor beta 1 precursor (tgf-beta 1). [source:swissprot;acc:p01137] 3106 PTOV1 prostate tumor overexpressed gene 1; prostate tumor over expressed gene 1. [source:refseq;acc:nm_017432] 3107 LYL1 lyl-1 protein (lymphoblastic leukemia derived sequence 1). [source:swissprot;acc:p12980] 3108 SNX16 sorting nexin 16. [source:swissprot;acc:p57768] 3109 WISP1 wnt1 inducible signaling pathway protein 1 isoform 1 precursor; wnt-1 signaling pathway protein 1; wnt1 signaling pathway protein 1; wnt-1 inducible signaling pathway protein 1. [source:refseq;acc:nm_003882] 3110 RAB2A ras-related protein rab-2a. [source:swissprot;acc:p08886] 3111 STK3 serine/threonine protein kinase 3 (ec 2.7.1.37) (ste20-like kinase mst2) (mst-2) (mammalian ste20-like protein kinase 2) (serine/threonine protein kinase krs-1). [source:swissprot;acc:q13188] 3112 RAB11A ras-related protein rab-11a (rab-11) (24kg) (yl8). [source:swissprot;acc:p24410] 3113 NUTF2 nuclear transport factor 2 (ntf-2) (placental protein 15) (pp15). [source:swissprot;acc:p13662] 3114 TSC22D1 regulatory protein tsc-22 (tgfb stimulated clone 22 homolog). [source:swissprot;acc:q15714] 3115 STK24 serine/threonine protein kinase 24 (ec 2.7.1.37) (ste20-like kinase mst3) (mst-3) (mammalian ste20-like protein kinase 3). [source:swissprot;acc:q9y6e0] 3116 CAB39L mo25-like protein. [source:swissprot;acc:q9h9s4] 3117 FNDC3A ba203i16.1 (hypothetical protein kiaa0970). [source:sptrembl;acc:q9h1w1] Legend: - Rank is the rank after comparing the two networks - Hugo is the HGNC identifier if it exists - Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions. - Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them - Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions. - Filtered specifies whether we only included the high confidence microarry measurements or not.

    - http://analysis.yellowcouch.org/