MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	Network Comparison Type	description	Value Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1258 to 1307 of 33156 in total

Network Comparison Type  : Divided
Filtered  : 1

Rank	Hugo	description	Value Type	Interaction Map	red	green	network_comparison
158	DNAJC8	dnaj homolog subfamily c member 8 (splicing protein spf31) (hspc315). [swissprot;acc:o75937]	Ranked	Low confidence	219.838	207.417	1.05988
	GPSM2	mosaic protein lgn. [swissprot;acc:p81274]		High confidence	249.663	298.263	1.19466
	MAGEA6	melanoma-associated antigen 6 (mage-6 antigen) (mage3b). [swissprot;acc:p43360]	Measured		23693.7	18263	1.29736
	MTUS1	mitochondrial tumor suppressor gene 1; transcription factor mtsg1; at2 receptor-interacting protein 1; erythroid differentiation-related gene. [refseq;acc:nm_020749]		Low confidence	6434.71	6976.28	1.08416
	SEPT7	septin 7 (cdc10 protein homolog). [swissprot;acc:q16181]	Squared	High confidence	89182.8	125229	1.40418
	STRN	striatin. [swissprot;acc:o43815]	Rooted	Low confidence	66.4354	70.987	1.06851
	WDR33	wd-repeat protein wdc146. [swissprot;acc:q9c0j8]	Squared		57732.3	51372.1	1.12381
159	no value	rna-binding protein. [refseq;acc:nm_019027]	Rooted	High confidence	52.7642	61.9019	1.17318
		transgelin 2 (sm22-alpha homolog). [swissprot;acc:p37802]		Low confidence	65.5823	70.0536	1.06818
	BRP44	brain protein 44. [swissprot;acc:o95563]	Measured		10392.1	11259.7	1.08349
	GGNBP2	c3hc4-type zinc finger protein; likely ortholog of mouse dioxin inducible factor 3. [refseq;acc:nm_024835]	Ranked		219.838	207.417	1.05988
	HINT1	histidine triad nucleotide-binding protein 1 (adenosine 5'- monophosphoramidase) (protein kinase c inhibitor 1) (protein kinase c- interacting protein 1) (pkci-1). [swissprot;acc:p49773]	Squared		22187.9	19810.5	1.12001
	NDN	necdin. [swissprot;acc:q99608]	Measured	High confidence	23693.7	18263	1.29736
	RGS17	regulator of g-protein signaling 17 (rgs17). [swissprot;acc:q9ugc6]	Ranked		249.663	298.263	1.19466
	SEPT6	septin 6. [swissprot;acc:q14141]	Squared		88953.6	124854	1.40359
160	no value	apobec-1 complementation factor isoform 1; apobec-1 stimulating protein; apo-b rna editing protein. [refseq;acc:nm_014576]	Rooted		52.7642	61.9019	1.17318
		homeobox protein hox-c4 (hox-3e) (cp19). [swissprot;acc:p09017]	Squared		173408	242989	1.40126
	APC	adenomatous polyposis coli protein (apc protein). [swissprot;acc:p25054]	Ranked	Low confidence	222.31	235.538	1.0595
	DCHS1	protocadherin 16 precursor (cadherin 19) (cadherin fibroblast 1). [swissprot;acc:q96jq0]	Rooted		65.7817	70.2555	1.06801
	GNAO1	guanine nucleotide-binding protein g(o), alpha subunit 1. [swissprot;acc:p09471]	Ranked	High confidence	249.663	298.263	1.19466
	MAGED1	melanoma-associated antigen d1 (mage-d1 antigen) (neurotrophin receptor-interacting mage homolog) (pro2292). [swissprot;acc:q9y5v3]	Measured		23693.7	18263	1.29736
	MTHFR	methylenetetrahydrofolate reductase (ec 1.5.1.20). [swissprot;acc:p42898]		Low confidence	10452.8	11320.8	1.08304
	PCSK5	proprotein convertase subtilisin/kexin type 5 precursor (ec 3.4.21.-) (proprotein convertase pc5) (subtilisin/kexin-like protease pc5) (convertase pc5) (pc6) (hpc6). [swissprot;acc:q92824]	Squared		54208.6	48413.8	1.11969
161	APC2	adenomatous polyposis coli like. [refseq;acc:nm_005883]	Ranked		222.34	235.547	1.0594
	HOXB4	homeobox protein hox-b4 (hox-2f) (hox-2.6). [swissprot;acc:p17483]	Squared	High confidence	173408	242989	1.40126
	MAGEF1	melanoma-associated antigen f1 (mage-f1 antigen). [swissprot;acc:q9hay2]	Measured		23693.7	18263	1.29736
	PBLD	mawd binding protein (unknown protein 32 from 2d-page of liver tissue). [swissprot;acc:p30039]	Squared	Low confidence	60522.9	67721	1.11893
	RAP1GAP	rap1 gtpase-activating protein 1 (rap1gap). [swissprot;acc:p47736]	Ranked	High confidence	249.663	298.263	1.19466
	SLC15A2	oligopeptide transporter, kidney isoform (peptide transporter 2) (kidney h+/peptide cotransporter) (solute carrier family 15, member 2). [swissprot;acc:q16348]	Rooted	Low confidence	70.5717	75.371	1.06801
	SLC16A5	monocarboxylate transporter 6 (mct 6) (mct 5). [swissprot;acc:o15375]	Measured		10351.8	11210.8	1.08298
	SYNCRIP	ns1-associated protein 1. [refseq;acc:nm_006372]	Rooted	High confidence	52.7642	61.9019	1.17318
162	DAD1	defender against cell death 1 (dad-1). [swissprot;acc:p46966]	Ranked	Low confidence	197.99	186.913	1.05926
	GABARAP	gaba(a) receptor-associated protein; gaba(a)-receptor-associated protein. [refseq;acc:nm_007278]	Squared		53479.8	47812.1	1.11854
	HNRNPR	heterogeneous nuclear ribonucleoprotein r (hnrnp r). [swissprot;acc:o43390]	Rooted	High confidence	52.7642	61.9019	1.17318
	HOXC5	homeobox protein hox-c5 (hox-3d) (cp11). [swissprot;acc:q00444]	Squared		173408	242989	1.40126
	MAGEB6B	melanoma antigen, family b, 6. [refseq;acc:nm_173523]	Measured		23693.7	18263	1.29736
	NOSTRIN	nostrin. [refseq;acc:nm_052946]	Ranked		209.299	249.187	1.19058
	PSCD1	cytohesin 1 (sec7 homolog b2-1). [swissprot;acc:q15438]	Measured	Low confidence	12424.3	11472.3	1.08298
	SEPT8	septin-like protein kiaa0202 (fragment). [swissprot;acc:q92599]	Rooted		98.7481	105.459	1.06796
163	no value	homeobox protein hox-c6 (hox-3c) (hho.c8) (cp25). [swissprot;acc:p09630]	Squared	High confidence	173408	242989	1.40126
		melanoma-associated antigen 4 (mage-4 antigen) (mage-x2) (mage-41). [swissprot;acc:p43358]	Measured		23693.7	18263	1.29736
	CPSF1	cleavage and polyadenylation specificity factor, 160 kda subunit (cpsf 160 kda subunit). [swissprot;acc:q10570]	Squared	Low confidence	56828	50808.5	1.11847
	EIF4G1	eukaryotic translation initiation factor 4 gamma (eif-4-gamma) (eif- 4g) (eif4g) (p220). [swissprot;acc:q04637]	Rooted	High confidence	52.7702	61.8915	1.17285
	SLC16A1	monocarboxylate transporter 1 (mct 1). [swissprot;acc:p53985]	Measured	Low confidence	10348.5	11206.7	1.08293
	SNF8	eap30 subunit of ell complex. [refseq;acc:nm_007241]	Ranked	High confidence	209.299	249.187	1.19058
	STRN4	striatin 4 (zinedin). [swissprot;acc:q9nrl3]	Rooted	Low confidence	66.5155	71.0097	1.06757
	VPS41	vacuolar assembly protein vps41 homolog (s53). [swissprot;acc:p49754]	Ranked		202.698	191.393	1.05907
164	BACH1	transcription regulator protein bach1 (btb and cnc homolog 1) (ha2303). [swissprot;acc:o14867]	Squared		37094.3	41487.9	1.11844
	HOXD4	homeobox protein hox-d4 (hox-4b) (hox-5.1) (hho.c13). [swissprot;acc:p09016]		High confidence	173408	242989	1.40126
	MAGEA9	melanoma-associated antigen 9 (mage-9 antigen). [swissprot;acc:p43362]	Measured		23693.7	18263	1.29736

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.