MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Value Type	Gene	description	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1214 to 1263 of 12912 in total

Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

Rank	Value Type	description	red	green	network_comparison
304	Ranked	40s ribosomal protein s15 (rig protein). [swissprot;acc:p11174]	242.339	266.986	1.1017
	Squared	proto-oncogene tyrosine-protein kinase abl1 (ec 2.7.1.112) (p150) (c-abl). [swissprot;acc:p00519]	28896.2	36767	1.27238
	Rooted	cytohesin 4. [swissprot;acc:q9uia0]	203.673	182.638	1.11517
305	Measured	odd-skipped related 1; odz (odd oz/ten-m) related 1. [refseq;acc:nm_145260]	3856.29	4624.15	1.19912
	Ranked	mitochondrial ribosomal protein l2. [refseq;acc:nm_015950]	242.339	266.986	1.1017
	Squared	proto-oncogene tyrosine-protein kinase fyn (ec 2.7.1.112) (p59-fyn) (syn) (slk). [swissprot;acc:p06241]	28896.2	36767	1.27238
	Rooted	cytohesin 3 (arf nucleotide-binding site opener 3) (arno3 protein) (general receptor of phosphoinositides 1) (grp1). [swissprot;acc:o43739]	203.673	182.638	1.11517
306	Measured	pnas-18. [sptrembl;acc:q9bzu3]	13680.5	11409.6	1.19903
	Ranked	60s ribosomal protein l14 (cag-isl 7). [swissprot;acc:p50914]	242.153	266.673	1.10126
	Squared	proto-oncogene tyrosine-protein kinase fgr (ec 2.7.1.112) (p55-fgr) (c-fgr). [swissprot;acc:p09769]	28896.2	36767	1.27238
	Rooted	rna-binding region containing protein 2 (hepatocellular carcinoma protein 1) (splicing factor hcc1). [swissprot;acc:q14498]	56.3935	62.8817	1.11505
307	Measured	t-complex protein 1, gamma subunit (tcp-1-gamma) (cct-gamma). [swissprot;acc:p49368]	12365.2	14824.9	1.19892
	Ranked	serine racemase (ec 5.1.1.-). [swissprot;acc:q9gzt4]	242.153	266.673	1.10126
	Squared	grb2-related adaptor protein 2 (gads protein) (growth factor receptor binding protein) (grblg) (grf40 adaptor protein) (grf-40) (grb-2-like protein) (grb2l) (grbx) (p38) (hematopoietic cell-associated adaptor protein grpl) (adapter protein grid) (sh3-sh2-sh3 adaptor mona). [swissprot;acc:o75791]	28896.4	36766.8	1.27237
	Rooted	transcriptional co-repressor sin3a; transcriptional regulator, sin3a (yeast). [refseq;acc:nm_015477]	50.4687	45.2733	1.11476
308	Measured	segment polarity protein dishevelled homolog dvl-1 (dishevelled-1) (dsh homolog 1). [swissprot;acc:o14640]	4977.09	5966.44	1.19878
	Ranked	60s ribosomal protein l34. [swissprot;acc:p49207]	242.153	266.673	1.10126
	Squared	1-acyl-sn-glycerol-3-phosphate acyltransferase gamma (ec 2.3.1.51) (1- agp acyltransferase 3) (1-agpat 3) (lysophosphatidic acid acyltransferase-gamma) (lpaat-gamma) (1-acylglycerol-3-phosphate o- acyltransferase 3). [swissprot;acc:q9nrz7]	30596.2	38919.9	1.27205
	Rooted	density-regulated protein (drp) (drp1 protein) (smooth muscle cell associated protein-3) (smap-3). [swissprot;acc:o43583]	50.4687	45.2733	1.11476
309	Measured	segment polarity protein dishevelled homolog dvl-2 (dishevelled-2) (dsh homolog 2). [swissprot;acc:o14641]	4977.8	5966.14	1.19855
	Ranked	protein transport protein sec61 alpha subunit isoform 2 (sec61 alpha- 2). [swissprot;acc:q9y2r3]	242.153	266.673	1.10126
	Squared	ccaat displacement protein (cdp) (cut-like 1). [swissprot;acc:p39880]	28900.8	36762.6	1.27203
	Rooted	u6 snrna-associated sm-like protein lsm2 (small nuclear ribonuclear protein d homolog) (g7b) (snrnp core sm-like protein sm-x5). [swissprot;acc:q9y333]	56.185	62.6036	1.11424
310	Measured	squamous cell carcinoma antigen recognized by t cells 1; u4/u6.u5 tri-snrnp-associated 110 kda protein; ige autoantigen; sart1(259) protein; sart1(800) protein. [refseq;acc:nm_005146]	4909.79	5878.79	1.19736
	Ranked	protein transport protein sec61 alpha subunit isoform 1 (sec61 alpha- 1). [swissprot;acc:p38378]	242.153	266.673	1.10126
	Squared	homeobox protein cux-2 (cut-like 2) (fragment). [swissprot;acc:o14529]	28901.4	36762.1	1.27198
	Rooted	myosin heavy chain, cardiac muscle alpha isoform (myhc-alpha). [swissprot;acc:p13533]	95.0526	85.3206	1.11406
311	Measured	segment polarity protein dishevelled homolog dvl-3 (dishevelled-3) (dsh homolog 3). [swissprot;acc:q92997]	4981.52	5964.58	1.19734
	Ranked	protein translation factor sui1 homolog gc20. [swissprot;acc:o60739]	242.627	267.151	1.10108
	Squared	1-acyl-sn-glycerol-3-phosphate acyltransferase delta (ec 2.3.1.51) (1- agp acyltransferase 4) (1-agpat 4) (lysophosphatidic acid acyltransferase-delta) (lpaat-delta) (1-acylglycerol-3-phosphate o- acyltransferase 4). [swissprot;acc:q9nrz5]	30566.4	38866.5	1.27154
	Rooted	myosin heavy chain, skeletal muscle, fetal (myosin heavy chain iib) (myhc-iib). [swissprot;acc:q9y623]	95.0526	85.3206	1.11406
312	Measured	u6 snrna-associated sm-like protein lsm7. [swissprot;acc:q9uk45]	4598.21	5500.48	1.19622
	Ranked	60s ribosomal protein l3-like. [swissprot;acc:q92901]	242.195	266.663	1.10103
	Squared	methyltransferase like 2. [refseq;acc:nm_018396]	71576.8	56326.7	1.27074
	Rooted	myosin heavy chain, skeletal muscle, perinatal (myhc-perinatal). [swissprot;acc:p13535]	95.0526	85.3206	1.11406
313	Measured	protein phosphatase inhibitor 2 (ipp-2). [swissprot;acc:p41236]	21644.2	18098.7	1.1959
	Ranked	ribonucleotide reductase m2 b (tp53 inducible); p53-inducible ribonucleotide reductase small subunit 2 homolog. [refseq;acc:nm_015713]	232.473	211.207	1.10069
	Squared	cytoplasmic dynein light chain (t-complex testis-specific protein 1 homolog) (protein cw-1). [swissprot;acc:q15763]	71576.8	56326.7	1.27074
	Rooted	myosin heavy chain, skeletal muscle, adult 2 (myosin heavy chain iia) (myhc-iia). [swissprot;acc:q9ukx2]	95.0526	85.3206	1.11406
314	Measured	type 1 protein phosphatase inhibitor. [refseq;acc:nm_025210]	21632.5	18090	1.19583
	Ranked	methionine aminopeptidase 1 (ec 3.4.11.18) (metap 1) (map 1) (peptidase m 1). [swissprot;acc:p53582]	244.126	268.604	1.10027
	Squared	fzr1 protein; fizzy-related protein; cdc20-like 1b. [refseq;acc:nm_016263]	71576.8	56326.7	1.27074
	Rooted	myosin heavy chain, fast skeletal muscle, embryonic (muscle embryonic myosin heavy chain) (smhce). [swissprot;acc:p11055]	95.0526	85.3206	1.11406
315	Measured	ribosome biogenesis regulatory protein homolog. [swissprot;acc:q15050]	21370.8	17896.5	1.19413
	Ranked	methionine aminopeptidase 2 (ec 3.4.11.18) (metap 2) (peptidase m 2) (initiation factor 2 associated 67 kda glycoprotein) (p67) (p67eif2). [swissprot;acc:p50579]	244.126	268.604	1.10027
	Squared	proprotein convertase subtilisin/kexin type 5 precursor (ec 3.4.21.-) (proprotein convertase pc5) (subtilisin/kexin-like protease pc5) (convertase pc5) (pc6) (hpc6). [swissprot;acc:q92824]	71576.8	56326.7	1.27074
	Rooted	myosin heavy chain, skeletal muscle, adult 1 (myosin heavy chain iix/d) (myhc-iix/d). [swissprot;acc:p12882]	95.0526	85.3206	1.11406
316	Measured	serine/threonine protein phosphatase pp1-alpha 1 catalytic subunit (ec 3.1.3.16) (pp-1a). [swissprot;acc:p08129]	21370.8	17896.5	1.19413
	Ranked	protein translation factor sui1 homolog (sui1iso1). [swissprot;acc:p41567]	242.694	267.017	1.10022
	Squared	neural wiskott-aldrich syndrome protein (n-wasp). [swissprot;acc:o00401]	28918.3	36746	1.27068

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.