MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Rank	Gene	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 551 to 600 of 8289 in total

Value Type  : Measured
Network Comparison Type  : Divided
Filtered  : 1

Rank	description	Interaction Map	red	green	network_comparison
276	putative rna-binding protein 15 (rna binding motif protein 15) (one-twenty two protein). [swissprot;acc:q96t37]	High confidence	3119.98	2579.49	1.20953
	u2 small nuclear ribonucleoprotein a' (u2 snrnp-a'). [swissprot;acc:p09661]	Low confidence	7762.71	8229.36	1.06011
277	dual oxidase 2 precursor; dual oxidase-like domains 2; nicotinamide adenine dinucleotide phosphate oxidase; flavoprotein nadph oxidase; nadph thyroid oxidase 2; nadh/nadph thyroid oxidase p138-tox; nadph oxidase/peroxidase duox2. [refseq;acc:nm_014080]		7900.15	8374.91	1.0601
	regulator of g-protein signaling 20 (rgs20) (regulator of gz- selective protein signaling 1) (gz-selective gtpase-activating protein) (g(z)gap). [swissprot;acc:o76081]	High confidence	3119.98	2579.49	1.20953
278	ba395l14.12 (novel protein similar to small nuclear ribonucleoprotein polypeptide a' (snrpa1)). [sptrembl;acc:q9nu36]	Low confidence	7762.96	8229.42	1.06009
	transcription factor lbx1. [swissprot;acc:p52954]	High confidence	3119.98	2579.49	1.20953
279	dual oxidase 1 precursor; nadph thyroid oxidase 1; flavoprotein nadph oxidase; nicotinamide adenine dinucleotide phosphate oxidase. [refseq;acc:nm_017434]	Low confidence	7900.92	8375.39	1.06005
	mosaic protein lgn. [swissprot;acc:p81274]	High confidence	3119.98	2579.49	1.20953
280	diacylglycerol o-acyltransferase 1 (ec 2.3.1.20) (diglyceride acyltransferase) (acat related gene product 1). [swissprot;acc:o75907]	Low confidence	7902.9	8376.6	1.05994
	regulator of g-protein signaling 17 (rgs17). [swissprot;acc:q9ugc6]	High confidence	3119.98	2579.49	1.20953
281	cytochrome b-245 heavy chain (p22 phagocyte b-cytochrome) (neutrophil cytochrome b, 91 kda polypeptide) (cgd91-phox) (gp91-phox) (heme binding membrane glycoprotein gp91phox) (cytochrome b(558) beta chain) (superoxide-generating nadph oxidase heavy chain subunit). [swissprot;acc:p04839]	Low confidence	7904.19	8377.38	1.05987
	guanine nucleotide-binding protein g(o), alpha subunit 1. [swissprot;acc:p09471]	High confidence	3119.98	2579.49	1.20953
282	nadph oxidase, ef hand calcium-binding domain 5. [refseq;acc:nm_024505]	Low confidence	7904.14	8377.35	1.05987
	rap1 gtpase-activating protein 1 (rap1gap). [swissprot;acc:p47736]	High confidence	3119.98	2579.49	1.20953
283	nadph oxidase 4. [refseq;acc:nm_016931]	Low confidence	7904.2	8377.39	1.05987
	polymerase (dna directed) iota; rad30 (s. cerevisiae) homolog b; polymerase (dna-directed), iota. [refseq;acc:nm_007195]	High confidence	5221.28	6314.35	1.20935
284	nadph oxidase 3; nadph oxidase catalytic subunit-like 3. [refseq;acc:nm_015718]	Low confidence	7904.17	8377.37	1.05987
	paxillin. [swissprot;acc:p49023]	High confidence	5221.28	6314.35	1.20935
285	nadph oxidase homolog 1 (nox-1) (noh-1) (nadh/nadph mitogenic oxidase subunit p65-mox) (mitogenic oxidase 1) (mox1). [swissprot;acc:q9y5s8]	Low confidence	7904.2	8377.39	1.05987
	poly(a) polymerase alpha (ec 2.7.7.19) (pap) (polynucleotide adenylyltransferase alpha) (fragment). [swissprot;acc:p51003]	High confidence	23326.5	19296.4	1.20885
286	exocyst complex component sec5. [swissprot;acc:q96kp1]		23316	19288.8	1.20878
	sedlin. [swissprot;acc:o14582]	Low confidence	9059.8	9601.05	1.05974
287	adiponectin receptor 2. [refseq;acc:nm_024551]		7170.39	7598.55	1.05971
	poly(a) polymerase gamma (ec 2.7.7.19) (pap gamma) (polynucleotide adenylyltransferase gamma) (srp rna 3' adenylating enzyme). [swissprot;acc:q9bwt3]	High confidence	23303.1	19279.5	1.2087
288	blocked early in transport 1 homolog (s. cerevisiae) like; golgi snare 15 kda protein. [refseq;acc:nm_016526]	Low confidence	8155.32	8641.69	1.05964
	cleavage and polyadenylation specificity factor, 73 kda subunit (cpsf 73 kda subunit). [swissprot;acc:q9ukf6]	High confidence	23422.4	19380.3	1.20857
289	splicing factor 3b subunit 1 (spliceosome associated protein 155) (sap 155) (sf3b155) (pre-mrna splicing factor sf3b 155 kda subunit). [swissprot;acc:o75533]	Low confidence	7752.95	8214.32	1.05951
	u6 snrna-associated sm-like protein lsm6 (sm protein f). [swissprot;acc:q9y4y8]	High confidence	4682.88	5646.19	1.20571
290	transcription factor e2f1 (e2f-1) (retinoblastoma binding protein 3) (rbbp-3) (prb-binding protein e2f-1) (pbr3) (retinoblastoma-associated protein 1) (rbap-1). [swissprot;acc:q01094]	Low confidence	6885.52	7293.37	1.05923
	tuftelin-interacting protein 11 (hspc006). [swissprot;acc:q9ubb9]	High confidence	4991.48	6014.08	1.20487
291	putative glialblastoma cell differentiation-related; putative glialblastoma cell differentiation-related protein. [refseq;acc:nm_016172]		44490.5	36927.5	1.20481
	transcription factor e2f2 (e2f-2). [swissprot;acc:q14209]	Low confidence	6885.52	7293.37	1.05923
292	60s ribosomal protein l27. [swissprot;acc:p08526]		7860.4	8325.71	1.0592
	nucleotide-binding protein 1 (nbp 1). [swissprot;acc:p53384]	High confidence	4641.09	5588.75	1.20419
293	nucleotide binding protein 2 (nbp 2). [swissprot;acc:q9y5y2]
	splicing factor 3b subunit 2 (spliceosome associated protein 145) (sap 145) (sf3b150) (pre-mrna splicing factor sf3b 145 kda subunit). [swissprot;acc:q13435]	Low confidence	7675.19	8129.16	1.05915
294	cleavage stimulation factor subunit 3; cleavage stimulation factor, 3' pre-rna, subunit 3, 77kd. [refseq;acc:nm_001326]	High confidence	22515.5	18702.6	1.20387
	ubiquitin-conjugating enzyme e2 g1 (ec 6.3.2.19) (ubiquitin-protein ligase g1) (ubiquitin carrier protein g1) (e217k) (ubc7). [swissprot;acc:q99462]	Low confidence	7590.39	8039.23	1.05913
295	5-methyltetrahydrofolate--homocysteine methyltransferase (ec 2.1.1.13) (methionine synthase, vitamin-b12 dependent) (ms). [swissprot;acc:q99707]		9113.16	9650.42	1.05895
	ral guanine nucleotide dissociation stimulator-like 1 (ralgds-like 1). [swissprot;acc:q9nzl6]	High confidence	13261.9	11017.8	1.20368
296	splicing factor 3a subunit 2 (spliceosome associated protein 62) (sap 62) (sf3a66). [swissprot;acc:q15428]		4911.81	5909.18	1.20306
	tissue alpha-l-fucosidase precursor (ec 3.2.1.51) (alpha-l-fucosidase i) (alpha-l-fucoside fucohydrolase). [swissprot;acc:p04066]	Low confidence	8417.28	8911.22	1.05868
297	fucosidase, alpha-l- 2, plasma. [refseq;acc:nm_032020]		8414.05	8907.06	1.05859
	krueppel-like factor 5 (intestinal-enriched krueppel-like factor) (colon krueppel-like factor) (transcription factor bteb2) (basic transcription element binding protein 2) (bte-binding protein 2) (gc box binding protein 2). [swissprot;acc:q13887]	High confidence	4911.81	5909.18	1.20306
298	fzr1 protein; fizzy-related protein; cdc20-like 1b. [refseq;acc:nm_016263]	Low confidence	8708.47	9218.39	1.05855
	u6 snrna-associated sm-like protein lsm2 (small nuclear ribonuclear protein d homolog) (g7b) (snrnp core sm-like protein sm-x5). [swissprot;acc:q9y333]	High confidence	4633.92	5572.85	1.20262
299	anillin, actin binding protein (scraps homolog, drosophila); anillin (drosophila scraps homolog), actin binding protein. [refseq;acc:nm_018685]	Low confidence	8904.93	9426.29	1.05855
	ba395l14.12 (novel protein similar to small nuclear ribonucleoprotein polypeptide a' (snrpa1)). [sptrembl;acc:q9nu36]	High confidence	4914.27	5907.12	1.20203
300	nitrogen fixation cluster-like. [refseq;acc:nm_014301]	Low confidence	8667.67	9173.88	1.0584
	u2 small nuclear ribonucleoprotein a' (u2 snrnp-a'). [swissprot;acc:p09661]	High confidence	4914.27	5907.12	1.20203

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.