MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Value Type	Network Comparison Type	Filtered	Interaction Map	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1575 to 1624 of 8289 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Filtered  : 1

Rank	description	Interaction Map	red	green	network_comparison
788	eukaryotic translation initiation factor 4 gamma, 3. [refseq;acc:nm_003760]	Low confidence	200.788	195.605	1.0265
	hira-interacting protein 5 (cgi-33). [swissprot;acc:q9ums0]	High confidence	138.705	132.538	1.04653
789	40s ribosomal protein sa (p40) (34/67 kda laminin receptor) (colon carcinoma laminin-binding protein) (nem/1chd4) (multidrug resistance- associated protein mgr1-ag). [swissprot;acc:p08865]		224.244	234.511	1.04578
	polypeptide n-acetylgalactosaminyltransferase 2; udp-galnac transferase 2. [refseq;acc:nm_004481]	Low confidence	205.859	200.547	1.02649
790	40s ribosomal protein s21. [swissprot;acc:p35265]	High confidence	224.244	234.511	1.04578
	eukaryotic translation initiation factor 4 gamma (eif-4-gamma) (eif- 4g) (eif4g) (p220). [swissprot;acc:q04637]	Low confidence	200.79	195.608	1.02649
791	cytoplasmic antiproteinase 3 (cap3) (cap-3) (protease inhibitor 9) (serpin b9). [swissprot;acc:p50453]	High confidence	224.244	234.511	1.04578
	similar to expressed sequence ai415388 (fragment). [sptrembl;acc:q8n428]	Low confidence	205.859	200.547	1.02649
792	hiv-1 rev binding protein 2; rev interacting protein. [refseq;acc:nm_007043]		204.204	198.939	1.02647
	maspin precursor (protease inhibitor 5). [swissprot;acc:p36952]	High confidence	224.244	234.511	1.04578
793	bomapin (protease inhibitor 10) (serpin b10). [swissprot;acc:p48595]
	similar to atp/gtp-binding protein. [sptrembl;acc:q8nem8]	Low confidence	184.195	179.447	1.02646
794	plasminogen activator inhibitor-2 precursor (pai-2) (placental plasminogen activator inhibitor) (monocyte arg-serpin) (urokinase inhibitor). [swissprot;acc:p05120]	High confidence	224.244	234.511	1.04578
	trna (5-methylaminomethyl-2-thiouridylate)-methyltransferase (ec 2.1.1.61). [swissprot;acc:o75648]	Low confidence	184.195	179.447	1.02646
795	calcium-dependent protease, small subunit (calpain regulatory subunit) (calcium-activated neutral proteinase) (canp). [swissprot;acc:p04632]		202.525	197.308	1.02644
	serpin b11. [swissprot;acc:q96p15]	High confidence	224.244	234.511	1.04578
796	grancalcin. [swissprot;acc:p28676]	Low confidence	202.524	197.308	1.02644
	placental thrombin inhibitor (cytoplasmic antiproteinase) (cap) (protease inhibitor 6) (pi-6). [swissprot;acc:p35237]	High confidence	224.244	234.511	1.04578
797	asc-1 complex subunit p100. [refseq;acc:nm_032204]	Low confidence	211.636	206.184	1.02644
	cytoplasmic antiproteinase 2 (cap2) (cap-2) (protease inhibitor 8) (serpin b8). [swissprot;acc:p50452]	High confidence	224.244	234.511	1.04578
798	leukocyte elastase inhibitor (lei) (monocyte/neutrophil elastase inhibitor) (m/nei) (ei). [swissprot;acc:p30740]
	sorcin (22 kda protein) (cp-22) (v19). [swissprot;acc:p30626]	Low confidence	202.524	197.308	1.02644
799	amp deaminase 2 (ec 3.5.4.6) (amp deaminase isoform l). [swissprot;acc:q01433]		201.294	196.11	1.02643
	sequestosome 1; ubiquitin-binding protein p62; phosphotyrosine independent ligand for the lck sh2 domain p62. [refseq;acc:nm_003900]	High confidence	221.965	212.404	1.04501
800	nonspecific lipid-transfer protein, mitochondrial precursor (nsl-tp) (sterol carrier protein 2) (scp-2) (sterol carrier protein x) (scp-x) (scpx). [swissprot;acc:p22307]
	rp42 homolog; squamous cell carcinoma-related oncogene. [refseq;acc:nm_020640]	Low confidence	202.755	197.536	1.02642
801	beta-catenin (pro2286). [swissprot;acc:p35222]	High confidence	224.445	214.894	1.04445
	programmed cell death protein 6 (probable calcium-binding protein alg- 2). [swissprot;acc:o75340]	Low confidence	202.522	197.311	1.02641
802	dc12 protein. [refseq;acc:nm_020187]		203.345	198.117	1.02639
	testis-specific protein tex28. [swissprot;acc:o15482]	High confidence	212.386	221.785	1.04425
803	dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kda subunit precursor (ec 2.4.1.119) (ribophorin i) (rpn-i). [swissprot;acc:p04843]	Low confidence	199.573	194.441	1.02639
	similar to nuclear protein e3-3 orf1. [sptrembl;acc:q9bu61]	High confidence	212.386	221.785	1.04425
804	a kindred of iglon. [refseq;acc:nm_173808]
	elongation factor ts, mitochondrial precursor (ef-ts) (ef-tsmt). [swissprot;acc:p43897]	Low confidence	204.519	199.267	1.02636
805	ankyrin-repeat family a protein 2 (rfxank-like 2). [swissprot;acc:q9h9e1]	High confidence	212.386	221.785	1.04425
	synaptojanin 1 (ec 3.1.3.36) (synaptic inositol-1,4,5-trisphosphate 5- phosphatase 1). [swissprot;acc:o43426]	Low confidence	198.496	193.399	1.02635
806	inflammation-related g protein-coupled receptor ex33. [refseq;acc:nm_020370]	High confidence	212.386	221.785	1.04425
	vacuolar atp synthase subunit c (ec 3.6.3.14) (v-atpase c subunit) (vacuolar proton pump c subunit). [swissprot;acc:p21283]	Low confidence	202.369	197.173	1.02635
807	myofibrillogenesis regulator 1; trans-activated by hepatitis c virus core protein 2; likely ortholog of mouse brain protein 17. [refseq;acc:nm_022572]		200.782	195.631	1.02633
	palmitoyl-protein thioesterase 1 precursor (ec 3.1.2.22) (palmitoyl- protein hydrolase 1). [swissprot;acc:p50897]	High confidence	212.386	221.785	1.04425
808	beta-soluble nsf attachment protein (snap-beta) (n-ethylmaleimide- sensitive factor attachment protein, beta). [swissprot;acc:q9h115]
	vigilin (high density lipoprotein-binding protein) (hdl-binding protein). [swissprot;acc:q00341]	Low confidence	201.169	196.014	1.0263
809	serine/threonine-protein kinase pak 1 (ec 2.7.1.-) (p21-activated kinase 1) (pak-1) (p65-pak) (alpha-pak). [swissprot;acc:q13153]		202.744	197.552	1.02628
	syntaxin 16 (syn16). [swissprot;acc:o14662]	High confidence	212.386	221.785	1.04425
810	27 kda golgi snare protein (golgi snap receptor complex member 2) (membrin). [swissprot;acc:o14653]
	amyloid beta precursor protein-binding protein 1; amyloid protein-binding protein 1. [refseq;acc:nm_003905]	Low confidence	196.326	191.3	1.02627
811	syntaxin 1a (neuron-specific antigen hpc-1). [swissprot;acc:q16623]	High confidence	212.386	221.785	1.04425
	syntaxin 1b. [swissprot;acc:q15531]	Low confidence	211.432	206.021	1.02626
812	alpha-soluble nsf attachment protein (snap-alpha) (n-ethylmaleimide- sensitive factor attachment protein, alpha). [swissprot;acc:p54920]	High confidence	212.386	221.785	1.04425
	zinc transporter 1 (znt-1). [swissprot;acc:q9y6m5]	Low confidence	206.173	200.909	1.0262

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.