MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Gene	Rank	Filtered	description	Network Comparison Type	Value Type	Interaction Map	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 51 to 100 of 3730 in total

Network Comparison Type  : Divided
Value Type  : Ranked
Interaction Map  : High confidence

Rank	Filtered	description	red	green	network_comparison
26	0	dystrobrevin binding protein 1; dysbindin. [refseq;acc:nm_032122]	12128.3	7533.33	1.60995
	1	pantothenate kinase 3 (ec 2.7.1.33) (pantothenic acid kinase 3) (hpank3). [swissprot;acc:q9h999]	58	44	1.31818
27	0	ptd016 protein. [refseq;acc:nm_016125]	18050	11234	1.60673
	1	mitochondrial solute carrier protein. [refseq;acc:nm_145305]	58	44	1.31818
28	0	p28 ing5. [refseq;acc:nm_032329]	12124.8	7562.05	1.60337
	1	cyclic-amp-dependent transcription factor atf-3 (activating transcription factor 3). [swissprot;acc:p18847]	201.949	153.671	1.31416
29	0	phenylethanolamine n-methyltransferase (ec 2.1.1.28) (pnmtase) (noradrenaline n-methyltransferase). [swissprot;acc:p11086]	7395	11625	1.57201
	1	uncharacterized hematopoietic stem/progenitor cells protein mds026. [sptrembl;acc:q9nz48]	187.458	243.678	1.29991
30	0	beta-carotene dioxygenase 2; putative b,b-carotene-9',10'-dioxygenase. [refseq;acc:nm_031938]	7395	11625	1.57201
	1	serine/threonine protein phosphatase 2a, 55 kda regulatory subunit b, alpha isoform (pp2a, subunit b, b-alpha isoform) (pp2a, subunit b, b55-alpha isoform) (pp2a, subunit b, pr55-alpha isoform) (pp2a, subunit b, r2-alpha isoform). [swissprot;acc:q00007]	187.457	243.678	1.29991
31	0	leucine rich repeat (in flii) interacting protein 1. [refseq;acc:nm_004735]	8082.33	5266.67	1.53462
	1	serine/threonine protein phosphatase 2a, 55 kda regulatory subunit b, beta isoform (pp2a, subunit b, b-beta isoform) (pp2a, subunit b, b55- beta isoform) (pp2a, subunit b, pr55-beta isoform) (pp2a, subunit b, r2-beta isoform). [swissprot;acc:q00005]	187.458	243.677	1.2999
32	0	importin 9. [refseq;acc:nm_018085]	13292.2	8691.76	1.52929
	1	serine/threonine protein phosphatase 2a, 55 kda regulatory subunit b, gamma isoform (pp2a, subunit b, b-gamma isoform) (pp2a, subunit b, b55-gamma isoform) (pp2a, subunit b, pr55-gamma isoform) (pp2a, subunit b, r2-gamma isoform) (imypno1). [swissprot;acc:q9y2t4]	187.462	243.673	1.29985
33	0	nucleosome assembly protein 1-like 4 (nucleosome assembly protein 2) (nap2). [swissprot;acc:q99733]	13292.2	8691.76	1.52929
	1	serine/threonine protein phosphatase 2a, 65 kda regulatory subunit a, beta isoform (pp2a, subunit a, pr65-beta isoform) (pp2a, subunit a, r1-beta isoform). [swissprot;acc:p30154]	188.688	242.742	1.28647
34	0	microtubule-associated protein, rp/eb family, member 2; t-cell activation protein, eb1 family; apc-binding protein eb1. [refseq;acc:nm_014268]	11284	17173.8	1.52196
	1	serine/threonine protein phosphatase 2a, 65 kda regulatory subunit a, alpha isoform (pp2a, subunit a, pr65-alpha isoform) (pp2a, subunit a, r1-alpha isoform) (medium tumor antigen-associated 61 kda protein). [swissprot;acc:p30153]	189.07	242.453	1.28235
35	0	nuclear dna-binding protein; small unique nuclear receptor corepressor; c1d dna-binding protein. [refseq;acc:nm_006333]	3208.8	4871.6	1.5182
	1	nuclear transcription factor y subunit gamma (nf-y protein chain c) (nuclear factor yc) (nf-yc) (ccaat-binding transcription factor subunit c) (cbf-c) (transactivator hsm-1/2). [swissprot;acc:q13952]	260.532	204.309	1.27519
36	0	guanine nucleotide-binding protein beta subunit-like protein 1 (g protein beta-subunit like protein 1) (wd40 repeat containing protein deleted in vcfs) (wdvcf protein) (fksg1 protein) (dgcrk3). [swissprot;acc:q9byb4]	22422	14964	1.4984
	1	ccaat-binding transcription factor subunit b (cbf-b) (nf-y protein chain a) (nf-ya) (caat-box dna binding protein subunit a). [swissprot;acc:p23511]	260.532	204.309	1.27519
37	0	dj570f3.6 (novel protein similar to lysophospholipase ii (lypla2)). [sptrembl;acc:q9uge0]	3859	2582	1.49458
	1	protein phosphatase 1, regulatory (inhibitor) subunit 14a; 17-kda pkc-potentiated inhibitory protein of pp1. [refseq;acc:nm_033256]	322	253	1.27273
38	0	cell division protein kinase 8 (ec 2.7.1.-) (protein kinase k35). [swissprot;acc:p49336]	7230	10771	1.48976
	1	microfibril-associated glycoprotein 4 precursor. [swissprot;acc:p55083]	322	253	1.27273
39	0	ero1-like. [refseq;acc:nm_014584]	13853	20536	1.48242
	1	protein phosphatase 1, regulatory subunit 14d; pkc-dependent pp1 inhibitory protein. [refseq;acc:nm_017726]	322	253	1.27273
40	0	filamin a (alpha-filamin) (filamin 1) (endothelial actin-binding protein) (abp-280) (nonmuscle filamin). [swissprot;acc:p21333]	3845	5699	1.48218
	1	ficolin 2 precursor (collagen/fibrinogen domain-containing protein 2) (ficolin-b) (ficolin b) (serum lectin p35) (ebp-37) (hucolin) (l- ficolin). [swissprot;acc:q15485]	322	253	1.27273
41	0	60s ribosomal protein l21. [swissprot;acc:p46778]	9994.33	6758.83	1.47871
	1	protein phosphatase 1, regulatory (inhibitor) subunit 14c; serologically defined breast cancer antigen ny-br-81; pkc-potentiated pp1 inhibitory protein. [refseq;acc:nm_030949]	322	253	1.27273
42	0	adp,atp carrier protein, liver isoform t2 (adp/atp translocase 3) (adenine nucleotide translocator 3) (ant 3). [swissprot;acc:p12236]	8158	5530.5	1.47509
	1	proto-oncogene protein c-fos (cellular oncogene fos) (g0/g1 switch regulatory protein 7). [swissprot;acc:p01100]	204.641	160.957	1.2714
43	0	glutathione s-transferase theta 2 (ec 2.5.1.18) (gst class-theta). [swissprot;acc:p30712]	12143.8	8356.02	1.4533
	1	jun dimerization protein. [refseq;acc:nm_130469]	204.641	160.957	1.2714
44	0	serpin b12. [swissprot;acc:q96p63]	14604.2	21138.6	1.44743
	1	fos-related antigen 2. [swissprot;acc:p15408]	204.641	161.046	1.2707
45	0	hurpin (hacat uv-repressible serpin) (protease inhibitor 13) (headpin) (serpin b13). [swissprot;acc:q9uiv8]	14592	21113.7	1.44694
	1	protein fosb (g0/g1 switch regulatory protein 3). [swissprot;acc:p53539]	204.641	161.051	1.27066
46	0	60s ribosomal protein l37a. [swissprot;acc:p12751]	12941.7	18499.2	1.42943
	1	fos-related antigen 1 (fra-1). [swissprot;acc:p15407]	204.642	161.068	1.27053
47	0	25-hydroxyvitamin d-1 alpha hydroxylase, mitochondrial precursor (ec 1.14.-.-) (25-ohd-1 alpha-hydroxylase) (25-hydroxyvitamin d3 1- alpha-hydroxylase) (vd3 1a hydroxylase) (p450c1 alpha) (p450vd1- alpha). [swissprot;acc:o15528]	12941.7	18499.2	1.42943
	1	gbp protein isoform a. [refseq;acc:nm_017870]	325.586	256.492	1.26938
48	0	nadh-ubiquinone oxidoreductase 13 kda-b subunit (ec 1.6.5.3) (ec 1.6.99.3) (complex i-13kd-b) (ci-13kd-b) (complex i subunit b13). [swissprot;acc:q16718]	9830	6909	1.42278
	1	gaba(a) receptor-associated protein; gaba(a)-receptor-associated protein. [refseq;acc:nm_007278]	65.4586	83.0461	1.26868
49	0	brain protein 16. [refseq;acc:nm_016458]	6890.54	4854.99	1.41927
	1	beta-arrestin 2 (arrestin, beta 2). [swissprot;acc:p32121]	133	105	1.26667
50	0	cartilage oligomeric matrix protein precursor (comp). [swissprot;acc:p49747]	9249.73	13091.4	1.41533
	1	beta-arrestin 1 (arrestin, beta 1). [swissprot;acc:p49407]	133	105	1.26667

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.