MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Hugo	Network Comparison Type	Value Type	red	Interaction Map	Filtered	green	network_comparison

Results: HTML CSV LaTeX

Showing element 682 to 731 of 12912 in total

Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Hugo	Value Type	red	green	network_comparison
171	lag1 longevity assurance homolog 2 isoform 1; l3 pigment; tumor metastasis-suppressor. [refseq;acc:nm_022075]	LASS2	Rooted	61.6639	71.7355	1.16333
	melanoma-associated antigen d2 (mage-d2 antigen) (breast cancer associated gene 1 protein) (bcg-1) (11b6) (hepatocellular carcinoma associated protein jcl-1). [swissprot;acc:q9unf1]	MAGED2	Measured	23693.7	18263	1.29736
	nucleolysin tiar (tia-1 related protein). [swissprot;acc:q01085]	TIAL1	Ranked	227.202	192.823	1.17829
172	cg9578-like; yeast ypr037w and worm c02c2.6 predicted proteins-like. [refseq;acc:nm_152902]	TIPRL		174.667	205.556	1.17685
	likely ortholog of mouse variant polyadenylation protein cstf-64. [refseq;acc:nm_015235]	CSTF2T	Squared	121579	87259.3	1.39331
	splicing factor 3b subunit 1 (spliceosome associated protein 155) (sap 155) (sf3b155) (pre-mrna splicing factor sf3b 155 kda subunit). [swissprot;acc:o75533]	SF3B1	Rooted	56.7592	65.9889	1.16261
	trophinin. [swissprot;acc:q12816]	TRO	Measured	23693.7	18263	1.29736
173	28s ribosomal protein s17, mitochondrial precursor (mrp-s17) (hspc011). [swissprot;acc:q9y2r5]	MRPS17	Rooted	145.551	168.796	1.1597
	breast cancer antiestrogen resistance 3. [refseq;acc:nm_003567]	BCAR3	Measured	4579.34	5940.64	1.29727
	septin 4 (peanut-like protein 2) (brain protein h5) (cell division control-related protein 2) (hcdcrel-2) (bradeion beta) (ce5b3 beta) (cerebral protein-7) (hucep-7). [swissprot;acc:o43236]	SEPT4	Squared	82624.3	115061	1.39258
	small nuclear ribonucleoprotein sm d1 (snrnp core protein d1) (sm-d1) (sm-d autoantigen). [swissprot;acc:p13641]	SNRPD1	Ranked	227.032	193.056	1.17599
174	dgcr14 protein (digeorge syndrome critical region 14) (es2 protein). [swissprot;acc:q96df8]	DGCR14		335	286	1.17133
	mad protein (max dimerizer). [swissprot;acc:q05195]	MXD1	Measured	4455.95	5774.03	1.2958
	pantothenate kinase 1 (ec 2.7.1.33) (pantothenic acid kinase 1) (hpank1) (hpank). [swissprot;acc:q8te04]	PANK1	Rooted	145.551	168.796	1.1597
	sedlin. [swissprot;acc:o14582]	ZNF547	Squared	112820	157033	1.39189
175	cop9 constitutive photomorphogenic homolog subunit 3; cop9 complex subunit 3; jab1-containing signalosome subunit 3. [refseq;acc:nm_003653]	COPS3	Ranked	199.949	234.187	1.17123
	max interacting protein 1 (mxi1 protein). [swissprot;acc:p50539]	MXI1	Measured	4456.67	5773.77	1.29553
	pantothenate kinase 2, mitochondrial precursor (ec 2.7.1.33) (pantothenic acid kinase 2) (hpank2). [swissprot;acc:q9bz23]	PANK2	Rooted	145.551	168.796	1.1597
	synbindin (trs23 homolog) (hematopoietic stem/progenitor cell protein 172) (hspc172) (ptd009) (cgi-104). [swissprot;acc:q9y296]	no value	Squared	112820	157033	1.39189
176	bet3 homolog. [swissprot;acc:o43617]	TRAPPC3
	dna polymerase epsilon p12 subunit (dna polymerase epsilon subunit 4). [swissprot;acc:q9nr33]	POLE4	Ranked	275.754	235.908	1.1689
	max-interacting transcriptional repressor mad4 (max-associated protein 4) (max dimerization protein 4). [swissprot;acc:q14582]	MXD4	Measured	4456.93	5773.67	1.29544
	pantothenate kinase 3 (ec 2.7.1.33) (pantothenic acid kinase 3) (hpank3). [swissprot;acc:q9h999]	PANK3	Rooted	145.551	168.796	1.1597
177	dj820b18.1 (similar to nuclear cap binding protein) (fragment). [sptrembl;acc:q8wwk2]	NCBP2L	Ranked	229.406	196.695	1.1663
	max dimerization protein 3; likely ortholog of mouse max dimerization protein 3. [refseq;acc:nm_031300]	RAB24	Measured	4457.06	5773.63	1.29539
	mitochondrial solute carrier protein. [refseq;acc:nm_145305]	SLC25A43	Rooted	145.551	168.796	1.1597
	septin 1 (larp) (serologically defined breast cancer antigen ny-br- 24). [swissprot;acc:q8wyj6]	SEPT1	Squared	78383	108483	1.38401
178	carboxypeptidase b precursor. [refseq;acc:nm_020361]	CPA6		25326.4	18354.1	1.37988
	formin binding protein 3; fas-ligand associated factor 1; huntingtin-interacting protein a; ny-ren-6 antigen. [refseq;acc:nm_017892]	no value	Ranked	226.887	194.72	1.1652
	myosin vb (myosin 5b) (fragment). [swissprot;acc:q9ulv0]	MYO5B	Measured	21591.5	27904.5	1.29238
	transcription factor dp-2 (e2f dimerization partner 2). [swissprot;acc:q14188]	TFDP2	Rooted	45.7414	52.932	1.1572
179	huntingtin-interacting protein hypa/fbp11 (fragment). [sptrembl;acc:o75404]	no value	Ranked	226.884	194.79	1.16476
	mast cell carboxypeptidase a precursor (ec 3.4.17.1) (mc-cpa) (carboxypeptidase a3). [swissprot;acc:p15088]	CPA3	Squared	25326.3	18354.1	1.37987
	myosin vc (myosin 5c). [swissprot;acc:q9nqx4]	MYO5C	Measured	21591.5	27904.5	1.29238
	palmitoyl-protein thioesterase 2 precursor (ec 3.1.2.22) (palmitoyl- protein hydrolase 2) (ppt-2) (g14). [swissprot;acc:q9umr5]	EGFL8	Rooted	50.272	43.4634	1.15665
180	egf-like-domain, multiple 7; neu1 protein. [refseq;acc:nm_016215]	EGFL7		50.2801	43.4779	1.15645
	myosin va (myosin 5a) (dilute myosin heavy chain, non-muscle) (myosin heavy chain 12) (myoxin). [swissprot;acc:q9y4i1]	no value	Measured	21591.5	27904.5	1.29238
	plasma carboxypeptidase b2 isoform a preproprotein; carboxypeptidase u; thrombin-activatable fibrinolysis inhibitor; carboxypeptidase b-like protein; thrombin-activable fibrinolysis inhibitor. [refseq;acc:nm_001872]	CPB2	Squared	25326.2	18354.1	1.37987
	tar dna-binding protein-43 (tdp-43). [swissprot;acc:q13148]	TARDBP	Ranked	256.228	298.438	1.16474
181	b9 protein; likely ortholog of mouse endothelial precursor protein b9. [refseq;acc:nm_015681]	B9D1		229.818	267.265	1.16294
	crk-associated substrate (p130cas) (breast cancer anti-estrogen resistance 1 protein). [swissprot;acc:p56945]	BCAR1	Rooted	57.4432	66.3307	1.15472
	eukaryotic translation initiation factor 4 gamma, 3. [refseq;acc:nm_003760]	EIF4G3	Measured	4068.56	5252.6	1.29102
	hira-interacting protein 5 (cgi-33). [swissprot;acc:q9ums0]	NFU1	Squared	55630.4	76083.7	1.36766
182	deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial precursor (ec 3.6.1.23) (dutpase) (dutp pyrophosphatase). [swissprot;acc:p33316]	DUT		61733.5	45224.1	1.36506
	histone acetyltransferase type b catalytic subunit (ec 2.3.1.48). [swissprot;acc:o14929]	HAT1	Ranked	277.546	240.461	1.15422
	rna-binding protein. [refseq;acc:nm_019027]	no value	Measured	4069.83	5252.17	1.29051
	t-complex protein 1, delta subunit (tcp-1-delta) (cct-delta) (stimulator of tar rna binding). [swissprot;acc:p50991]	CCT4	Rooted	57.45	66.332	1.1546
183	20 kda nuclear cap binding protein (ncbp 20 kda subunit) (cbp20) (ncbp interacting protein 1) (nip1). [swissprot;acc:p52298]	NCBP2	Ranked	228.306	198.011	1.153
	acyl-coa dehydrogenase, very-long-chain specific, mitochondrial precursor (ec 1.3.99.-) (vlcad). [swissprot;acc:p49748]	ACADVL	Squared	79779.8	108084	1.35478
	apobec-1 complementation factor isoform 1; apobec-1 stimulating protein; apo-b rna editing protein. [refseq;acc:nm_014576]	no value	Measured	4069.83	5252.17	1.29051

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.