Scientific

MK5 Microarray Data


Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

  • value_type as 'ranked' since this provides a very robust analysis method.
  • intercation map as 'high confidence'
  • network_comparison type as 'Divided' since this leads to a natural grouping of similar proteins
  • filtered as 'true' since this will only use the microarray measurements that have a sufficiently large confidence level.

  • Navigation/Query Panel:
    Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].
    Rank Gene description Value Type Network Comparison Type Interaction Map Filtered red green network_comparison
    Results: HTML CSV LaTeX Showing element 2093 to 2142 of 3228 in total
    Value Type	Measured
    Network Comparison Type Divided
    Interaction Map High confidence
    Filtered 1
    Rank description red green network_comparison 2093 fuse binding protein 3 (fragment). [source:sptrembl;acc:q92946] 5817.56 6138.9 1.05524 2094 nuclease sensitive element binding protein 1 (y box binding protein-1) (y-box transcription factor) (yb-1) (ccaat-binding transcription factor i subunit a) (cbf-a) (enhancer factor i subunit a) (efi-a) (dna-binding protein b) (dbpb). [source:swissprot;acc:p16991] 6682.05 7051.02 1.05522 2095 dna-binding protein a (cold shock domain protein a) (single-strand dna binding protein nf-gmb). [source:swissprot;acc:p16989] 6682.05 7051.02 1.05522 2096 germ cell specific y-box binding protein; contrin. [source:refseq;acc:nm_015982] 6682.05 7051.02 1.05522 2097 polypeptide n-acetylgalactosaminyltransferase 2; udp-galnac transferase 2. [source:refseq;acc:nm_004481] 6024.47 6356.56 1.05512 2098 similar to expressed sequence ai415388 (fragment). [source:sptrembl;acc:q8n428] 6024.47 6356.56 1.05512 2099 methionine aminopeptidase 1 (ec 3.4.11.18) (metap 1) (map 1) (peptidase m 1). [source:swissprot;acc:p53582] 3544.03 3359.43 1.05495 2100 methionine aminopeptidase 2 (ec 3.4.11.18) (metap 2) (peptidase m 2) (initiation factor 2 associated 67 kda glycoprotein) (p67) (p67eif2). [source:swissprot;acc:p50579] 3544.03 3359.43 1.05495 2101 maguk p55 subfamily member 2 (mpp2 protein) (discs, large homolog 2). [source:swissprot;acc:q14168] 5241.34 5529.25 1.05493 2102 c-1-tetrahydrofolate synthase, cytoplasmic (c1-thf synthase) [includes: methylenetetrahydrofolate dehydrogenase (ec 1.5.1.5); methenyltetrahydrofolate cyclohydrolase (ec 3.5.4.9); formyltetrahydrofolate synthetase (ec 6.3.4.3)]. [source:swissprot;acc:p11586] 4860.34 5127.3 1.05493 2103 asparaginyl-trna synthetase, cytoplasmic (ec 6.1.1.22) (asparagine-- trna ligase) (asnrs). [source:swissprot;acc:o43776] 6847.82 7223.51 1.05486 2104 protein disulfide isomerase precursor (pdi) (ec 5.3.4.1) (prolyl 4- hydroxylase beta subunit) (cellular thyroid hormone binding protein) (p55). [source:swissprot;acc:p07237] 6916.14 7295.24 1.05481 2105 3-hydroxyanthranilate 3,4-dioxygenase (ec 1.13.11.6) (3-hao) (3-hydroxyanthranilic acid dioxygenase) (3-hydroxyanthranilate oxygenase). [source:swissprot;acc:p46952] 6916.14 7295.24 1.05481 2106 zinc finger protein-like 1; zinc-finger protein in men1 region. [source:refseq;acc:nm_006782] 6916.14 7295.24 1.05481 2107 hus1 checkpoint protein; hus1 (s. pombe) checkpoint homolog; hus1+-like protein. [source:refseq;acc:nm_004507] 6916.14 7295.24 1.05481 2108 hyaluronan binding protein 4; intracellular antigen detected by monoclonal antibody ki-1; intracellular hyaluronan-binding protein; chromodomain helicase dna binding protein 3 interacting protein. [source:refseq;acc:nm_014282] 6916.14 7295.24 1.05481 2109 prolyl 4-hydroxylase alpha-1 subunit precursor (ec 1.14.11.2) (4-ph alpha-1) (procollagen-proline,2-oxoglutarate-4-dioxygenase alpha-1 subunit). [source:swissprot;acc:p13674] 6916.14 7295.24 1.05481 2110 homeobox prospero-like protein prox1 (prox 1). [source:swissprot;acc:q92786] 6916.14 7295.24 1.05481 2111 rad1 homolog isoform 1; exonuclease homolog rad1; cell cycle checkpoint protein rad1 a/b; rad1-like protein; cell cycle checkpoint protein hrad1; dna repair exonuclease (rec1); dna repair protein rad1; rad1-like dna damage checkpoint protein. [source:refseq;acc:nm_002853] 6916.14 7295.24 1.05481 2112 prolyl 4-hydroxylase alpha-2 subunit precursor (ec 1.14.11.2) (4-ph alpha-2) (procollagen-proline,2-oxoglutarate-4-dioxygenase alpha-2 subunit). [source:swissprot;acc:o15460] 6916.14 7295.24 1.05481 2113 rna-binding protein 9 (rna binding motif protein 9) (hexaribonucleotide binding protein 2) (repressor of tamoxifen transcriptional activity). [source:swissprot;acc:o43251] 5776.79 6092.77 1.0547 2114 60s ribosomal protein l3-like. [source:swissprot;acc:q92901] 3617.81 3430.31 1.05466 2115 60s ribosomal protein l23 (l17). [source:swissprot;acc:p23131] 3672.49 3482.34 1.0546 2116 brca2 and cdkn1a-interacting protein isoform bccipalpha; brca2 and cdkn1a-interacting protein; cdk inhibitor p21 binding protein; bccipalpha; bccipbeta; tok-1alpha; tok-1beta. [source:refseq;acc:nm_016567] 3672.49 3482.34 1.0546 2117 ataxin 2-binding protein. [source:swissprot;acc:q9nwb1] 5778.16 6093.65 1.0546 2118 guanylate kinase (ec 2.7.4.8) (gmp kinase). [source:swissprot;acc:q16774] 5620.55 5926.71 1.05447 2119 lamin a/c (70 kda lamin). [source:swissprot;acc:p02545] 5976.96 6301.73 1.05434 2120 c316g12.2 (novel protein similar to predicted yeast, worm and archae- bacterial proteins) (similar to und313) (s. cervisiae) (hypothetical protein). [source:sptrembl;acc:q9ujk0] 6951.29 7329 1.05434 2121 centaurin beta 5 (cnt-b5). [source:swissprot;acc:q96p50] 5977.03 6301.76 1.05433 2122 centaurin beta 2 (cnt-b2). [source:swissprot;acc:q15057] 5977.03 6301.76 1.05433 2123 centaurin beta 1 (cnt-b1). [source:swissprot;acc:q15027] 5977.03 6301.76 1.05433 2124 lamin b1. [source:swissprot;acc:p20700] 5977.09 6301.79 1.05432 2125 ribosomal protein s27-like protein; 40s ribosomal protein s27 isoform. [source:refseq;acc:nm_015920] 4806.38 5067 1.05422 2126 40s ribosomal protein s27 (metallopan-stimulin 1) (mps-1). [source:swissprot;acc:p42677] 4806.33 5066.92 1.05422 2127 eukaryotic translation initiation factor 3 subunit 11 (eif-3 p25) (eif3k) (muscle specific gene m9 protein) (ptd001) (hspc029) (arg134). [source:swissprot;acc:q9ubq5] 5328.73 5616.59 1.05402 2128 erythroid differentiation and denucleation factor 1. [source:swissprot;acc:o60584] 5328.73 5616.59 1.05402 2129 bardet-biedl syndrome 7 protein isoform a; bbs2-like 1. [source:refseq;acc:nm_176824] 5328.73 5616.59 1.05402 2130 ba508n22.1 (hspc025) (fragment). [source:sptrembl;acc:q9hcw5] 5328.73 5616.59 1.05402 2131 lipopolysaccharide-responsive and beige-like anchor protein (cdc4-like protein) (beige-like protein). [source:swissprot;acc:p50851] 5328.73 5616.59 1.05402 2132 protein c20orf45 (cgi-107). [source:swissprot;acc:q9y3b1] 5328.73 5616.59 1.05402 2133 eukaryotic translation initiation factor 3 subunit 6 interacting protein (hspc021/hspc025). [source:swissprot;acc:q9y262] 5328.73 5616.59 1.05402 2134 putative rna-binding protein 7 (rna binding motif protein 7). [source:swissprot;acc:q9y580] 5328.73 5616.59 1.05402 2135 exocyst complex component sec6. [source:swissprot;acc:o60645] 7387.42 7785.45 1.05388 2136 60s ribosomal protein l19. [source:swissprot;acc:p14118] 3687.49 3499.2 1.05381 2137 sh3 domain-binding glutamic acid-rich protein (sh3bgr protein) (21- glutamic acid-rich protein) (21-garp). [source:swissprot;acc:p55822] 5859.1 6173.7 1.05369 2138 oxidation resistance 1. [source:refseq;acc:nm_181354] 5859.1 6173.7 1.05369 2139 lats, large tumor suppressor, homolog 2; lats (large tumor suppressor, drosophila) homolog 2. [source:refseq;acc:nm_014572] 5859.1 6173.7 1.05369 2140 dymeclin. [source:refseq;acc:nm_017653] 5859.1 6173.7 1.05369 2141 sh3 domain-binding glutamic acid-rich-like protein. [source:swissprot;acc:o75368] 5859.1 6173.7 1.05369 2142 lats homolog 1. [source:refseq;acc:nm_004690] 5859.1 6173.7 1.05369 Legend: - Rank is the rank after comparing the two networks - Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions. - Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them - Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions. - Filtered specifies whether we only included the high confidence microarry measurements or not.

    - http://analysis.yellowcouch.org/