MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Network Comparison Type	Value Type	Hugo	description	Interaction Map	network_comparison	Filtered	red	green

Results: HTML CSV LaTeX

Showing element 1 to 50 of 33156 in total

Network Comparison Type  : Divided
Filtered  : 1

Rank	Value Type	Hugo	description	Interaction Map	network_comparison	red	green
1	Measured	LAMP1	lysosome-associated membrane glycoprotein 1 precursor (lamp-1) (cd107a antigen). [swissprot;acc:p11279]	Low confidence	4.4149	2399.5	543.5
		RINT1	rad50-interacting protein 1. [refseq;acc:nm_021930]	High confidence	5.31521	450.5	2394.5
	Ranked	CPD	carboxypeptidase d precursor (ec 3.4.17.-) (gp180). [swissprot;acc:o75976]	Low confidence	2	16	32
		UBAC1	putative glialblastoma cell differentiation-related; putative glialblastoma cell differentiation-related protein. [refseq;acc:nm_016172]	High confidence	2.4	10	24
	Squared	LAMP1	lysosome-associated membrane glycoprotein 1 precursor (lamp-1) (cd107a antigen). [swissprot;acc:p11279]	Low confidence	19.4914	1362.75	69.9153
		RINT1	rad50-interacting protein 1. [refseq;acc:nm_021930]	High confidence	28.2513	48.0356	1357.07
	Rooted	LAMP1	lysosome-associated membrane glycoprotein 1 precursor (lamp-1) (cd107a antigen). [swissprot;acc:p11279]	Low confidence	2.10117	48.9847	23.3131
		RINT1	rad50-interacting protein 1. [refseq;acc:nm_021930]	High confidence	2.30547	21.225	48.9336
2	Measured	CDK4	cell division protein kinase 4 (ec 2.7.1.37) (cyclin-dependent kinase 4) (psk-j3). [swissprot;acc:p11802]	Low confidence	4.4149	2399.5	543.5
		RHOBTB2	rho-related btb domain-containing protein 2 (deleted in breast cancer 2 gene protein) (p83). [swissprot;acc:q9byz6]	High confidence	5.31521	450.5	2394.5
	Ranked	no value	mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476]		1.86667	15	28
		LAMP1	lysosome-associated membrane glycoprotein 1 precursor (lamp-1) (cd107a antigen). [swissprot;acc:p11279]	Low confidence	1.47982	223	330
	Squared	CDK4	cell division protein kinase 4 (ec 2.7.1.37) (cyclin-dependent kinase 4) (psk-j3). [swissprot;acc:p11802]		19.4914	1362.75	69.9153
		RHOBTB2	rho-related btb domain-containing protein 2 (deleted in breast cancer 2 gene protein) (p83). [swissprot;acc:q9byz6]	High confidence	28.2513	48.0356	1357.07
	Rooted	CDK4	cell division protein kinase 4 (ec 2.7.1.37) (cyclin-dependent kinase 4) (psk-j3). [swissprot;acc:p11802]	Low confidence	2.10117	48.9847	23.3131
		RHOBTB2	rho-related btb domain-containing protein 2 (deleted in breast cancer 2 gene protein) (p83). [swissprot;acc:q9byz6]	High confidence	2.30547	21.225	48.9336
3	Measured	CDK6	cell division protein kinase 6 (ec 2.7.1.37) (serine/threonine protein kinase plstire). [swissprot;acc:q00534]	Low confidence	4.4149	2399.5	543.5
		HLX	homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774]	High confidence	3.71868	2597.5	698.5
	Ranked	CDK4	cell division protein kinase 4 (ec 2.7.1.37) (cyclin-dependent kinase 4) (psk-j3). [swissprot;acc:p11802]	Low confidence	1.47982	223	330
		PSCD1	cytohesin 1 (sec7 homolog b2-1). [swissprot;acc:q15438]	High confidence	1.86667	15	28
	Squared	CDK6	cell division protein kinase 6 (ec 2.7.1.37) (serine/threonine protein kinase plstire). [swissprot;acc:q00534]	Low confidence	19.4914	1362.75	69.9153
		HLX	homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774]	High confidence	13.8285	1596.92	115.48
	Rooted	CDK6	cell division protein kinase 6 (ec 2.7.1.37) (serine/threonine protein kinase plstire). [swissprot;acc:q00534]	Low confidence	2.10117	48.9847	23.3131
		HLX	homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774]	High confidence	1.92839	50.9657	26.4292
4	Measured	HBS1L	hbs1-like. [refseq;acc:nm_006620]		3.71868	2597.5	698.5
		LAMP2	lysosome-associated membrane glycoprotein 2 precursor (lamp-2) (cd107b antigen). [swissprot;acc:p13473]	Low confidence	4.4149	2399.5	543.5
	Ranked	CDK6	cell division protein kinase 6 (ec 2.7.1.37) (serine/threonine protein kinase plstire). [swissprot;acc:q00534]		1.47982	223	330
		PSCD2	cytohesin 2 (arf nucleotide-binding site opener) (arno protein) (arf exchange factor). [swissprot;acc:q99418]	High confidence	1.86667	15	28
	Squared	HBS1L	hbs1-like. [refseq;acc:nm_006620]		13.8285	1596.92	115.48
		LAMP2	lysosome-associated membrane glycoprotein 2 precursor (lamp-2) (cd107b antigen). [swissprot;acc:p13473]	Low confidence	19.4914	1362.75	69.9153
	Rooted	HBS1L	hbs1-like. [refseq;acc:nm_006620]	High confidence	1.92839	50.9657	26.4292
		LAMP2	lysosome-associated membrane glycoprotein 2 precursor (lamp-2) (cd107b antigen). [swissprot;acc:p13473]	Low confidence	2.10117	48.9847	23.3131
5	Measured	JPH3	junctophilin 3 (junctophilin type 3) (jp-3). [swissprot;acc:q8wxh2]	High confidence	3.39764	1153.5	339.5
		OSBPL6	oxysterol binding protein-related protein 6 (osbp-related protein 6) (orp-6). [swissprot;acc:q9bzf3]	Low confidence	2.86965	736.5	2113.5
	Ranked	LAMP2	lysosome-associated membrane glycoprotein 2 precursor (lamp-2) (cd107b antigen). [swissprot;acc:p13473]		1.47982	223	330
		PSCD4	cytohesin 4. [swissprot;acc:q9uia0]	High confidence	1.86667	15	28
	Squared	JPH3	junctophilin 3 (junctophilin type 3) (jp-3). [swissprot;acc:q8wxh2]		11.544	314.926	27.2805
		OSBPL6	oxysterol binding protein-related protein 6 (osbp-related protein 6) (orp-6). [swissprot;acc:q9bzf3]	Low confidence	8.23493	128.386	1057.25
	Rooted	JPH3	junctophilin 3 (junctophilin type 3) (jp-3). [swissprot;acc:q8wxh2]	High confidence	1.84327	33.9632	18.4255
		OSBPL6	oxysterol binding protein-related protein 6 (osbp-related protein 6) (orp-6). [swissprot;acc:q9bzf3]	Low confidence	1.69401	27.1385	45.9728
6	Measured	JPH2	junctophilin 2 (junctophilin type 2) (jp-2). [swissprot;acc:q9br39]	High confidence	3.39764	1153.5	339.5
		OSBPL3	oxysterol binding protein-related protein 3 (osbp-related protein 3) (orp-3). [swissprot;acc:q9h4l5]	Low confidence	2.86965	736.5	2113.5
	Ranked	OSBPL6	oxysterol binding protein-related protein 6 (osbp-related protein 6) (orp-6). [swissprot;acc:q9bzf3]		1.325	318	240
		PSCD3	cytohesin 3 (arf nucleotide-binding site opener 3) (arno3 protein) (general receptor of phosphoinositides 1) (grp1). [swissprot;acc:o43739]	High confidence	1.86667	15	28
	Squared	JPH2	junctophilin 2 (junctophilin type 2) (jp-2). [swissprot;acc:q9br39]		11.544	314.926	27.2805
		OSBPL3	oxysterol binding protein-related protein 3 (osbp-related protein 3) (orp-3). [swissprot;acc:q9h4l5]	Low confidence	8.23493	128.386	1057.25
	Rooted	JPH2	junctophilin 2 (junctophilin type 2) (jp-2). [swissprot;acc:q9br39]	High confidence	1.84327	33.9632	18.4255
		OSBPL3	oxysterol binding protein-related protein 3 (osbp-related protein 3) (orp-3). [swissprot;acc:q9h4l5]	Low confidence	1.69401	27.1385	45.9728
7	Measured	OSBPL7	oxysterol binding protein-related protein 7 (osbp-related protein 7) (orp-7). [swissprot;acc:q9bzf2]		2.86965	736.5	2113.5
		SMPD2	sphingomyelin phosphodiesterase 2 (ec 3.1.4.12) (neutral sphingomyelinase) (nsmase) (n-smase) (lyso-platelet activating factor- phospholipase c) (lyso-paf-plc). [swissprot;acc:o60906]	High confidence	3.39764	1153.5	339.5

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.