MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Network Comparison Type	Hugo	Value Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1 to 50 of 25824 in total

Interaction Map  : High confidence
Filtered  : 1

Rank	description	Network Comparison Type	Hugo	Value Type	red	green	network_comparison
1	homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774]	Subtracted	HLX	Ranked	215	322	107
	mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476]		no value	Measured	41482.5	33356.5	8126
	putative glialblastoma cell differentiation-related; putative glialblastoma cell differentiation-related protein. [refseq;acc:nm_016172]	Divided	UBAC1	Ranked	10	24	2.4
		Subtracted		Squared	468498	322755	145743
	rad50-interacting protein 1. [refseq;acc:nm_021930]	Divided	RINT1	Measured	450.5	2394.5	5.31521
				Squared	48.0356	1357.07	28.2513
				Rooted	21.225	48.9336	2.30547
		Subtracted					27.7086
2	cytohesin 1 (sec7 homolog b2-1). [swissprot;acc:q15438]		PSCD1	Measured	41482.5	33356.5	8126
	hbs1-like. [refseq;acc:nm_006620]		HBS1L	Ranked	215	322	107
	mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476]	Divided	no value		15	28	1.86667
		Subtracted		Squared	407289	263351	143938
	rho-related btb domain-containing protein 2 (deleted in breast cancer 2 gene protein) (p83). [swissprot;acc:q9byz6]	Divided	RHOBTB2	Measured	450.5	2394.5	5.31521
				Squared	48.0356	1357.07	28.2513
				Rooted	21.225	48.9336	2.30547
		Subtracted					27.7086
3	cytohesin 1 (sec7 homolog b2-1). [swissprot;acc:q15438]	Divided	PSCD1	Ranked	15	28	1.86667
		Subtracted		Squared	407289	263351	143938
	cytohesin 2 (arf nucleotide-binding site opener) (arno protein) (arf exchange factor). [swissprot;acc:q99418]		PSCD2	Measured	41482.5	33356.5	8126
	homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774]	Divided	HLX		2597.5	698.5	3.71868
				Squared	1596.92	115.48	13.8285
				Rooted	50.9657	26.4292	1.92839
		Subtracted					24.5365
	rad50-interacting protein 1. [refseq;acc:nm_021930]		RINT1	Ranked	337	232	105
4	cytohesin 2 (arf nucleotide-binding site opener) (arno protein) (arf exchange factor). [swissprot;acc:q99418]	Divided	PSCD2		15	28	1.86667
		Subtracted		Squared	407289	263351	143938
	cytohesin 4. [swissprot;acc:q9uia0]		PSCD4	Measured	41482.5	33356.5	8126
	hbs1-like. [refseq;acc:nm_006620]	Divided	HBS1L		2597.5	698.5	3.71868
				Squared	1596.92	115.48	13.8285
				Rooted	50.9657	26.4292	1.92839
		Subtracted					24.5365
	rho-related btb domain-containing protein 2 (deleted in breast cancer 2 gene protein) (p83). [swissprot;acc:q9byz6]		RHOBTB2	Ranked	337	232	105
5	28s ribosomal protein s17, mitochondrial precursor (mrp-s17) (hspc011). [swissprot;acc:q9y2r5]		MRPS17	Rooted	145.551	168.796	23.245
	cytohesin 3 (arf nucleotide-binding site opener 3) (arno3 protein) (general receptor of phosphoinositides 1) (grp1). [swissprot;acc:o43739]		PSCD3	Measured	41482.5	33356.5	8126
	cytohesin 4. [swissprot;acc:q9uia0]	Divided	PSCD4	Ranked	15	28	1.86667
		Subtracted		Squared	407289	263351	143938
	junctophilin 3 (junctophilin type 3) (jp-3). [swissprot;acc:q8wxh2]	Divided	JPH3	Measured	1153.5	339.5	3.39764
				Squared	314.926	27.2805	11.544
				Rooted	33.9632	18.4255	1.84327
	xpa binding protein 1; mbd2 interactor protein; putative atp(gtp)-binding protein. [refseq;acc:nm_007266]	Subtracted	XAB1	Ranked	212	309	97
6	cytohesin 3 (arf nucleotide-binding site opener 3) (arno3 protein) (general receptor of phosphoinositides 1) (grp1). [swissprot;acc:o43739]	Divided	PSCD3		15	28	1.86667
		Subtracted		Squared	407289	263351	143938
	junctophilin 2 (junctophilin type 2) (jp-2). [swissprot;acc:q9br39]	Divided	JPH2	Measured	1153.5	339.5	3.39764
				Squared	314.926	27.2805	11.544
				Rooted	33.9632	18.4255	1.84327
	pantothenate kinase 1 (ec 2.7.1.33) (pantothenic acid kinase 1) (hpank1) (hpank). [swissprot;acc:q8te04]	Subtracted	PANK1		145.551	168.796	23.245
	protein x 0004. [refseq;acc:nm_016301]		ATPBD1C	Ranked	212	309	97
	putative glialblastoma cell differentiation-related; putative glialblastoma cell differentiation-related protein. [refseq;acc:nm_016172]		UBAC1	Measured	44490.5	36927.5	7563
7	28s ribosomal protein s17, mitochondrial precursor (mrp-s17) (hspc011). [swissprot;acc:q9y2r5]		MRPS17		21185	28492	7307
	homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774]	Divided	HLX	Ranked	215	322	1.49767

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.