MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Gene	Rank	Value Type	description	green	red	Network Comparison Type	Interaction Map	Filtered	network_comparison

Results: HTML CSV LaTeX

Showing element 51 to 100 of 25824 in total

Interaction Map  : High confidence
Filtered  : 1

Rank	Value Type	description	green	red	Network Comparison Type	network_comparison
7	Ranked	homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774]	322	215	Divided	1.49767
		protein cgi-126 (protein hspc155). [swissprot;acc:q9y3c8]	212.554	288.754	Subtracted	76.2
	Squared	nuclear dna-binding protein; small unique nuclear receptor corepressor; c1d dna-binding protein. [refseq;acc:nm_006333]	442993	310840		132153
		sphingomyelin phosphodiesterase 2 (ec 3.1.4.12) (neutral sphingomyelinase) (nsmase) (n-smase) (lyso-platelet activating factor- phospholipase c) (lyso-paf-plc). [swissprot;acc:o60906]	27.2805	314.926	Divided	11.544
	Rooted	pantothenate kinase 2, mitochondrial precursor (ec 2.7.1.33) (pantothenic acid kinase 2) (hpank2). [swissprot;acc:q9bz23]	168.796	145.551	Subtracted	23.245
		sphingomyelin phosphodiesterase 2 (ec 3.1.4.12) (neutral sphingomyelinase) (nsmase) (n-smase) (lyso-platelet activating factor- phospholipase c) (lyso-paf-plc). [swissprot;acc:o60906]	18.4255	33.9632	Divided	1.84327
8	Measured	db83 protein. [swissprot;acc:p57088]	339.5	1153.5		3.39764
		pantothenate kinase 1 (ec 2.7.1.33) (pantothenic acid kinase 1) (hpank1) (hpank). [swissprot;acc:q8te04]	28492	21185	Subtracted	7307
	Ranked	hbs1-like. [refseq;acc:nm_006620]	322	215	Divided	1.49767
		junctophilin 3 (junctophilin type 3) (jp-3). [swissprot;acc:q8wxh2]	362	288	Subtracted	74
	Squared	db83 protein. [swissprot;acc:p57088]	27.2805	314.926	Divided	11.544
		deoxyribonuclease ii beta isoform 1 precursor; deoxyribonuclease ii beta; endonuclease dlad. [refseq;acc:nm_021233]	354894	250303	Subtracted	104591
	Rooted	db83 protein. [swissprot;acc:p57088]	18.4255	33.9632	Divided	1.84327
		pantothenate kinase 3 (ec 2.7.1.33) (pantothenic acid kinase 3) (hpank3). [swissprot;acc:q9h999]	168.796	145.551	Subtracted	23.245
9	Measured	pantothenate kinase 2, mitochondrial precursor (ec 2.7.1.33) (pantothenic acid kinase 2) (hpank2). [swissprot;acc:q9bz23]	28492	21185		7307
		tob2 protein (transducer of erbb-2 2). [swissprot;acc:q14106]	1281.5	398.5	Divided	3.21581
	Ranked	junctophilin 2 (junctophilin type 2) (jp-2). [swissprot;acc:q9br39]	362	288	Subtracted	74
		xpa binding protein 1; mbd2 interactor protein; putative atp(gtp)-binding protein. [refseq;acc:nm_007266]	309	212	Divided	1.45755
	Squared	protein phosphatase 1, regulatory subunit 7; sds22. [refseq;acc:nm_002712]	162517	256169	Subtracted	93652
		tob2 protein (transducer of erbb-2 2). [swissprot;acc:q14106]	388.696	37.5863	Divided	10.3414
	Rooted	mitochondrial solute carrier protein. [refseq;acc:nm_145305]	168.796	145.551	Subtracted	23.245
		tob2 protein (transducer of erbb-2 2). [swissprot;acc:q14106]	35.798	19.9625	Divided	1.79326
10	Measured	pantothenate kinase 3 (ec 2.7.1.33) (pantothenic acid kinase 3) (hpank3). [swissprot;acc:q9h999]	28492	21185	Subtracted	7307
		tob1 protein (transducer of erbb-2 1). [swissprot;acc:p50616]	1281.5	398.5	Divided	3.21581
	Ranked	protein x 0004. [refseq;acc:nm_016301]	309	212		1.45755
		sphingomyelin phosphodiesterase 2 (ec 3.1.4.12) (neutral sphingomyelinase) (nsmase) (n-smase) (lyso-platelet activating factor- phospholipase c) (lyso-paf-plc). [swissprot;acc:o60906]	362	288	Subtracted	74
	Squared	melanoma antigen, family d, 4 isoform 1; mage1 protein; mage-e1 protein; maged4 protein. [refseq;acc:nm_030801]	129762	219048		89286
		tob1 protein (transducer of erbb-2 1). [swissprot;acc:p50616]	388.696	37.5863	Divided	10.3414
	Rooted		35.798	19.9625		1.79326
		xpa binding protein 1; mbd2 interactor protein; putative atp(gtp)-binding protein. [refseq;acc:nm_007266]	29.5127	51.6817	Subtracted	22.169
11	Measured	dab2 interacting protein; ngap-like protein; doc-2/dab2 interactive protein. [refseq;acc:nm_032552]	1281.5	398.5	Divided	3.21581
		mitochondrial solute carrier protein. [refseq;acc:nm_145305]	28492	21185	Subtracted	7307
	Ranked	db83 protein. [swissprot;acc:p57088]	362	288		74
		rad50-interacting protein 1. [refseq;acc:nm_021930]	232	337	Divided	1.45259
	Squared	dab2 interacting protein; ngap-like protein; doc-2/dab2 interactive protein. [refseq;acc:nm_032552]	388.696	37.5863		10.3414
		hepatocellular carcinoma-associated protein hca3. [refseq;acc:nm_138703]	129762	219048	Subtracted	89286
	Rooted	dab2 interacting protein; ngap-like protein; doc-2/dab2 interactive protein. [refseq;acc:nm_032552]	35.798	19.9625	Divided	1.79326
		protein x 0004. [refseq;acc:nm_016301]	29.5127	51.6817	Subtracted	22.169
12	Measured	cytoplasmic polyadenylation element binding protein 4. [refseq;acc:nm_030627]	1281.5	398.5	Divided	3.21581
		nuclear dna-binding protein; small unique nuclear receptor corepressor; c1d dna-binding protein. [refseq;acc:nm_006333]	40795.8	34190.9	Subtracted	6604.9
	Ranked	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-7 subunit. [swissprot;acc:o60262]	336.233	266.856		69.377
		rho-related btb domain-containing protein 2 (deleted in breast cancer 2 gene protein) (p83). [swissprot;acc:q9byz6]	232	337	Divided	1.45259
	Squared	cytoplasmic polyadenylation element binding protein 4. [refseq;acc:nm_030627]	388.696	37.5863		10.3414
		melanoma-associated antigen 3 (mage-3 antigen) (antigen mz2-d). [swissprot;acc:p43357]	129762	219048	Subtracted	89286
	Rooted	beta-arrestin 2 (arrestin, beta 2). [swissprot;acc:p32121]	101.526	80.4705		21.0555
		cytoplasmic polyadenylation element binding protein 4. [refseq;acc:nm_030627]	35.798	19.9625	Divided	1.79326
13	Measured	cytoplasmic polyadenylation element binding protein 3. [refseq;acc:nm_014912]	1281.5	398.5		3.21581
		myosin vb (myosin 5b) (fragment). [swissprot;acc:q9ulv0]	27904.5	21591.5	Subtracted	6313
	Ranked	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-12 subunit. [swissprot;acc:q9ubi6]	336.233	266.856		69.377
		protein cgi-126 (protein hspc155). [swissprot;acc:q9y3c8]	212.554	288.754	Divided	1.3585

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.