MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Value Type	description	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 758 to 807 of 25824 in total

Interaction Map  : High confidence
Filtered  : 1

Rank	Value Type	description	Network Comparison Type	red	green	network_comparison
95	Squared	tumor suppressor p53-binding protein 2 (p53-binding protein 2) (53bp2) (bcl2-binding protein) (bbp). [swissprot;acc:q13625]	Subtracted	123324	86277.9	37046.1
	Rooted	guanine nucleotide-binding protein g(t), alpha-2 subunit (transducin alpha-2 chain). [swissprot;acc:p19087]		40.2804	24.3692	15.9112
		regulator of g-protein signaling 19 (rgs19) (g-alpha interacting protein) (gaip protein). [swissprot;acc:p49795]	Divided	47.6504	36.9304	1.29028
96	Measured	lag1 longevity assurance homolog 2 isoform 1; l3 pigment; tumor metastasis-suppressor. [refseq;acc:nm_022075]		4110.14	5694.99	1.3856
		septin-like protein kiaa0202 (fragment). [swissprot;acc:q92599]	Subtracted	16177.9	19235.4	3057.5
	Ranked	cyclic-amp-dependent transcription factor atf-3 (activating transcription factor 3). [swissprot;acc:p18847]		201.949	153.671	48.278
		melanoma-associated antigen 8 (mage-8 antigen). [swissprot;acc:p43361]	Divided	88.2482	110.265	1.24949
	Squared	atlastin; guanylate-binding protein 3. [refseq;acc:nm_015915]		7744.68	4959.41	1.56161
		septin-like protein kiaa0202 (fragment). [swissprot;acc:q92599]	Subtracted	90226	126939	36713
	Rooted	guanine nucleotide-binding protein g(i), alpha-2 subunit (adenylate cyclase-inhibiting g alpha protein). [swissprot;acc:p04899]		40.28	24.37	15.91
		putative rna-binding protein 15 (rna binding motif protein 15) (one-twenty two protein). [swissprot;acc:q96t37]	Divided	47.6504	36.9304	1.29028
97	Measured	amyloid beta a4 precursor protein-binding family a member 1 (neuron- specific x11 protein) (neuronal munc18-1-interacting protein 1) (mint-1) (adapter protein x11alpha). [swissprot;acc:q02410]		2820.51	3897.1	1.3817
		septin 10 isoform 1. [refseq;acc:nm_144710]	Subtracted	16067.4	19094.4	3027
	Ranked	amyloid beta a4 precursor protein-binding family a member 1 (neuron- specific x11 protein) (neuronal munc18-1-interacting protein 1) (mint-1) (adapter protein x11alpha). [swissprot;acc:q02410]		271.752	225.68	46.072
		melanoma-associated antigen c1 (mage-c1 antigen) (cancer-testis antigen ct7). [swissprot;acc:o60732]	Divided	88.2482	110.265	1.24949
	Squared	cleavage and polyadenylation specific factor 4, 30kd subunit; cleavage-polyadenylation specificity factor, 30kd; no arches-like (zebrafish) zinc finger protein; cleavage-polyadenylation specificity factor. [refseq;acc:nm_006693]		227160	146079	1.55505
		cleavage stimulation factor, 64 kda subunit (cstf 64 kda subunit) (cf-1 64 kda subunit). [swissprot;acc:p33240]	Subtracted	126408	89940.5	36467.5
	Rooted	guanine nucleotide-binding protein g(i), alpha-1 subunit (adenylate cyclase-inhibiting g alpha protein). [swissprot;acc:p04898]		40.2797	24.3705	15.9092
		regulator of g-protein signaling 20 (rgs20) (regulator of gz- selective protein signaling 1) (gz-selective gtpase-activating protein) (g(z)gap). [swissprot;acc:o76081]	Divided	47.6504	36.9304	1.29028
98	Measured	brain protein 44. [swissprot;acc:o95563]	Subtracted	15999.1	19007.1	3008
		presenilin 2 (ps-2) (stm-2) (e5-1) (ad3lp) (ad5). [swissprot;acc:p49810]	Divided	2353.63	3225.65	1.3705
	Ranked	melanoma-associated antigen 12 (mage-12 antigen) (mage12f). [swissprot;acc:p43365]		88.2482	110.265	1.24949
		proto-oncogene protein c-fos (cellular oncogene fos) (g0/g1 switch regulatory protein 7). [swissprot;acc:p01100]	Subtracted	204.641	160.957	43.684
	Squared	septin 10 isoform 1. [refseq;acc:nm_144710]		89578.7	125883	36304.3
		trs85 homolog. [swissprot;acc:q9y2l5]	Divided	227160	146079	1.55505
	Rooted	guanine nucleotide-binding protein g(k), alpha subunit (g(i) alpha-3). [swissprot;acc:p08754]	Subtracted	40.2797	24.3705	15.9092
		transcription factor lbx1. [swissprot;acc:p52954]	Divided	47.6504	36.9304	1.29028
99	Measured	s-phase kinase-associated protein 1a (cyclin a/cdk2-associated protein p19) (p19a) (p19skp1) (rna polymerase ii elongation factor-like protein) (organ of corti protein 2) (ocp-ii protein) (ocp-2) (transcription elongation factor b) (siii). [swissprot;acc:p34991]		2353.63	3225.65	1.3705
		septin 7 (cdc10 protein homolog). [swissprot;acc:q16181]	Subtracted	15999.1	19007.1	3008
	Ranked	jun dimerization protein. [refseq;acc:nm_130469]		204.641	160.957	43.684
		melanoma-associated antigen 1 (mage-1 antigen) (antigen mz2-e). [swissprot;acc:p43355]	Divided	88.2482	110.265	1.24949
	Squared	brain protein 44. [swissprot;acc:o95563]	Subtracted	89182.8	125229	36046.2
		wd-repeat protein wdc146. [swissprot;acc:q9c0j8]	Divided	226186	145568	1.55382
	Rooted	mosaic protein lgn. [swissprot;acc:p81274]		47.6504	36.9304	1.29028
		tob2 protein (transducer of erbb-2 2). [swissprot;acc:q14106]	Subtracted	19.9625	35.798	15.8355
100	Measured	f-box protein fbw7 isoform 2; archipelago, drosophila, homolog of; f-box protein fbw7; f-box protein sel-10; homolog of c elegans sel-10. [refseq;acc:nm_018315]	Divided	2353.63	3225.65	1.3705
		septin 6. [swissprot;acc:q14141]	Subtracted	15959.9	18957.1	2997.2
	Ranked	fos-related antigen 2. [swissprot;acc:p15408]		204.641	161.046	43.595
		melanoma-associated antigen 10 (mage-10 antigen). [swissprot;acc:p43363]	Divided	88.2482	110.265	1.24949
	Squared	cleavage and polyadenylation specificity factor, 160 kda subunit (cpsf 160 kda subunit). [swissprot;acc:q10570]		226186	145568	1.55382
		septin 7 (cdc10 protein homolog). [swissprot;acc:q16181]	Subtracted	89182.8	125229	36046.2
	Rooted	regulator of g-protein signaling 17 (rgs17). [swissprot;acc:q9ugc6]	Divided	47.6504	36.9304	1.29028
		tob1 protein (transducer of erbb-2 1). [swissprot;acc:p50616]	Subtracted	19.9625	35.798	15.8355
101	Measured	cullin homolog 2 (cul-2). [swissprot;acc:q13617]	Divided	2353.63	3225.65	1.3705
		septin 4 (peanut-like protein 2) (brain protein h5) (cell division control-related protein 2) (hcdcrel-2) (bradeion beta) (ce5b3 beta) (cerebral protein-7) (hucep-7). [swissprot;acc:o43236]	Subtracted	14924.4	17655.2	2730.8
	Ranked	melanoma-associated antigen b1 (mage-b1 antigen) (mage-xp antigen) (dss-ahc critical interval mage superfamily 10) (dam10). [swissprot;acc:p43366]	Divided	88.2482	110.265	1.24949
		protein fosb (g0/g1 switch regulatory protein 3). [swissprot;acc:p53539]	Subtracted	204.641	161.051	43.59
	Squared	cleavage and polyadenylation specificity factor, 100 kda subunit (cpsf 100 kda subunit) (fragment). [swissprot;acc:q9p2i0]	Divided	222655	143584	1.5507
		septin 6. [swissprot;acc:q14141]	Subtracted	88953.6	124854	35900.4
	Rooted	dab2 interacting protein; ngap-like protein; doc-2/dab2 interactive protein. [refseq;acc:nm_032552]		19.9625	35.798	15.8355

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.