MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Hugo	Network Comparison Type	Value Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 501 to 550 of 16578 in total

Value Type  : Ranked
Filtered  : 1

Rank	description	Hugo	Network Comparison Type	Interaction Map	red	green	network_comparison
126	associated molecule with the sh3 domain of stam (amsh) like protein. [refseq;acc:nm_020799]	STAMBPL1	Divided	High confidence	94	114	1.21277
	f-box protein fbw7 isoform 2; archipelago, drosophila, homolog of; f-box protein fbw7; f-box protein sel-10; homolog of c elegans sel-10. [refseq;acc:nm_018315]	FBXW7	Subtracted		285.684	252.234	33.45
	lag1 longevity assurance homolog 2 isoform 1; l3 pigment; tumor metastasis-suppressor. [refseq;acc:nm_022075]	LASS2	Divided	Low confidence	191.688	179.639	1.06707
	nadh-ubiquinone oxidoreductase 18 kda subunit, mitochondrial precursor (ec 1.6.5.3) (ec 1.6.99.3) (complex i-18 kda) (ci-18 kda) (complex i- aqdq) (ci-aqdq). [swissprot;acc:o43181]	NDUFS4	Subtracted		226.892	213.661	13.231
127	adenomatous polyposis coli protein (apc protein). [swissprot;acc:p25054]	APC			222.31	235.538	13.228
	cullin homolog 2 (cul-2). [swissprot;acc:q13617]	CUL2		High confidence	285.684	252.234	33.45
	putative breast adenocarcinoma marker (32kd). [refseq;acc:nm_014453]	CHMP2A	Divided		94	114	1.21277
	vacuolar protein sorting 33b (hvps33b). [swissprot;acc:q9h267]	VPS33B		Low confidence	203.678	190.88	1.06705
128	adenomatous polyposis coli like. [refseq;acc:nm_005883]	APC2	Subtracted		222.34	235.547	13.207
	associated molecule with the sh3 domain of stam. [refseq;acc:nm_006463]	STAMBP	Divided	High confidence	94	114	1.21277
	presenilin 1 (ps-1) (s182 protein). [swissprot;acc:p49768]	PSEN1	Subtracted		285.684	252.234	33.45
	striatin. [swissprot;acc:o43815]	STRN	Divided	Low confidence	214.085	200.796	1.06618
129	cullin homolog 1 (cul-1). [swissprot;acc:q13616]	CUL1	Subtracted	High confidence	285.684	252.234	33.45
	goodpasture antigen-binding protein (ec 2.7.1.37) (gpbp) (collagen type iv alpha 3 binding protein) (star-related lipid transfer protein 11) (stard11) (start domain-containing protein 11). [swissprot;acc:q9y5p4]	COL4A3BP	Divided	Low confidence	220.969	235.572	1.06609
	neuroendocrine differentiation factor; comparative gene identification transcript 149. [refseq;acc:nm_016079]	VPS24		High confidence	94	114	1.21277
	transgelin (smooth muscle protein 22-alpha) (sm22-alpha) (ws3-10) (22 kda actin-binding protein). [swissprot;acc:q01995]	TAGLN	Subtracted	Low confidence	218.561	205.431	13.13
130	neuronal protein np25. [swissprot;acc:q9ui15]	TAGLN3			218.66	205.57	13.09
	palmitoyl-protein thioesterase 2 precursor (ec 3.1.2.22) (palmitoyl- protein hydrolase 2) (ppt-2) (g14). [swissprot;acc:q9umr5]	EGFL8		High confidence	242.735	276.059	33.324
	protein hspc134 (protein cda04). [swissprot;acc:q9by43]	CHMP4A	Divided		94	114	1.21277
	striated muscle activator of rho-dependent signaling. [refseq;acc:nm_139166]	ABRA		Low confidence	225.495	211.529	1.06602
131	egf-like-domain, multiple 7; neu1 protein. [refseq;acc:nm_016215]	EGFL7	Subtracted	High confidence	242.718	276.018	33.3
	son protein (son3) (negative regulatory element-binding protein) (nre- binding protein) (dbp-5) (bax antagonist selected in saccharomyces 1) (bass1) (protein c21orf50). [swissprot;acc:p18583]	SON	Divided		294.053	242.562	1.21228
	striatin 4 (zinedin). [swissprot;acc:q9nrl3]	STRN4		Low confidence	213.878	200.825	1.065
			Subtracted				13.053
132	daz associated protein 1 isoform b; deleted in azoospermia associated protein 1. [refseq;acc:nm_018959]	DAZAP1	Divided		220.268	206.997	1.06411
	dj820b18.1 (similar to nuclear cap binding protein) (fragment). [sptrembl;acc:q8wwk2]	NCBP2L	Subtracted	High confidence	229.406	196.695	32.711
	segment polarity protein dishevelled homolog dvl-1 (dishevelled-1) (dsh homolog 1). [swissprot;acc:o14640]	DVL1		Low confidence	203.016	189.965	13.051
	tob2 protein (transducer of erbb-2 2). [swissprot;acc:q14106]	TOB2	Divided	High confidence	350	290	1.2069
133	formin binding protein 3; fas-ligand associated factor 1; huntingtin-interacting protein a; ny-ren-6 antigen. [refseq;acc:nm_017892]	no value	Subtracted		226.887	194.72	32.167
	prominin-like protein 1 precursor (antigen ac133) (cd133 antigen). [swissprot;acc:o43490]	PROM1	Divided	Low confidence	220.268	206.997	1.06411
	segment polarity protein dishevelled homolog dvl-2 (dishevelled-2) (dsh homolog 2). [swissprot;acc:o14641]	DVL2	Subtracted		203.007	189.985	13.022
	tob1 protein (transducer of erbb-2 1). [swissprot;acc:p50616]	TOB1	Divided	High confidence	350	290	1.2069
134	dab2 interacting protein; ngap-like protein; doc-2/dab2 interactive protein. [refseq;acc:nm_032552]	DAB2IP
	huntingtin-interacting protein hypa/fbp11 (fragment). [sptrembl;acc:o75404]	no value	Subtracted		226.884	194.79	32.094
	transgelin (smooth muscle protein 22-alpha) (sm22-alpha) (ws3-10) (22 kda actin-binding protein). [swissprot;acc:q01995]	TAGLN	Divided	Low confidence	218.561	205.431	1.06391
	transgelin 2 (sm22-alpha homolog). [swissprot;acc:p37802]	no value	Subtracted		218.36	205.4	12.96
135	cytoplasmic polyadenylation element binding protein 4. [refseq;acc:nm_030627]	CPEB4	Divided	High confidence	350	290	1.2069
	forkhead box p4; fork head-related protein like a; winged-helix repressor foxp4. [refseq;acc:nm_138457]	FOXP4	Subtracted		263.215	231.407	31.808
	neuronal protein np25. [swissprot;acc:q9ui15]	TAGLN3	Divided	Low confidence	218.66	205.57	1.06368
	segment polarity protein dishevelled homolog dvl-3 (dishevelled-3) (dsh homolog 3). [swissprot;acc:q92997]	DVL3	Subtracted		202.96	190.094	12.866
136	cytoplasmic polyadenylation element binding protein 3. [refseq;acc:nm_014912]	CPEB3	Divided	High confidence	350	290	1.2069
	forkhead box protein p1 (hspc215). [swissprot;acc:q9h334]	FOXP1	Subtracted		263.215	231.407	31.808
	high-mobility group 20b; sox-like transcriptional factor; swi/snf-related matrix-associated actin-dependent regulator of chromatin subfamily e, member 1-related. [refseq;acc:nm_006339]	HMG20B	Divided	Low confidence	202.996	190.854	1.06362
	rho guanine nucleotide exchange factor 7 (pak-interacting exchange factor beta) (beta-pix) (cool-1) (p85). [swissprot;acc:q14155]	ARHGEF7	Subtracted		219.344	206.52	12.824
137	forkhead box protein p3 (zinc finger protein jm2) (scurfin). [swissprot;acc:q9bzs1]	FOXP3		High confidence	263.191	231.394	31.797
	ras gtpase-activating protein ngap (ras protein activator like 1). [swissprot;acc:q9ujf2]	RASAL2	Divided		350	290	1.2069
	testican-3 precursor. [swissprot;acc:q9bq16]	no value		Low confidence	220.395	234.389	1.0635
	vacuolar protein sorting 33b (hvps33b). [swissprot;acc:q9h267]	VPS33B	Subtracted		203.678	190.88	12.798
138	cg9578-like; yeast ypr037w and worm c02c2.6 predicted proteins-like. [refseq;acc:nm_152902]	TIPRL		High confidence	174.667	205.556	30.889
	rho guanine nucleotide exchange factor 6 (pak-interacting exchange factor alpha) (alpha-pix) (cool-2). [swissprot;acc:q15052]	ARHGEF6		Low confidence	219.273	206.507	12.766

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.