MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Rank	Gene	Value Type	description	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 408 to 457 of 12912 in total

Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

Rank	Value Type	description	red	green	network_comparison
102	Rooted	rap1 gtpase-activating protein 1 (rap1gap). [swissprot;acc:p47736]	47.6504	36.9304	1.29028
103	Measured	cullin homolog 1 (cul-1). [swissprot;acc:q13616]	2353.63	3225.65	1.3705
	Ranked	trophinin. [swissprot;acc:q12816]	88.2482	110.265	1.24949
	Squared	mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476]	407289	263351	1.54656
	Rooted	proto-oncogene protein c-fos (cellular oncogene fos) (g0/g1 switch regulatory protein 7). [swissprot;acc:p01100]	60.8365	77.7233	1.27758
104	Measured	musashi 2 isoform a. [refseq;acc:nm_138962]	4241.57	5810.79	1.36996
	Ranked	homer, neuronal immediate early gene, 2; homer homolog 3 (drosophila). [refseq;acc:nm_004839]	252.371	202.016	1.24926
	Squared	cytohesin 1 (sec7 homolog b2-1). [swissprot;acc:q15438]	407289	263351	1.54656
	Rooted	jun dimerization protein. [refseq;acc:nm_130469]	60.8365	77.7233	1.27758
105	Measured	musashi 1. [refseq;acc:nm_002442]	4241.57	5810.79	1.36996
	Ranked	guanine nucleotide-binding protein g(i)/g(s)/g(t) beta subunit 1 (transducin beta chain 1). [swissprot;acc:p04901]	266.716	333.165	1.24914
	Squared	cytohesin 2 (arf nucleotide-binding site opener) (arno protein) (arf exchange factor). [swissprot;acc:q99418]	407289	263351	1.54656
	Rooted	fos-related antigen 2. [swissprot;acc:p15408]	60.8675	77.7168	1.27682
106	Measured	nuclear protein ukp68. [refseq;acc:nm_024824]	4241.57	5810.79	1.36996
	Ranked	ubiquinone biosynthesis protein coq7 homolog (coenzyme q biosynthesis protein 7 homolog) (timing protein clk-1 homolog). [swissprot;acc:q99807]	252.329	202.004	1.24913
	Squared	cytohesin 4. [swissprot;acc:q9uia0]	407289	263351	1.54656
	Rooted	protein fosb (g0/g1 switch regulatory protein 3). [swissprot;acc:p53539]	60.8692	77.7165	1.27678
107	Measured	20 kda nuclear cap binding protein (ncbp 20 kda subunit) (cbp20) (ncbp interacting protein 1) (nip1). [swissprot;acc:p52298]	4266.04	5843.51	1.36977
	Ranked	homer, neuronal immediate early gene, 1b. [refseq;acc:nm_004272]	252.309	201.998	1.24907
	Squared	cytohesin 3 (arf nucleotide-binding site opener 3) (arno3 protein) (general receptor of phosphoinositides 1) (grp1). [swissprot;acc:o43739]	407289	263351	1.54656
	Rooted	fos-related antigen 1 (fra-1). [swissprot;acc:p15407]	60.875	77.7152	1.27664
108	Measured	filamin b, beta (actin binding protein 278); beta filamin; filamin 1 (actin-binding protein-280)-like; filamin b, beta (actin-binding protein-278); filamin b, beta. [refseq;acc:nm_001457]	4366.44	5899.76	1.35116
	Ranked	homer, neuronal immediate early gene, 3. [refseq;acc:nm_004838]	252.296	201.995	1.24902
	Squared	myosin heavy chain, cardiac muscle alpha isoform (myhc-alpha). [swissprot;acc:p13533]	19321	12542.6	1.54043
	Rooted	voltage-dependent calcium channel gamma-2 subunit (neuronal voltage- gated calcium channel gamma-2 subunit). [swissprot;acc:q9y698]	49.2925	62.397	1.26585
109	Measured	rev1-like; rev1 protein; rev1 (yeast homolog)- like. [refseq;acc:nm_016316]	4366.44	5899.76	1.35116
	Ranked	guanine nucleotide-binding protein beta subunit 4 (transducin beta chain 4). [swissprot;acc:q9hav0]	266.933	333.281	1.24856
	Squared	myosin heavy chain, skeletal muscle, fetal (myosin heavy chain iib) (myhc-iib). [swissprot;acc:q9y623]	19321	12542.6	1.54043
	Rooted	voltage-dependent calcium channel gamma-8 subunit (neuronal voltage- gated calcium channel gamma-8 subunit). [swissprot;acc:q8wxs5]	49.2923	62.3969	1.26585
110	Measured	protein arginine n-methyltransferase 1 (ec 2.1.1.-) (interferon receptor 1-bound protein 4). [swissprot;acc:q99873]	4366.44	5899.76	1.35116
	Ranked	deltex 2. [refseq;acc:nm_020892]	333.144	267.393	1.2459
	Squared	myosin heavy chain, skeletal muscle, perinatal (myhc-perinatal). [swissprot;acc:p13535]	19321	12542.6	1.54043
	Rooted	voltage-dependent calcium channel gamma-4 subunit (neuronal voltage- gated calcium channel gamma-4 subunit). [swissprot;acc:q9ubn1]	49.293	62.3973	1.26585
111	Measured	protein arginine n-methyltransferase 4 (ec 2.1.1.-). [swissprot;acc:q9nr22]	4366.44	5899.76	1.35116
	Ranked	deltex homolog 1; hdx-1. [refseq;acc:nm_004416]	332.925	267.274	1.24563
	Squared	myosin heavy chain, skeletal muscle, adult 2 (myosin heavy chain iia) (myhc-iia). [swissprot;acc:q9ukx2]	19321	12542.6	1.54043
	Rooted	voltage-dependent calcium channel gamma-3 subunit (neuronal voltage- gated calcium channel gamma-3 subunit). [swissprot;acc:o60359]	49.2923	62.3969	1.26585
112	Measured	u1 small nuclear ribonucleoprotein 70 kda (u1 snrnp 70 kda) (snrnp70) (u1-70k). [swissprot;acc:p08621]	4366.44	5899.76	1.35116
	Ranked	t-lak cell-originated protein kinase; spermatogenesis-related protein kinase; pdz-binding kinase; pbk; mapkk-like protein kinase; serine/threonine protein kinase. [refseq;acc:nm_018492]	332.874	267.246	1.24557
	Squared	myosin heavy chain, fast skeletal muscle, embryonic (muscle embryonic myosin heavy chain) (smhce). [swissprot;acc:p11055]	19321	12542.6	1.54043
	Rooted	voltage-dependent calcium channel gamma-5 subunit (neuronal voltage- gated calcium channel gamma-5 subunit). [swissprot;acc:q9uf02]	49.3267	62.4167	1.26537
113	Measured	filamin a (alpha-filamin) (filamin 1) (endothelial actin-binding protein) (abp-280) (nonmuscle filamin). [swissprot;acc:p21333]	4366.44	5899.76	1.35116
	Ranked	kh domain containing, rna binding, signal transduction associated 3; sam68-like phosphotyrosine protein, t-star. [refseq;acc:nm_006558]	332.874	267.246	1.24557
	Squared	myosin heavy chain, skeletal muscle, adult 1 (myosin heavy chain iix/d) (myhc-iix/d). [swissprot;acc:p12882]	19321	12542.6	1.54043
	Rooted	beta-arrestin 2 (arrestin, beta 2). [swissprot;acc:p32121]	80.4705	101.526	1.26165
114	Measured	huntingtin interacting protein c. [refseq;acc:nm_012272]	4300.47	5807.72	1.35048
	Ranked	kh domain containing, rna binding, signal transduction associated 1; gap-associated tyrosine phosphoprotein p62 (sam68). [refseq;acc:nm_006559]	332.874	267.246	1.24557
	Squared	myosin heavy chain, cardiac muscle beta isoform (myhc-beta). [swissprot;acc:p12883]	19321	12542.6	1.54043
	Rooted	beta-arrestin 1 (arrestin, beta 1). [swissprot;acc:p49407]	80.4705	101.526	1.26165
115	Measured	28s ribosomal protein s17, mitochondrial precursor (mrp-s17) (hspc011). [swissprot;acc:q9y2r5]	21185	28492	1.34491

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.