Scientific

MK5 Microarray Data


Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

  • value_type as 'ranked' since this provides a very robust analysis method.
  • intercation map as 'high confidence'
  • network_comparison type as 'Divided' since this leads to a natural grouping of similar proteins
  • filtered as 'true' since this will only use the microarray measurements that have a sufficiently large confidence level.

  • Navigation/Query Panel:
    Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].
    Filtered Rank Gene description Value Type Network Comparison Type Interaction Map red network_comparison green
    Results: HTML CSV LaTeX Showing element 51 to 100 of 3730 in total
    Filtered	0
    Value Type Ranked
    Network Comparison Type Divided
    Interaction Map High confidence
    Rank description red network_comparison green 51 importin alpha-2 subunit (karyopherin alpha-2 subunit) (srp1-alpha) (rag cohort protein 1). [source:swissprot;acc:p52292] 7168 1.40494 5102 52 ariadne-2 protein homolog (ari-2) (triad1 protein) (ht005). [source:swissprot;acc:o95376] 3284 1.38688 4554.5 53 ubiquitin-conjugating enzyme e2-18 kda ubch7 (ec 6.3.2.19) (ubiquitin- protein ligase) (ubiquitin carrier protein) (ubcm4) (e2-f1) (l-ubc). [source:swissprot;acc:p51966] 3284 1.38688 4554.5 54 syntaxin 10 (syn10). [source:swissprot;acc:o60499] 13884.4 1.36949 19014.6 55 sedlin. [source:swissprot;acc:o14582] 22440 1.36929 16388 56 synbindin (trs23 homolog) (hematopoietic stem/progenitor cell protein 172) (hspc172) (ptd009) (cgi-104). [source:swissprot;acc:q9y296] 22440 1.36929 16388 57 hsp90 co-chaperone cdc37 (hsp90 chaperone protein kinase-targeting subunit) (p50cdc37). [source:swissprot;acc:q16543] 8152.55 1.36581 11134.8 58 dead-box protein. [source:refseq;acc:nm_018665] 10628.3 1.36296 14486 59 glutamate dehydrogenase 2, mitochondrial precursor (ec 1.4.1.3) (gdh). [source:swissprot;acc:p49448] 15863.6 1.36025 11662.3 60 glucosamine-6-phosphate isomerase (ec 3.5.99.6) (glucosamine-6- phosphate deaminase) (gnpda) (glcn6p deaminase) (oscillin). [source:swissprot;acc:p46926] 11761 1.35397 15924 61 testis-specific protein tpx-1 precursor (cysteine-rich secretory protein-2) (crisp-2). [source:swissprot;acc:p16562] 15352 1.35302 11346.5 62 glycine receptor alpha-3 chain precursor. [source:swissprot;acc:o75311] 9418.7 1.34791 12695.6 63 oligosaccharyl transferase stt3 subunit homolog (b5) (integral membrane protein 1) (tmc). [source:swissprot;acc:p46977] 8519.83 1.34428 11453 64 similar to lysozyme c-1 (1,4-beta-n-acylmuramidase c, ec 3.2.1.17). [source:refseq;acc:nm_032517] 15264 1.33563 20387 65 e1a binding protein p400; p400 swi2/snf2-related protein; cagh32 protein; trinucleotide repeat containing 12. [source:refseq;acc:nm_015409] 7853.67 1.32502 10406.3 66 heparan sulfate 6-o-sulfotransferase 2. [source:refseq;acc:nm_147174] 11461 1.32449 15180 67 presenilin enhancer 2; hematopoietic stem/progenitor cells protein mds033. [source:refseq;acc:nm_172341] 10793.5 1.32408 14291.5 68 purine nucleoside phosphorylase (ec 2.4.2.1) (inosine phosphorylase) (pnp). [source:swissprot;acc:p00491] 8932.56 1.32362 11823.3 69 collagen alpha 5(iv) chain precursor. [source:swissprot;acc:p29400] 7704.7 1.32051 10174.1 70 protein regulator of cytokinesis 1; protein regulating cytokinesis 1. [source:refseq;acc:nm_003981] 13975.7 1.31931 10593.2 71 nucleoporin nup43 (p42). [source:swissprot;acc:q8nfh3] 4338.65 1.31395 5700.79 72 putative phosphoglycerate mutase 3 (ec 5.4.2.1) (ec 5.4.2.4) (ec 3.1.3.13). [source:swissprot;acc:q8n0y7] 4119 1.31027 5397 73 phosphoglycerate mutase 1 (ec 5.4.2.1) (ec 5.4.2.4) (ec 3.1.3.13) (phosphoglycerate mutase isozyme b) (pgam-b) (bpg-dependent pgam 1). [source:swissprot;acc:p18669] 4119 1.31027 5397 74 ataxin 2; olivopontocerebellar ataxia 2, autosomal dominant. [source:refseq;acc:nm_002973] 6742.5 1.29915 8759.5 75 nanos (fragment). [source:sptrembl;acc:q8wy41] 8782 1.29242 11350 76 spectrin alpha chain, brain (spectrin, non-erythroid alpha chain) (alpha-ii spectrin) (fodrin alpha chain). [source:swissprot;acc:q13813] 3474 1.28905 2695 77 regulator of chromosome condensation (cell cycle regulatory protein). [source:swissprot;acc:p18754] 8821.32 1.28853 11366.5 78 repressor of estrogen receptor activity; b-cell associated protein. [source:refseq;acc:nm_007273] 7584.72 1.27969 9706.12 79 nuclear rna export factor 5 (tap-like protein 1) (tapl-1). [source:swissprot;acc:q9h1b4] 9465.55 1.27901 12106.5 80 deltex homolog 1; hdx-1. [source:refseq;acc:nm_004416] 9102.34 1.27636 11617.9 81 selenide,water dikinase 2 (ec 2.7.9.3) (selenophosphate synthetase 2) (selenium donor protein 2). [source:swissprot;acc:q99611] 14463 1.2736 11356 82 dj681n20.2 (novel protein similar to ferritin, light polypeptide (ftl)). [source:sptrembl;acc:q9byw6] 7706.5 1.27212 6058 83 small nuclear ribonucleoprotein associated proteins b and b' (snrnp-b) (sm protein b/b') (sm-b/sm-b') (smb/smb'). [source:swissprot;acc:p14678] 18359.8 1.27077 14447.8 84 syntaxin 1a (neuron-specific antigen hpc-1). [source:swissprot;acc:q16623] 12460.6 1.26647 15781 85 transducin beta-like 2 protein (ws beta-transducin repeats protein) (ws-betatrp) (williams-beuren syndrome chromosome region 13 protein). [source:swissprot;acc:q9y4p3] 9688.47 1.24934 12104.2 86 high mobility group protein 1 (hmg-1). [source:swissprot;acc:p09429] 5677.96 1.24876 4546.87 87 dj579f20.1 (high-mobility group (nonhistone chromosomal) protein 1-like 1). [source:sptrembl;acc:q9nqj4] 5677.89 1.24859 4547.43 88 high mobility group protein 1-like 10 (hmg-1l10). [source:swissprot;acc:q9ugv6] 5677.86 1.24852 4547.66 89 nuclear autoantigen sp-100 (speckled 100 kda) (nuclear dot-associated sp100 protein) (lysp100b). [source:swissprot;acc:p23497] 5677.58 1.24786 4549.85 90 high mobility group protein 4-like (hmg-4l). [source:swissprot;acc:q9uj13] 5677.45 1.24755 4550.87 91 bone morphogenetic protein 8 precursor (bmp-8) (osteogenic protein 2) (op-2). [source:swissprot;acc:p34820] 13841.2 1.24387 11127.5 92 dok-like protein. [source:refseq;acc:nm_024872] 17571 1.23971 21783 93 pms1 protein homolog 2 (dna mismatch repair protein pms2). [source:swissprot;acc:p54278] 7739.47 1.23793 9580.95 94 transketolase-like 1 (ec 2.2.1.1) (transketolase 2) (tk 2) (transketolase related protein). [source:swissprot;acc:p51854] 12946.3 1.23067 10519.7 95 pp3111 protein. [source:refseq;acc:nm_022156] 6185 1.22926 7603 96 imp2 inner mitochondrial membrane protease-like; inner mitochondrial membrane peptidase 2 like. [source:refseq;acc:nm_032549] 8335.82 1.22703 10228.3 97 microsomal signal peptidase 18 kda subunit (ec 3.4.-.-) (spase 18 kda subunit) (spc18) (endopeptidase sp18). [source:swissprot;acc:p21378] 8335.82 1.22703 10228.3 98 orphan nuclear receptor nr2e1 (nuclear receptor tlx) (tailless homolog) (tll) (htll). [source:swissprot;acc:q9y466] 7234.6 1.22452 8858.94 99 muscle-specific beta 1 integrin binding protein. [source:refseq;acc:nm_014446] 12787.8 1.22316 10454.7 100 creatine kinase, ubiquitous mitochondrial precursor (ec 2.7.3.2) (u- mtck) (mia-ck) (acidic-type mitochondrial creatine kinase). [source:swissprot;acc:p12532] 9183.49 1.22151 11217.7 Legend: - Rank is the rank after comparing the two networks - Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions. - Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them - Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions. - Filtered specifies whether we only included the high confidence microarry measurements or not.

    - http://analysis.yellowcouch.org/