MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	Value Type	Filtered	description	Network Comparison Type	Interaction Map	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 101 to 150 of 3730 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Interaction Map  : High confidence

Rank	Hugo	Filtered	description	red	green	network_comparison
51	KPNA2	0	importin alpha-2 subunit (karyopherin alpha-2 subunit) (srp1-alpha) (rag cohort protein 1). [swissprot;acc:p52292]	7168	5102	1.40494
	SPATA6	1	spermatogenesis associated 6. [refseq;acc:nm_019073]	133	105	1.26667
52	AMPD2		amp deaminase 2 (ec 3.5.4.6) (amp deaminase isoform l). [swissprot;acc:q01433]
	ARIH2	0	ariadne-2 protein homolog (ari-2) (triad1 protein) (ht005). [swissprot;acc:o95376]	3284	4554.5	1.38688
53	no value		ubiquitin-conjugating enzyme e2-18 kda ubch7 (ec 6.3.2.19) (ubiquitin- protein ligase) (ubiquitin carrier protein) (ubcm4) (e2-f1) (l-ubc). [swissprot;acc:p51966]
	JUNB	1	transcription factor jun-b. [swissprot;acc:p17275]	201.144	158.868	1.26611
54	JUND		transcription factor jun-d. [swissprot;acc:p17535]	200.941	158.941	1.26425
	STX10	0	syntaxin 10 (syn10). [swissprot;acc:o60499]	13884.4	19014.6	1.36949
55	PRKRAP1	1	protein kinase, interferon-inducible double stranded rna dependent activator; protein activator of the interferon-induced protein kinase. [refseq;acc:nm_003690]	320.927	254.434	1.26134
	ZNF547	0	sedlin. [swissprot;acc:o14582]	22440	16388	1.36929
56	no value		synbindin (trs23 homolog) (hematopoietic stem/progenitor cell protein 172) (hspc172) (ptd009) (cgi-104). [swissprot;acc:q9y296]
		1	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-7 subunit. [swissprot;acc:o60262]	266.856	336.233	1.25998
57	CDC37	0	hsp90 co-chaperone cdc37 (hsp90 chaperone protein kinase-targeting subunit) (p50cdc37). [swissprot;acc:q16543]	8152.55	11134.8	1.36581
	GNG12	1	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-12 subunit. [swissprot;acc:q9ubi6]	266.856	336.233	1.25998
58	DDX43	0	dead-box protein. [refseq;acc:nm_018665]	10628.3	14486	1.36296
	GNG4	1	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-4 subunit. [swissprot;acc:p50150]	266.863	336.191	1.25979
59	GLUD2	0	glutamate dehydrogenase 2, mitochondrial precursor (ec 1.4.1.3) (gdh). [swissprot;acc:p49448]	15863.6	11662.3	1.36025
	GNG3	1	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-3 subunit. [swissprot;acc:p29798]	266.863	336.19	1.25978
60	GNG8		guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-8 subunit (gamma-9). [swissprot;acc:q9uk08]	266.864	336.184	1.25976
	GNPDA1	0	glucosamine-6-phosphate isomerase (ec 3.5.99.6) (glucosamine-6- phosphate deaminase) (gnpda) (glcn6p deaminase) (oscillin). [swissprot;acc:p46926]	11761	15924	1.35397
61	CRISP2		testis-specific protein tpx-1 precursor (cysteine-rich secretory protein-2) (crisp-2). [swissprot;acc:p16562]	15352	11346.5	1.35302
	GNG5	1	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 subunit. [swissprot;acc:p30670]	266.864	336.182	1.25975
62	GLRA3	0	glycine receptor alpha-3 chain precursor. [swissprot;acc:o75311]	9418.7	12695.6	1.34791
	GNG10	1	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-10 subunit. [swissprot;acc:p50151]	266.865	336.181	1.25974
63	no value		guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 like subunit. [swissprot;acc:q9y3k8]		336.178	1.25973
	STT3A	0	oligosaccharyl transferase stt3 subunit homolog (b5) (integral membrane protein 1) (tmc). [swissprot;acc:p46977]	8519.83	11453	1.34428
64	GNG11	1	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-11 subunit. [swissprot;acc:p50152]	266.868	336.159	1.25965
	LYZL1	0	similar to lysozyme c-1 (1,4-beta-n-acylmuramidase c, ec 3.2.1.17). [refseq;acc:nm_032517]	15264	20387	1.33563
65	EP400		e1a binding protein p400; p400 swi2/snf2-related protein; cagh32 protein; trinucleotide repeat containing 12. [refseq;acc:nm_015409]	7853.67	10406.3	1.32502
	GNAQ	1	guanine nucleotide-binding protein g(q), alpha subunit. [swissprot;acc:p50148]	267.136	336.077	1.25807
66	GNA11		guanine nucleotide-binding protein g(y), alpha subunit (alpha-11). [swissprot;acc:p29992]
	HS6ST2	0	heparan sulfate 6-o-sulfotransferase 2. [refseq;acc:nm_147174]	11461	15180	1.32449
67	no value		presenilin enhancer 2; hematopoietic stem/progenitor cells protein mds033. [refseq;acc:nm_172341]	10793.5	14291.5	1.32408
	GNAT2	1	guanine nucleotide-binding protein g(t), alpha-2 subunit (transducin alpha-2 chain). [swissprot;acc:p19087]	267.14	336.075	1.25805
68	no value	0	purine nucleoside phosphorylase (ec 2.4.2.1) (inosine phosphorylase) (pnp). [swissprot;acc:p00491]	8932.56	11823.3	1.32362
	GNAZ	1	guanine nucleotide-binding protein g(z), alpha subunit (g(x) alpha chain) (gz-alpha). [swissprot;acc:p19086]	267.139	336.075	1.25805
69	no value	0	collagen alpha 5(iv) chain precursor. [swissprot;acc:p29400]	7704.7	10174.1	1.32051
	GNAT1	1	guanine nucleotide-binding protein g(t), alpha-1 subunit (transducin alpha-1 chain). [swissprot;acc:p11488]	267.14	336.075	1.25805
70	no value	0	protein regulator of cytokinesis 1; protein regulating cytokinesis 1. [refseq;acc:nm_003981]	13975.7	10593.2	1.31931
	GNAI2	1	guanine nucleotide-binding protein g(i), alpha-2 subunit (adenylate cyclase-inhibiting g alpha protein). [swissprot;acc:p04899]	267.142	336.074	1.25804
71	GNAI1		guanine nucleotide-binding protein g(i), alpha-1 subunit (adenylate cyclase-inhibiting g alpha protein). [swissprot;acc:p04898]	267.144	336.073	1.25802
	NUP43	0	nucleoporin nup43 (p42). [swissprot;acc:q8nfh3]	4338.65	5700.79	1.31395
72	GNAI3	1	guanine nucleotide-binding protein g(k), alpha subunit (g(i) alpha-3). [swissprot;acc:p08754]	267.144	336.073	1.25802
	PGAM4	0	putative phosphoglycerate mutase 3 (ec 5.4.2.1) (ec 5.4.2.4) (ec 3.1.3.13). [swissprot;acc:q8n0y7]	4119	5397	1.31027
73	no value		phosphoglycerate mutase 1 (ec 5.4.2.1) (ec 5.4.2.4) (ec 3.1.3.13) (phosphoglycerate mutase isozyme b) (pgam-b) (bpg-dependent pgam 1). [swissprot;acc:p18669]
	JPH3	1	junctophilin 3 (junctophilin type 3) (jp-3). [swissprot;acc:q8wxh2]	288	362	1.25694
74	no value	0	ataxin 2; olivopontocerebellar ataxia 2, autosomal dominant. [refseq;acc:nm_002973]	6742.5	8759.5	1.29915
	JPH2	1	junctophilin 2 (junctophilin type 2) (jp-2). [swissprot;acc:q9br39]	288	362	1.25694
75	no value	0	nanos (fragment). [sptrembl;acc:q8wy41]	8782	11350	1.29242
	SMPD2	1	sphingomyelin phosphodiesterase 2 (ec 3.1.4.12) (neutral sphingomyelinase) (nsmase) (n-smase) (lyso-platelet activating factor- phospholipase c) (lyso-paf-plc). [swissprot;acc:o60906]	288	362	1.25694

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.