MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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green	Gene	description	red	Hugo	Rank	Value Type	Network Comparison Type	network_comparison	Interaction Map	Filtered

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Showing element 1 to 50 of 3228 in total

green  : 0.00001
red  : 0.00001
Value Type  : Ranked
Network Comparison Type  : Divided
network_comparison  : 1
Interaction Map  : High confidence
Filtered  : 1

description	Hugo	Rank
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 (ec 3.1.4.11) (phosphoinositide phospholipase c) (plc-beta-4) (phospholipase c-beta-4). [swissprot;acc:q15147]	PLCB4	3126
10-formyltetrahydrofolate dehydrogenase (ec 1.5.1.6) (10-fthfdh). [swissprot;acc:o75891]	ALDH1L1	2922
14-3-3 protein epsilon (mitochondrial import stimulation factor l subunit) (protein kinase c inhibitor protein-1) (kcip-1) (14-3-3e). [swissprot;acc:p42655]	YWHAE	3088
15-hydroxyprostaglandin dehydrogenase [nad(+)] (ec 1.1.1.141) (pgdh). [swissprot;acc:p15428]	HPGD	2855
25-hydroxyvitamin d-1 alpha hydroxylase, mitochondrial precursor (ec 1.14.-.-) (25-ohd-1 alpha-hydroxylase) (25-hydroxyvitamin d3 1- alpha-hydroxylase) (vd3 1a hydroxylase) (p450c1 alpha) (p450vd1- alpha). [swissprot;acc:o15528]	CYP27B1	3079
3 beta-hydroxy-delta 5-c27-steroid oxidoreductase. [refseq;acc:nm_025193]	HSD3B7	3147
3 beta-hydroxysteroid dehydrogenase (fragments). [sptrembl;acc:q9udk8]	no value	2756
3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase type i (3beta-hsd i) (trophoblast antigen fdo161g) [includes: 3-beta-hydroxy- delta(5)-steroid dehydrogenase (ec 1.1.1.145) (3-beta-hydroxy-5-ene steroid dehydrogenase) (progesterone reductase); steroid delta- isomerase (ec 5.3.3.1) (delta-5-3-ketosteroid isomerase)]. [swissprot;acc:p14060]		2802
3-hydroxyacyl-coa dehydrogenase type ii (ec 1.1.1.35) (type ii hadh) (endoplasmic reticulum-associated amyloid beta-peptide binding protein) (short-chain type dehydrogenase/reductase xh98g2). [swissprot;acc:q99714]	HSD17B10	3180
6-pyruvoyl tetrahydrobiopterin synthase (ec 4.2.3.12) (ptps) (ptp synthase). [swissprot;acc:q03393]	PTS	2904
60s ribosomal protein l37a. [swissprot;acc:p12751]	no value	2959
69 kda islet cell autoantigen (ica69) (islet cell autoantigen 1) (islet cell autoantigen p69) (icap69). [swissprot;acc:q05084]	ICA1	3227
a-kinase anchor protein 5 (a-kinase anchor protein 79 kda) (akap 79) (camp-dependent protein kinase regulatory subunit ii high affinity binding protein) (h21). [swissprot;acc:p24588]	AKAP5	2788
activin receptor type i precursor (ec 2.7.1.37) (actr-i) (serine/threonine-protein kinase receptor r1) (skr1) (activin receptor-like kinase 2) (alk-2) (tgf-b superfamily receptor type i) (tsr-i). [swissprot;acc:q04771]	ACVR1	3050
adaptor protein with pleckstrin homology and src homology 2 domains. [refseq;acc:nm_020979]	SH2B2	2870
aldehyde dehydrogenase 7 (ec 1.2.1.5). [swissprot;acc:p43353]	ALDH3B1	3222
aldehyde dehydrogenase 8 (ec 1.2.1.5). [swissprot;acc:p48448]	ALDH3B2	2992
aldehyde oxidase (ec 1.2.3.1). [swissprot;acc:q06278]	AOX1	2960
alpha crystallin a chain. [swissprot;acc:p02489]	CRYAA	2875
alpha crystallin b chain (alpha(b)-crystallin) (rosenthal fiber component). [swissprot;acc:p02511]	CRYAB	3082
alveolar soft part sarcoma chromosome region, candidate 1; aspl protein; renal cell carcinoma gene on chromosome 17; renal cell carcinoma, papillary, 17 gene; aspscr1/tfe3 fusion gene, included. [refseq;acc:nm_024083]	ASPSCR1	2829
amyloid beta precursor protein-binding protein 2; amyloid beta precursor protein (cytoplasmic tail)-binding protein 2; protein interacting with app tail 1. [refseq;acc:nm_006380]	APPBP2	3191
ariadne-2 protein homolog (ari-2) (triad1 protein) (ht005). [swissprot;acc:o95376]	ARIH2	2798
atp synthase coupling factor 6, mitochondrial precursor (ec 3.6.3.14) (f6). [swissprot;acc:p18859]	ATP5J	2893
atp synthase g chain, mitochondrial (ec 3.6.3.14) (atpase subunit g). [swissprot;acc:o75964]	ATP5L	2834
au rna-binding protein/enoyl-coenzyme a hydratase precursor; au rna-binding protein/enoyl-coenzyme a hydratase; 3-methylglutaconyl-coa hydratase; mga type i. [refseq;acc:nm_001698]	AUH	2913
ba203i16.1 (hypothetical protein kiaa0970). [sptrembl;acc:q9h1w1]	FNDC3A	3117
ba528a10.3.2 (novel protein similar to kiaa0161, isoform 2) (fragment). [sptrembl;acc:q9bx39]	RNF144B	2968
barrier-to-autointegration factor (breakpoint cluster region protein 1). [swissprot;acc:o75531]	BANF1	2804
bax inhibitor-1 (bi-1) (testis enhanced gene transcript). [swissprot;acc:p55061]	TEGT	2950
bcl-6 interacting corepressor isoform 1. [refseq;acc:nm_017745]	BCOR	2776
beta-ureidopropionase (ec 3.5.1.6) (beta-alanine synthase) (n-carbamoyl-beta-alanine amidohydrolase) (bup-1). [swissprot;acc:q9ubr1]	UPB1	3145
bone morphogenetic protein 5 precursor (bmp-5). [swissprot;acc:p22003]	BMP5	3069
bone morphogenetic protein 6 precursor (bmp-6). [swissprot;acc:p22004]	BMP6	2896
bone morphogenetic protein 7 precursor (bmp-7) (osteogenic protein 1) (op-1). [swissprot;acc:p18075]	BMP7	3128
bone morphogenetic protein 8 precursor (bmp-8) (osteogenic protein 2) (op-2). [swissprot;acc:p34820]	BMP8A	2773
brca1 associated protein. [refseq;acc:nm_006768]	BRAP	3161
bromodomain and phd finger-containing protein 3 (fragment). [swissprot;acc:q9uld4]	BRPF3	3149
bromodomain-containing protein 1 (br140-like protein). [swissprot;acc:o95696]	BRD1	3139
bs4 protein (ny-ren-18 antigen). [swissprot;acc:q9y5a7]	NUB1	3214
bup protein. [refseq;acc:nm_012071]	COMMD3	2911
calmodulin. [swissprot;acc:p02593]	no value	2928
camp responsive element binding protein-like 2. [refseq;acc:nm_001310]	CREBL2	3078
camp-dependent protein kinase type i-alpha regulatory chain (tissue- specific extinguisher-1) (tse1). [swissprot;acc:p10644]	PRKAR1A	3089
carcinoma related gene. [refseq;acc:nm_016041]	DERL2	3179
carnitine o-palmitoyltransferase ii, mitochondrial precursor (ec 2.3.1.21) (cpt ii). [swissprot;acc:p23786]	CPT2	2885
casein kinase i, gamma 1 isoform (ec 2.7.1.-) (cki-gamma 1). [swissprot;acc:q9hcp0]	CSNK1G1	2830
casein kinase i, gamma 2 isoform (ec 2.7.1.-) (cki-gamma 2). [swissprot;acc:p78368]	CSNK1G2	2986
casein kinase i, gamma 3 isoform (ec 2.7.1.-) (cki-gamma 3). [swissprot;acc:q9y6m4]	CSNK1G3	2901
caveolin-1. [swissprot;acc:q03135]	CAV1	3099

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.