MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	Network Comparison Type	Value Type	description	Interaction Map	Filtered	network_comparison	red	green

Results: HTML CSV LaTeX

Showing element 1 to 50 of 33156 in total

Network Comparison Type  : Divided
Filtered  : 1

Rank	Hugo	Value Type	description	Interaction Map	network_comparison	red	green
1	CPD	Ranked	carboxypeptidase d precursor (ec 3.4.17.-) (gp180). [swissprot;acc:o75976]	Low confidence	2	16	32
	LAMP1	Measured	lysosome-associated membrane glycoprotein 1 precursor (lamp-1) (cd107a antigen). [swissprot;acc:p11279]		4.4149	2399.5	543.5
		Squared			19.4914	1362.75	69.9153
		Rooted			2.10117	48.9847	23.3131
	RINT1	Measured	rad50-interacting protein 1. [refseq;acc:nm_021930]	High confidence	5.31521	450.5	2394.5
		Squared			28.2513	48.0356	1357.07
		Rooted			2.30547	21.225	48.9336
	UBAC1	Ranked	putative glialblastoma cell differentiation-related; putative glialblastoma cell differentiation-related protein. [refseq;acc:nm_016172]		2.4	10	24
2	no value		mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476]		1.86667	15	28
	CDK4	Measured	cell division protein kinase 4 (ec 2.7.1.37) (cyclin-dependent kinase 4) (psk-j3). [swissprot;acc:p11802]	Low confidence	4.4149	2399.5	543.5
		Squared			19.4914	1362.75	69.9153
		Rooted			2.10117	48.9847	23.3131
	LAMP1	Ranked	lysosome-associated membrane glycoprotein 1 precursor (lamp-1) (cd107a antigen). [swissprot;acc:p11279]		1.47982	223	330
	RHOBTB2	Measured	rho-related btb domain-containing protein 2 (deleted in breast cancer 2 gene protein) (p83). [swissprot;acc:q9byz6]	High confidence	5.31521	450.5	2394.5
		Squared			28.2513	48.0356	1357.07
		Rooted			2.30547	21.225	48.9336
3	CDK4	Ranked	cell division protein kinase 4 (ec 2.7.1.37) (cyclin-dependent kinase 4) (psk-j3). [swissprot;acc:p11802]	Low confidence	1.47982	223	330
	CDK6	Measured	cell division protein kinase 6 (ec 2.7.1.37) (serine/threonine protein kinase plstire). [swissprot;acc:q00534]		4.4149	2399.5	543.5
		Squared			19.4914	1362.75	69.9153
		Rooted			2.10117	48.9847	23.3131
	HLX	Measured	homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774]	High confidence	3.71868	2597.5	698.5
		Squared			13.8285	1596.92	115.48
		Rooted			1.92839	50.9657	26.4292
	PSCD1	Ranked	cytohesin 1 (sec7 homolog b2-1). [swissprot;acc:q15438]		1.86667	15	28
4	CDK6		cell division protein kinase 6 (ec 2.7.1.37) (serine/threonine protein kinase plstire). [swissprot;acc:q00534]	Low confidence	1.47982	223	330
	HBS1L	Measured	hbs1-like. [refseq;acc:nm_006620]	High confidence	3.71868	2597.5	698.5
		Squared			13.8285	1596.92	115.48
		Rooted			1.92839	50.9657	26.4292
	LAMP2	Measured	lysosome-associated membrane glycoprotein 2 precursor (lamp-2) (cd107b antigen). [swissprot;acc:p13473]	Low confidence	4.4149	2399.5	543.5
		Squared			19.4914	1362.75	69.9153
		Rooted			2.10117	48.9847	23.3131
	PSCD2	Ranked	cytohesin 2 (arf nucleotide-binding site opener) (arno protein) (arf exchange factor). [swissprot;acc:q99418]	High confidence	1.86667	15	28
5	JPH3	Measured	junctophilin 3 (junctophilin type 3) (jp-3). [swissprot;acc:q8wxh2]		3.39764	1153.5	339.5
		Squared			11.544	314.926	27.2805
		Rooted			1.84327	33.9632	18.4255
	LAMP2	Ranked	lysosome-associated membrane glycoprotein 2 precursor (lamp-2) (cd107b antigen). [swissprot;acc:p13473]	Low confidence	1.47982	223	330
	OSBPL6	Measured	oxysterol binding protein-related protein 6 (osbp-related protein 6) (orp-6). [swissprot;acc:q9bzf3]		2.86965	736.5	2113.5
		Squared			8.23493	128.386	1057.25
		Rooted			1.69401	27.1385	45.9728
	PSCD4	Ranked	cytohesin 4. [swissprot;acc:q9uia0]	High confidence	1.86667	15	28
6	JPH2	Measured	junctophilin 2 (junctophilin type 2) (jp-2). [swissprot;acc:q9br39]		3.39764	1153.5	339.5
		Squared			11.544	314.926	27.2805
		Rooted			1.84327	33.9632	18.4255
	OSBPL3	Measured	oxysterol binding protein-related protein 3 (osbp-related protein 3) (orp-3). [swissprot;acc:q9h4l5]	Low confidence	2.86965	736.5	2113.5
		Squared			8.23493	128.386	1057.25
		Rooted			1.69401	27.1385	45.9728
	OSBPL6	Ranked	oxysterol binding protein-related protein 6 (osbp-related protein 6) (orp-6). [swissprot;acc:q9bzf3]		1.325	318	240
	PSCD3		cytohesin 3 (arf nucleotide-binding site opener 3) (arno3 protein) (general receptor of phosphoinositides 1) (grp1). [swissprot;acc:o43739]	High confidence	1.86667	15	28
7	HLX		homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774]		1.49767	215	322
	OSBPL3		oxysterol binding protein-related protein 3 (osbp-related protein 3) (orp-3). [swissprot;acc:q9h4l5]	Low confidence	1.325	318	240

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.