MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 2425 to 2474 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	Hugo	description	Network Comparison Type	red	green	network_comparison
1213	COG2	conserved oligomeric golgi complex component 2 (low density lipoprotein receptor defect c-complementing protein). [swissprot;acc:q14746]	Divided	214.364	219.759	1.02517
	COPZ1	coatomer zeta-1 subunit (zeta-1 coat protein) (zeta-1 cop) (cgi-120) (hspc181). [swissprot;acc:q9y3c3]	Subtracted	174.387	179.697	5.31
1214	no value	kinesin-like protein kif13b (kinesin-like protein gakin). [swissprot;acc:q9nqt8]	Divided	214.364	219.759	1.02517
	ARCN1	coatomer delta subunit (delta-coat protein) (delta-cop) (archain). [swissprot;acc:p48444]	Subtracted	174.387	179.697	5.31
1215	DAZAP1	daz associated protein 1 isoform b; deleted in azoospermia associated protein 1. [refseq;acc:nm_018959]	Divided	218.268	212.916	1.02514
	PPIE	peptidyl-prolyl cis-trans isomerase e (ec 5.2.1.8) (ppiase e) (rotamase e) (cyclophilin e) (cyclophilin 33). [swissprot;acc:q9unp9]	Subtracted	174.387	179.697	5.31
1216	COPZ2	coatomer zeta-2 subunit (zeta-2 coat protein) (zeta-2 cop). [swissprot;acc:q9p299]
	ZMIZ1	retinoic acid induced 17; pias-like protein hzimp10. [refseq;acc:nm_020338]	Divided	218.269	212.918	1.02513
1217	HAS2	hyaluronan synthase 2 (ec 2.4.1.212) (hyaluronate synthase 2) (hyaluronic acid synthase 2) (ha synthase 2). [swissprot;acc:q92819]	Subtracted	221.093	226.399	5.306
	QRSL1	glutaminyl-trna synthase (glutamine-hydrolyzing)-like 1. [refseq;acc:nm_018292]	Divided	211.959	217.258	1.025
1218	FAAH	fatty-acid amide hydrolase (ec 3.1.-.-) (oleamide hydrolase) (anandamide amidohydrolase). [swissprot;acc:o00519]
	HAS1	hyaluronan synthase 1 (ec 2.4.1.212) (hyaluronate synthase 1) (hyaluronic acid synthase 1) (ha synthase 1) (huhas1). [swissprot;acc:q92839]	Subtracted	221.093	226.399	5.306
1219	COTL1	coactosin-like protein. [swissprot;acc:q14019]	Divided	211.959	217.258	1.025
	HAS3	hyaluronan synthase 3 (ec 2.4.1.212) (hyaluronate synthase 3) (hyaluronic acid synthase 3) (ha synthase 3). [swissprot;acc:o00219]	Subtracted	221.093	226.399	5.306
1220	QRSL1	glutaminyl-trna synthase (glutamine-hydrolyzing)-like 1. [refseq;acc:nm_018292]		211.959	217.258	5.299
	UNG	uracil-dna glycosylase, mitochondrial precursor (ec 3.2.2.-) (udg). [swissprot;acc:p13051]	Divided			1.025
1221	FAAH	fatty-acid amide hydrolase (ec 3.1.-.-) (oleamide hydrolase) (anandamide amidohydrolase). [swissprot;acc:o00519]	Subtracted			5.299
	PET112L	probable glutamyl-trna(gln) amidotransferase subunit b, mitochondrial precursor (ec 6.3.5.-) (glu-adt subunit b) (cytochrome oxidase assembly factor pet112 homolog). [swissprot;acc:o75879]	Divided			1.025
1222	COTL1	coactosin-like protein. [swissprot;acc:q14019]	Subtracted			5.299
	TPD52L1	tumor protein d53 (hd53) (d52-like 1). [swissprot;acc:q16890]	Divided	206.774	211.936	1.02496
1223	TPD52	tumor protein d52 (n8 protein). [swissprot;acc:p55327]		206.771	211.926	1.02493
	UNG	uracil-dna glycosylase, mitochondrial precursor (ec 3.2.2.-) (udg). [swissprot;acc:p13051]	Subtracted	211.959	217.258	5.299
1224	FPGS	folylpolyglutamate synthase, mitochondrial precursor (ec 6.3.2.17) (folylpoly-gamma-glutamate synthetase) (fpgs). [swissprot;acc:q05932]	Divided	225.906	231.524	1.02487
	PET112L	probable glutamyl-trna(gln) amidotransferase subunit b, mitochondrial precursor (ec 6.3.5.-) (glu-adt subunit b) (cytochrome oxidase assembly factor pet112 homolog). [swissprot;acc:o75879]	Subtracted	211.959	217.258	5.299
1225	IL4I1	interleukin-4 induced protein 1 precursor (fig-1 protein). [swissprot;acc:q96rq9]		219.55	214.288	5.262
	UBE2E1	ubiquitin-conjugating enzyme e2 e1 (ec 6.3.2.19) (ubiquitin-protein ligase e1) (ubiquitin carrier protein e1) (ubch6). [swissprot;acc:p51965]	Divided	166.846	170.989	1.02483
1226	FDX1	adrenodoxin, mitochondrial precursor (adrenal ferredoxin) (hepatoredoxin) (ferredoxin 1). [swissprot;acc:p10109]	Subtracted	191.139	185.882	5.257
	UBE2E4P	ubiquitin-conjugating enzyme e2e 3; ubiquitin carrier protein; ubiquitin-protein ligase. [refseq;acc:nm_006357]	Divided	166.846	170.989	1.02483
1227	GCLM	glutamate--cysteine ligase regulatory subunit (ec 6.3.2.2) (gamma- glutamylcysteine synthetase) (gamma-ecs) (gcs light chain) (glutamate--cysteine ligase modifier subunit). [swissprot;acc:p48507]	Subtracted	213.079	218.325	5.246
	PYCR2	pyrroline 5-carboxylate reductase isoform. [refseq;acc:nm_013328]	Divided	172.365	168.219	1.02465
1228	GCLC	glutamate--cysteine ligase catalytic subunit (ec 6.3.2.2) (gamma- glutamylcysteine synthetase) (gamma-ecs) (gcs heavy chain). [swissprot;acc:p48506]	Subtracted	213.079	218.325	5.246
	GCLM	glutamate--cysteine ligase regulatory subunit (ec 6.3.2.2) (gamma- glutamylcysteine synthetase) (gamma-ecs) (gcs light chain) (glutamate--cysteine ligase modifier subunit). [swissprot;acc:p48507]	Divided			1.02462
1229	no value	integral membrane protein cii-3b. [sptrembl;acc:o75609]	Subtracted	207.646	212.891	5.245
	GCLC	glutamate--cysteine ligase catalytic subunit (ec 6.3.2.2) (gamma- glutamylcysteine synthetase) (gamma-ecs) (gcs heavy chain). [swissprot;acc:p48506]	Divided	213.079	218.325	1.02462
1230	IL4I1	interleukin-4 induced protein 1 precursor (fig-1 protein). [swissprot;acc:q96rq9]		219.55	214.288	1.02456
	SDHC	succinate dehydrogenase cytochrome b560 subunit, mitochondrial precursor (integral membrane protein cii-3) (qps1) (qps-1) (succinate dehydrogenase complex subunit c) (succinate-ubiquinone oxidoreductase cytochrome b large subunit) (cybl). [swissprot;acc:q99643]	Subtracted	207.644	212.888	5.244
1231	PGAM4	putative phosphoglycerate mutase 3 (ec 5.4.2.1) (ec 5.4.2.4) (ec 3.1.3.13). [swissprot;acc:q8n0y7]	Divided	212.724	207.637	1.0245
	SDHB	succinate dehydrogenase [ubiquinone] iron-sulfur protein, mitochondrial precursor (ec 1.3.5.1) (ip) (iron-sulfur subunit of complex ii). [swissprot;acc:p21912]	Subtracted	207.931	213.175	5.244
1232	no value	alpha-1-acid glycoprotein 2 precursor (agp 2) (orosomucoid 2) (omd 2). [swissprot;acc:p19652]		209.649	204.406	5.243
	PYCR1	pyrroline-5-carboxylate reductase (ec 1.5.1.2) (p5cr) (p5c reductase). [swissprot;acc:p32322]	Divided	172.543	168.417	1.0245
1233	no value	phosphoglycerate mutase 1 (ec 5.4.2.1) (ec 5.4.2.4) (ec 3.1.3.13) (phosphoglycerate mutase isozyme b) (pgam-b) (bpg-dependent pgam 1). [swissprot;acc:p18669]		212.724	207.637
	SEPT1	septin 1 (larp) (serologically defined breast cancer antigen ny-br- 24). [swissprot;acc:q8wyj6]	Subtracted	142.077	136.846	5.231
1234	PGAM2	phosphoglycerate mutase 2 (ec 5.4.2.1) (ec 5.4.2.4) (ec 3.1.3.13) (phosphoglycerate mutase isozyme m) (pgam-m) (bpg-dependent pgam 2) (muscle-specific phosphoglycerate mutase). [swissprot;acc:p15259]	Divided	212.724	207.637	1.0245
	UBB	ubiquitin. [swissprot;acc:p02248]	Subtracted	209.6	204.372	5.228
1235	no value	keratin associated protein 9-4; keratin associated protein 9.4. [refseq;acc:nm_033191]	Divided	219.356	224.723	1.02447
	COPA	coatomer alpha subunit (alpha-coat protein) (alpha-cop) (hepcop) (hep-cop) [contains: xenin (xenopsin-related peptide); proxenin]. [swissprot;acc:p53621]	Subtracted	177.432	182.647	5.215
1236	no value	keratin associated protein 4-10; keratin associated protein 4.10. [refseq;acc:nm_033060]	Divided	219.354	224.699	1.02437
	VBP1	prefoldin subunit 3 (von hippel-lindau binding protein 1) (vhl binding protein-1) (vbp-1) (hibbj46). [swissprot;acc:q15765]	Subtracted	226.439	221.26	5.179
1237	no value	keratin associated protein 4-2; keratin associated protein 4.2. [refseq;acc:nm_033062]	Divided	219.354	224.699	1.02437
	PFDN2	prefoldin subunit 2 (hspc231). [swissprot;acc:q9uhv9]	Subtracted	226.439	221.26	5.179

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.