MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1982 to 2031 of 12912 in total

Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Value Type	red	green	network_comparison
496	nostrin. [refseq;acc:nm_052946]	Measured	4682.87	4093.05	1.1441
	suppressor of swi4 1 homolog (ssf-1) (peter pan homolog). [swissprot;acc:q9nq55]	Ranked	250.938	234.134	1.07177
	tubby protein homolog. [swissprot;acc:p50607]	Squared	30286.5	36362	1.2006
497	eap30 subunit of ell complex. [refseq;acc:nm_007241]	Measured	4682.87	4093.05	1.1441
	probable rrna processing protein ebp2 (ebna1 binding protein 2) (nucleolar protein p40). [swissprot;acc:q99848]	Ranked	251.344	234.514	1.07177
	protein kinase c, iota type (ec 2.7.1.37) (npkc-iota) (atypical protein kinase c-lamda/iota) (apkc-lambda/iota). [swissprot;acc:p41743]	Squared	30286.5	36362	1.2006
	pwwp domain containing 1; hdgf (hepatoma-derived growth factor) like. [refseq;acc:nm_138574]	Rooted	55.1759	60.2621	1.09218
498	liv-1 protein, estrogen regulated. [refseq;acc:nm_012319]	Measured	4682.87	4093.05	1.1441
	numb protein homolog (h-numb) (protein s171). [swissprot;acc:p49757]	Squared	30286.5	36362	1.2006
	probable atp-dependent rna helicase p54 (oncogene rck) (dead-box protein 6). [swissprot;acc:p26196]	Rooted	55.1759	60.2621	1.09218
	rho guanine nucleotide exchange factor 6 (pak-interacting exchange factor alpha) (alpha-pix) (cool-2). [swissprot;acc:q15052]	Ranked	220.161	235.95	1.07172
499	glutamate decarboxylase, 65 kda isoform (ec 4.1.1.15) (gad-65) (65 kda glutamic acid decarboxylase). [swissprot;acc:q05329]	Measured	4682.87	4093.05	1.1441
	rw1 protein (fragment). [swissprot;acc:q92545]	Rooted	55.1759	60.2621	1.09218
	tbc1 domain family member 5. [swissprot;acc:q92609]	Squared	30286.5	36362	1.2006
	triosephosphate isomerase (ec 5.3.1.1) (tim). [swissprot;acc:p00938]	Ranked	231.496	248.048	1.0715
500	60s ribosomal protein l7. [swissprot;acc:p18124]	Rooted	52.6483	48.2135	1.09198
	gamma-soluble nsf attachment protein (snap-gamma) (n-ethylmaleimide- sensitive factor attachment protein, gamma). [swissprot;acc:q99747]	Measured	4682.87	4093.05	1.1441
	inhibitor of growth family, member 1-like; inhibitor of growth 1-like. [refseq;acc:nm_001564]	Ranked	224.662	240.673	1.07127
	tubby related protein 1 (tubby-like protein 1). [swissprot;acc:o00294]	Squared	30286.5	36362	1.2006
501	cytochrome c1, heme protein, mitochondrial precursor (cytochrome c-1). [swissprot;acc:p08574]	Ranked	238.704	255.68	1.07112
	dna-directed rna polymerase i largest subunit (ec 2.7.7.6) (rna polymerase i 194 kda subunit) (rpa194). [swissprot;acc:o95602]	Rooted	50.4253	46.1792	1.09195
	glutamate decarboxylase, 67 kda isoform (ec 4.1.1.15) (gad-67) (67 kda glutamic acid decarboxylase). [swissprot;acc:q99259]	Measured	4682.87	4093.05	1.1441
	vacuolar protein sorting 29 (vesicle protein sorting 29) (hvps29) (mds007) (pep11) (dc7/dc15). [swissprot;acc:q9ubq0]	Squared	30286.5	36362	1.2006
502	60s ribosomal protein l30. [swissprot;acc:p04645]	Rooted	50.4616	46.2257	1.09164
	numb-like protein (numb-r). [swissprot;acc:q9y6r0]	Squared	30286.5	36362	1.2006
	oligophrenin-1 like protein (gtpase regulator associated with focal adhesion kinase). [swissprot;acc:q9una1]	Ranked	238.704	255.68	1.07112
	ribonucleoside-diphosphate reductase m1 chain (ec 1.17.4.1) (ribonucleotide reductase large chain). [swissprot;acc:p23921]	Measured	6913.6	7907.05	1.1437
503	nuclear dna-binding protein; small unique nuclear receptor corepressor; c1d dna-binding protein. [refseq;acc:nm_006333]	Rooted	177.987	194.29	1.0916
	senescence marker protein-30 (smp-30) (regucalcin) (rc). [swissprot;acc:q15493]	Ranked	238.704	255.68	1.07112
	tubby related protein 3 (tubby-like protein 3). [swissprot;acc:o75386]	Squared	30286.5	36362	1.2006
	tumor suppressor p53-binding protein 2 (p53-binding protein 2) (53bp2) (bcl2-binding protein) (bbp). [swissprot;acc:q13625]	Measured	15182.5	13277.9	1.14344
504	enoyl-coa hydratase, mitochondrial precursor (ec 4.2.1.17) (short chain enoyl-coa hydratase) (sceh) (enoyl-coa hydratase 1). [swissprot;acc:p30084]		10067.9	11511	1.14334
	oligophrenin 1. [swissprot;acc:o60890]	Ranked	238.704	255.68	1.07112
	ras-related gtp binding a; ras-related gtp-binding protein. [refseq;acc:nm_006570]	Rooted	144.606	157.824	1.09141
	vacuolar protein sorting 35 (vesicle protein sorting 35) (hvps35) (maternal-embryonic 3). [swissprot;acc:q96qk1]	Squared	30286.5	36362	1.2006
505	ad24 protein. [refseq;acc:nm_022451]	Ranked	251.334	234.672	1.071
	protein kinase c, zeta type (ec 2.7.1.37) (npkc-zeta). [swissprot;acc:q05513]	Squared	30286.5	36362	1.2006
	ras-related gtp binding c; rag c protein. [refseq;acc:nm_022157]	Rooted	144.606	157.824	1.09141
	signal transduction protein cbl-b (sh3-binding protein cbl-b). [swissprot;acc:q13191]	Measured	6856.71	7838.3	1.14316
506	eukaryotic translation initiation factor 6 (eif-6) (b4 integrin interactor) (cab) (p27(bbp)) (b(2)gcn homolog). [swissprot;acc:p56537]		3893.85	4450.98	1.14308
	inhibitor of growth family, member 1; inhibitor of growth 1. [refseq;acc:nm_005537]	Ranked	224.535	240.476	1.071
	ras-related gtp binding b short isoform; gtp-binding protein ragb. [refseq;acc:nm_006064]	Rooted	144.606	157.824	1.09141
	vav-2 protein. [swissprot;acc:p52735]	Squared	31377.3	37670.1	1.20055
507	anillin, actin binding protein (scraps homolog, drosophila); anillin (drosophila scraps homolog), actin binding protein. [refseq;acc:nm_018685]	Rooted	144.606	157.824	1.09141
	cbl e3 ubiquitin protein ligase (ec 6.3.2.-) (signal transduction protein cbl) (proto-oncogene c-cbl). [swissprot;acc:p22681]	Measured	6875.08	7858.38	1.14302
	puromycin-sensitive aminopeptidase (ec 3.4.11.-) (psa). [swissprot;acc:p55786]	Squared	23512.2	28206.2	1.19964
	wd-repeat protein 12 (ytm1 homolog). [swissprot;acc:q9gzl7]	Ranked	251.299	234.729	1.07059
508	1-acyl-sn-glycerol-3-phosphate acyltransferase beta (ec 2.3.1.51) (1- agp acyltransferase 2) (1-agpat 2) (lysophosphatidic acid acyltransferase-beta) (lpaat-beta) (1-acylglycerol-3-phosphate o- acyltransferase 2). [swissprot;acc:o15120]	Measured	7556.75	8636.87	1.14293
	autoantigen ngp-1. [swissprot;acc:q13823]	Rooted	49.4756	53.9896	1.09124
	leukotriene a-4 hydrolase (ec 3.3.2.6) (lta-4 hydrolase) (leukotriene a(4) hydrolase). [swissprot;acc:p09960]	Squared	23512.2	28206.2	1.19964

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.