MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Value Type	Gene	Filtered	Rank	Network Comparison Type	red	Interaction Map	green	network_comparison	description

Results: HTML CSV LaTeX

Showing element 501 to 550 of 19268 in total

Value Type  : Ranked
Filtered  : 0

Rank	Network Comparison Type	red	Interaction Map	green	network_comparison	description
126	Divided	9722.71	High confidence	11493.8	1.18216	ret finger protein 2 (leukemia associated protein 5) (b-cell chronic lymphocytic leukemia tumor suppressor leu5) (putative tumor suppressor rfp2) (tripartite motif protein 13). [swissprot;acc:o60858]
		14899.4	Low confidence	17562.2	1.17872	bromodomain adjacent to zinc finger domain protein 1a (atp-utilizing chromatin assembly and remodeling factor 1) (hacf1) (atp-dependent chromatin remodelling protein) (williams syndrome transcription factor-related chromatin remodeling factor 180) (wcrf180) (hwalp1) (chrac subunit acf1) (hspc317). [swissprot;acc:q9nrl2]
	Subtracted	12314.9	High confidence	10489.3	1825.6	cytochrome p450 4f2 (ec 1.14.13.30) (cypivf2) (leukotriene-b4 omega- hydroxylase) (leukotriene-b4 20-monooxygenase) (cytochrome p450- ltb-omega). [swissprot;acc:p78329]
		15945.5	Low confidence	14123.3	1822.2	putative protein-tyrosine phosphatase tpte (ec 3.1.3.48). [swissprot;acc:p56180]
127	Divided	9411.34	High confidence	11119.7	1.18152	trans-prenyltransferase; polyprenyl pyrophosphate synthetase. [refseq;acc:nm_014317]
		10041.1	Low confidence	11814.4	1.1766	scribble. [refseq;acc:nm_015356]
	Subtracted	11732	High confidence	13530.6	1798.6	ccr4-not transcription complex, subunit 7 (ccr4-associated factor 1) (caf1) (btg1 binding factor 1). [swissprot;acc:q9uiv1]
		16660.8	Low confidence	18475.5	1814.7	dna helicase homolog (fragment). [sptrembl;acc:q9y645]
128	Divided	9259.51		10879.6	1.17496	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 like subunit. [swissprot;acc:q9y3k8]
		11564.4	High confidence	9794.29	1.18073	60s ribosomal protein l39. [swissprot;acc:p02404]
	Subtracted	9722.71		11493.8	1771.09	ret finger protein 2 (leukemia associated protein 5) (b-cell chronic lymphocytic leukemia tumor suppressor leu5) (putative tumor suppressor rfp2) (tripartite motif protein 13). [swissprot;acc:o60858]
		11161.3	Low confidence	12965.5	1804.2	lifeguard; kiaa0950 protein. [refseq;acc:nm_012306]
129	Divided	9248.93		10865.5	1.17478	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-4 subunit. [swissprot;acc:p50150]
		14222.5	High confidence	12058.6	1.17945	isoleucyl-trna synthetase, cytoplasmic (ec 6.1.1.5) (isoleucine--trna ligase) (ilers) (irs). [swissprot;acc:p41252]
	Subtracted	11564.4		9794.29	1770.11	60s ribosomal protein l39. [swissprot;acc:p02404]
		13206.7	Low confidence	15008.1	1801.4	piwi-like 2; miwi like. [refseq;acc:nm_018068]
130	Divided	14476.2	High confidence	17069.5	1.17914	enigma protein; lim domain protein. [refseq;acc:nm_005451]
		16024.9	Low confidence	13646	1.17433	sedlin. [swissprot;acc:o14582]
	Subtracted	10041.1		11814.4	1773.3	scribble. [refseq;acc:nm_015356]
		14922.7	High confidence	13174.5	1748.2	potassium voltage-gated channel, shal-related subfamily, member 2; voltage-sensitive potassium channel; voltage-gated potassium channel kv4.2. [refseq;acc:nm_012281]
131	Divided	4793.5	Low confidence	5609	1.17013	mitochondrial 39s ribosomal protein l39 (l39mt) (mrp-l39) (mrp-l5) (pred22 protein). [swissprot;acc:q9nyk5]
		8375.43	High confidence	9873.58	1.17887	dna mismatch repair protein mlh1 (mutl protein homolog 1). [swissprot;acc:p40692]
	Subtracted	14951.6		13204.2	1747.4	integral membrane protein cii-3b. [sptrembl;acc:o75609]
		15039.8	Low confidence	13277.6	1762.2	transcription factor bteb4 (basic transcription element binding- protein 4) (bte-binding protein 4) (krueppel-like factor 16) (novel sp1-like zinc finger transcription factor 2) (transcription factor nslp2). [swissprot;acc:q9bxk1]
132	Divided	16411.9		14027.1	1.17001	mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476]
		19048	High confidence	22389	1.1754	rna helicase-related protein; rna helicase-like protein; sf3b125 dead-box protein. [refseq;acc:nm_007372]
	Subtracted	10883		12622.8	1739.8	myosin va (myosin 5a) (dilute myosin heavy chain, non-muscle) (myosin heavy chain 12) (myoxin). [swissprot;acc:q9y4i1]
		12716.5	Low confidence	10962.4	1754.1	glutathione s-transferase theta 2 (ec 2.5.1.18) (gst class-theta). [swissprot;acc:p30712]
133	Divided	6814	High confidence	8009	1.17537	alpha-parvin (calponin-like integrin-linked kinase binding protein) (ch-ilkbp). [swissprot;acc:q9nvd7]
		11236.1	Low confidence	13113.5	1.16709	alpha-amylase, salivary precursor (ec 3.2.1.1) (1,4-alpha-d-glucan glucanohydrolase). [swissprot;acc:p04745]
	Subtracted	14922.7		13174.5	1748.2	potassium voltage-gated channel, shal-related subfamily, member 2; voltage-sensitive potassium channel; voltage-gated potassium channel kv4.2. [refseq;acc:nm_012281]
		17144.8	High confidence	15405.6	1739.2	mms19-like (met18 homolog, s. cerevisiae); homolog of yeast mms19; mms19 (met18 s. cerevisiae)-like. [refseq;acc:nm_022362]
134	Divided	9210.38	Low confidence	7893.05	1.1669	sorcin (22 kda protein) (cp-22) (v19). [swissprot;acc:p30626]
		12314.9	High confidence	10489.3	1.17404	cytochrome p450 4f8 (ec 1.14.14.1) (cypivf8). [swissprot;acc:p98187]
	Subtracted	12157.6		13890.3	1732.7	signal recognition particle 9 kda protein (srp9). [swissprot;acc:p49458]
		16853	Low confidence	15123	1730	maspin precursor (protease inhibitor 5). [swissprot;acc:p36952]
135	Divided	12314.9	High confidence	10489.3	1.17404	cytochrome p450 4f2 (ec 1.14.13.30) (cypivf2) (leukotriene-b4 omega- hydroxylase) (leukotriene-b4 20-monooxygenase) (cytochrome p450- ltb-omega). [swissprot;acc:p78329]
		15432.9	Low confidence	13250	1.16475	phosphatidylinositol 4-kinase alpha (ec 2.7.1.67) (pi4-kinase) (ptdins-4-kinase) (pi4k-alpha). [swissprot;acc:p42356]
	Subtracted	8871.11	High confidence	10603.2	1732.09	bloom's syndrome protein (ec 3.6.1.-) (recq protein-like 3) (dna helicase, recq-like, type 2). [swissprot;acc:p54132]
		16853	Low confidence	15123	1730	serpin b11. [swissprot;acc:q96p15]
136	Divided	12024.2		13977.2	1.16242	signal recognition particle 9 kda protein (srp9). [swissprot;acc:p49458]
		12335.3	High confidence	10506.8	1.17403	cytochrome p450 4f12 (ec 1.14.14.1) (cypivf12). [swissprot;acc:q9hcs2]
	Subtracted	12759.4		11028.8	1730.6	polyposis locus protein 1-like 1; likely ortholog of mouse polyposis locus protein 1-like 1. [refseq;acc:nm_138393]
		16853	Low confidence	15123	1730	cytoplasmic antiproteinase 2 (cap2) (cap-2) (protease inhibitor 8) (serpin b8). [swissprot;acc:p50452]
137	Divided	11161.3		12965.5	1.16165	lifeguard; kiaa0950 protein. [refseq;acc:nm_012306]
		12328.5	High confidence	10501	1.17403	cytochrome p450 4f11 (ec 1.14.14.1) (cypivf11). [swissprot;acc:q9hbi6]
	Subtracted	16853		15123	1730	maspin precursor (protease inhibitor 5). [swissprot;acc:p36952]
		19314	Low confidence	21041	1727	homogentisate 1,2-dioxygenase (ec 1.13.11.5) (homogentisicase) (homogentisate oxygenase) (homogentisic acid oxidase). [swissprot;acc:q93099]
138	Divided	8730		7516	1.16152	zinc finger protein-like 1; zinc-finger protein in men1 region. [refseq;acc:nm_006782]
		12384.7	High confidence	10549.4	1.17397	likely ortholog of rat cytochrome p450 4x1. [refseq;acc:nm_178033]

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.