MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Hugo	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 2325 to 2374 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Hugo	Network Comparison Type	red	green	network_comparison
1163	adp-ribosylation factor-like protein 4. [swissprot;acc:p40617]	ARL4A	Subtracted	218.402	212.904	5.498
	snare associated protein snapin. [refseq;acc:nm_012437]	SNAPAP	Divided	220.758	215.097	1.02632
1164	2-oxoglutarate dehydrogenase e1 component, mitochondrial precursor (ec 1.2.4.2) (alpha-ketoglutarate dehydrogenase). [swissprot;acc:q02218]	OGDH	Subtracted	208.55	214.041	5.491
	transducin-like enhancer protein 4. [swissprot;acc:q04727]	TLE4	Divided	219.438	213.818	1.02628
1165	caspase-7 precursor (ec 3.4.22.-) (ice-like apoptotic protease 3) (ice-lap3) (apoptotic protease mch-3) (cmh-1). [swissprot;acc:p55210]	CASP7	Subtracted	233.942	228.46	5.482
	transducin-like enhancer protein 3 (esg3). [swissprot;acc:q04726]	TLE3	Divided	219.401	213.785	1.02627
1166	apopain precursor (ec 3.4.22.-) (cysteine protease cpp32) (yama protein) (cpp-32) (caspase-3) (casp-3) (srebp cleavage activity 1) (sca-1). [swissprot;acc:p42574]	CASP3	Subtracted	233.942	228.46	5.482
	transducin-like enhancer protein 2 (esg2). [swissprot;acc:q04725]	TLE2	Divided	219.374	213.759	1.02627
1167	homeobox protein engrailed-2 (hu-en-2). [swissprot;acc:p19622]	EN2		219.399	213.784	1.02626
	mstp028 protein. [refseq;acc:nm_031954]	KCTD10	Subtracted	219.042	213.6	5.442
1168	cpg binding protein (protein containing phd finger and cxxc domain 1). [swissprot;acc:q9p0u4]	CXXC1	Divided	219.399	213.784	1.02626
	swi/snf related, matrix associated, actin dependent regulator of chromatin subfamily b member 1 (integrase interactor 1 protein) (hsnf5) (baf47). [swissprot;acc:q12824]	SMARCB1	Subtracted	219.03	213.604	5.426
1169	activator of basal transcription 1; tata-binding protein-binding protein; basal transcriptional activator. [refseq;acc:nm_013375]	ABT1	Divided	219.399	213.784	1.02626
	tumor necrosis factor, alpha-induced protein 1, endothelial (b12 protein). [swissprot;acc:q13829]	TNFAIP1	Subtracted	219.023	213.606	5.417
1170	cytokine-like nuclear factor n-pac. [refseq;acc:nm_032569]	no value	Divided	219.399	213.784	1.02626
	polymerase delta-interacting protein 1; tnfaip1-like. [refseq;acc:nm_178863]	KCTD13	Subtracted	219.022	213.607	5.415
1171	hect type e3 ubiquitin ligase. [refseq;acc:nm_015052]	HECW1	Divided	219.399	213.784	1.02626
	t-complex associated-testis-expressed 1-like (protein 91/23). [swissprot;acc:p51808]	DYNLT3	Subtracted	173.475	178.889	5.414
1172	double-strand break repair protein mre11a (mre11 homolog 1). [swissprot;acc:p49959]	MRE11A
	transducin-like enhancer protein 1 (esg1). [swissprot;acc:q04724]	no value	Divided	219.375	213.767	1.02623
1173	candidate tumor suppressor in ovarian cancer 2. [refseq;acc:nm_080822]	DPH1		229.243	235.246	1.02619
	coatomer beta subunit (beta-coat protein) (beta-cop). [swissprot;acc:p53618]	COPB1	Subtracted	171.341	176.746	5.405
1174	chromosome 11 open reading frame2; chromosome 11 open reading frame2. [refseq;acc:nm_013265]	C11orf2		214.364	219.759	5.395
	coatomer epsilon subunit (epsilon-coat protein) (epsilon-cop). [swissprot;acc:o14579]	COPE	Divided	187.964	192.849	1.02599
1175	kinesin-like protein kif13a (kinesin-like protein rbkin). [swissprot;acc:q9h1h9]	KIF13A	Subtracted	214.364	219.759	5.395
	vacuolar atp synthase 16 kda proteolipid subunit (ec 3.6.3.14). [swissprot;acc:p27449]	ATP6V0C	Divided	218.186	212.672	1.02593
1176	conserved oligomeric golgi complex component 2 (low density lipoprotein receptor defect c-complementing protein). [swissprot;acc:q14746]	COG2	Subtracted	214.364	219.759	5.395
	sarcoglycan zeta; zeta-sarcoglycan. [refseq;acc:nm_139167]	SGCZ	Divided	218.186	212.672	1.02593
1177	golgi complex associated protein 1; golgi resident protein gcp60; peripherial benzodiazepine receptor associated protein; golgi phosphoprotein 1; pbr associated protein; pka (rialpha)-associated protein. [refseq;acc:nm_022735]	ACBD3
	kinesin-like protein kif13b (kinesin-like protein gakin). [swissprot;acc:q9nqt8]	no value	Subtracted	214.364	219.759	5.395
1178	delta-sarcoglycan (sg-delta) (35 kda dystrophin-associated glycoprotein) (35dag). [swissprot;acc:q92629]	SGCD	Divided	218.186	212.672	1.02593
	metaxin 1. [swissprot;acc:q13505]	MTX1	Subtracted	199.552	204.925	5.373
1179	cellular modulator of immune recognition. [refseq;acc:nm_145021]	MARCH8	Divided	218.186	212.672	1.02593
	keratin associated protein 9-4; keratin associated protein 9.4. [refseq;acc:nm_033191]	no value	Subtracted	219.356	224.723	5.367
1180	succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial precursor (ec 1.3.5.1) (fp) (flavoprotein subunit of complex ii). [swissprot;acc:p31040]	SDHA		210.986	216.344	5.358
	vacuolar atp synthase 21 kda proteolipid subunit (ec 3.6.3.14) (hatpl). [swissprot;acc:q99437]	ATP6V0B	Divided	218.186	212.672	1.02593
1181	daz associated protein 1 isoform b; deleted in azoospermia associated protein 1. [refseq;acc:nm_018959]	DAZAP1	Subtracted	218.268	212.916	5.352
	gamma-sarcoglycan (gamma-sg) (35 kda dystrophin-associated glycoprotein) (35dag). [swissprot;acc:q13326]	SGCG	Divided	218.186	212.672	1.02593
1182	neurocalcin delta. [swissprot;acc:p29554]	NCALD		225.104	230.931	1.02589
	retinoic acid induced 17; pias-like protein hzimp10. [refseq;acc:nm_020338]	ZMIZ1	Subtracted	218.269	212.918	5.351
1183	keratin associated protein 4-14; keratin associated protein 4.14. [refseq;acc:nm_033059]	no value		219.354	224.7	5.346
	neuron specific calcium-binding protein hippocalcin (p23k) (calcium- binding protein bdr-2). [swissprot;acc:p32076]	HPCA	Divided	225.103	230.928	1.02588
1184	arf gtpase-activating protein git1 (g protein-coupled receptor kinase- interactor 1). [swissprot;acc:q9y2x7]	GIT1		216.729	222.334	1.02586
	keratin associated protein 4.9 (fragment). [sptrembl;acc:q9byq8]	no value	Subtracted	219.354	224.7	5.346
1185	keratin associated protein 4-12; keratin associated protein 4.12. [refseq;acc:nm_031854]
	visinin-like protein 3 (vilip-3) (calcium-binding protein bdr-1) (hlp2) (hippocalcin-like protein 1). [swissprot;acc:p37235]	HPCAL1	Divided	225.094	230.913	1.02585
1186	adp-ribosylation factor-like protein 7 (adp-ribosylation factor-like protein lak). [swissprot;acc:p56559]	no value		218.402	212.904	1.02582
	star-related lipid transfer protein 6 (stard6) (start domain- containing protein 6). [swissprot;acc:p59095]	STARD6	Subtracted	219.354	224.7	5.346
1187	star-related lipid transfer protein 5 (stard5) (start domain- containing protein 5). [swissprot;acc:q9nsy2]	STARD5
	vacuolar atp synthase subunit d (ec 3.6.3.14) (v-atpase d subunit) (vacuolar proton pump d subunit) (v-atpase ac39 subunit) (v-atpase 40 kda accessory protein) (p39) (32 kda accessory protein). [swissprot;acc:p12953]	ATP6V0D1	Divided	218.402	212.904	1.02582

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.