MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Network Comparison Type	Hugo	Value Type	description	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1582 to 1631 of 16578 in total

Value Type  : Ranked
Filtered  : 1

Rank	Network Comparison Type	Hugo	description	Interaction Map	red	green	network_comparison
396	Divided	LEPR	leptin receptor gene-related protein (ob-r gene related protein) (ob- rgrp). [swissprot;acc:o15243]	Low confidence	206.88	199.607	1.03644
	Subtracted	RPA1	replication protein a 70 kda dna-binding subunit (rp-a) (rf-a) (replication factor-a protein 1) (single-stranded dna-binding protein). [swissprot;acc:p27694]	High confidence	207.908	226.218	18.31
		SNRPD3	small nuclear ribonucleoprotein sm d3 (snrnp core protein d3) (sm-d3). [swissprot;acc:p43331]	Low confidence	201.176	193.984	7.192
397	Divided	CCT3	t-complex protein 1, gamma subunit (tcp-1-gamma) (cct-gamma). [swissprot;acc:p49368]	High confidence	110.689	101.613	1.08932
		LEPROTL1	leptin receptor overlapping transcript-like 1 (my047 protein). [swissprot;acc:o95214]	Low confidence	206.88	199.607	1.03644
	Subtracted	OXA1L	cytochrome oxidase biogenesis protein oxa1, mitochondrial precursor (oxa1-like protein) (oxa1hs). [swissprot;acc:q15070]		211.182	203.991	7.191
		RPA2	replication protein a 32 kda subunit (rp-a) (rf-a) (replication factor-a protein 2). [swissprot;acc:p15927]	High confidence	207.908	226.218	18.31
398	Divided	ITGB1BP3	muscle-specific beta 1 integrin binding protein. [refseq;acc:nm_014446]		218.818	238.358	1.0893
		YME1L1	yme1-like 1 isoform 3; atp-dependent metalloprotease ftsh1 homolog. [refseq;acc:nm_014263]	Low confidence	205.997	213.496	1.0364
	Subtracted	GNG10	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-10 subunit. [swissprot;acc:p50151]		207.797	214.954	7.157
		PDC	phosducin (phd) (33 kda phototransducing protein) (meka protein). [swissprot;acc:p20941]	High confidence	207.908	226.218	18.31
399	Divided	CLTC	clathrin heavy chain 1 (clh-17). [swissprot;acc:q00610]		207.889	226.226	1.08821
		GTF3A	transcription factor iiia (factor a) (tfiiia). [swissprot;acc:q92664]	Low confidence	193.291	186.506	1.03638
	Subtracted	no value	sirtuin 7; sir2-related protein type 7; sirtuin type 7; sirtuin (silent mating type information regulation 2, s.cerevisiae, homolog) 7; silent mating type information regulation 2, s.cerevisiae, homolog 7; sirtuin silent mating type information regulation 2 homolog 7 (s. cerevisiae). [refseq;acc:nm_016538]		205.017	197.863	7.154
		RAD52	dna repair protein rad52 homolog. [swissprot;acc:p43351]	High confidence	207.908	226.218	18.31
400	Divided	PDCL	phosducin-like protein (phlp). [swissprot;acc:q13371]				1.08807
		SLC35E1	solute carrier family 35, member e1. [refseq;acc:nm_024881]	Low confidence	203.661	211.03	1.03618
	Subtracted	CLTCL1	clathrin heavy chain 2 (clh-22). [swissprot;acc:p53675]	High confidence	207.931	226.209	18.278
		NUBP1	nucleotide-binding protein 1 (nbp 1). [swissprot;acc:p53384]	Low confidence	200.894	193.766	7.128
401	Divided	no value	sirtuin 7; sir2-related protein type 7; sirtuin type 7; sirtuin (silent mating type information regulation 2, s.cerevisiae, homolog) 7; silent mating type information regulation 2, s.cerevisiae, homolog 7; sirtuin silent mating type information regulation 2 homolog 7 (s. cerevisiae). [refseq;acc:nm_016538]		205.017	197.863	1.03616
		RPA1	replication protein a 70 kda dna-binding subunit (rp-a) (rf-a) (replication factor-a protein 1) (single-stranded dna-binding protein). [swissprot;acc:p27694]	High confidence	207.908	226.218	1.08807
	Subtracted	HTRA1	serine protease htra1 precursor (ec 3.4.21.-) (l56). [swissprot;acc:q92743]	Low confidence	200.057	192.938	7.119
		MKI67IP	mki67 (fha domain) interacting nucleolar phosphoprotein; nucleolar phosphoprotein nopp34; nucleolar protein interacting with the fha domain of pki-67. [refseq;acc:nm_032390]	High confidence	254.434	236.224	18.21
402	Divided	RPA2	replication protein a 32 kda subunit (rp-a) (rf-a) (replication factor-a protein 2). [swissprot;acc:p15927]		207.908	226.218	1.08807
		TREX2	x-linked protein sts1769. [swissprot;acc:q99871]	Low confidence	211.253	203.883	1.03615
	Subtracted	CACNG5	voltage-dependent calcium channel gamma-5 subunit (neuronal voltage- gated calcium channel gamma-5 subunit). [swissprot;acc:q9uf02]		210.292	203.181	7.111
		NDC80	highly expressed in cancer, rich in leucine heptad repeats. [refseq;acc:nm_006101]	High confidence	231.802	249.983	18.181
403	Divided	ATRIP	three prime repair exonuclease 1 isoform c; deoxyribonuclease iii, dnaq/mutd (e. coli)-like; 3' repair exonuclease 1; atr interacting protein. [refseq;acc:nm_032166]	Low confidence	211.253	203.883	1.03615
		PDC	phosducin (phd) (33 kda phototransducing protein) (meka protein). [swissprot;acc:p20941]	High confidence	207.908	226.218	1.08807
	Subtracted	HTRA3	probable serine protease htra3 precursor (ec 3.4.21.-). [swissprot;acc:p83110]	Low confidence	200.049	192.942	7.107
		MACF1	microtubule-actin crosslinking factor 1, isoform 4. [swissprot;acc:q96pk2]	High confidence	228.468	246.338	17.87
404	Divided	GRM2	metabotropic glutamate receptor 2 precursor (mglur2). [swissprot;acc:q14416]	Low confidence	203.081	196	1.03613
		RAD52	dna repair protein rad52 homolog. [swissprot;acc:p43351]	High confidence	207.908	226.218	1.08807
	Subtracted	DST	bullous pemphigoid antigen 1 isoforms 1/2/3/4/5/8 (230 kda bullous pemphigoid antigen) (bpa) (hemidesmosomal plaque protein) (dystonia musculorum protein) (fragment). [swissprot;acc:q03001]		228.463	246.33	17.867
		HTRA4	probable serine protease htra4 precursor (ec 3.4.21.-). [swissprot;acc:p83105]	Low confidence	200.049	192.942	7.107
405	Divided	no value	metabotropic glutamate receptor 3 precursor (mglur3). [swissprot;acc:q14832]		203.081	196	1.03613
		CLTCL1	clathrin heavy chain 2 (clh-22). [swissprot;acc:p53675]	High confidence	207.931	226.209	1.0879
	Subtracted	AP1G1	adapter-related protein complex 1 gamma 1 subunit (gamma-adaptin) (adaptor protein complex ap-1 gamma-1 subunit) (golgi adaptor ha1/ap1 adaptin gamma-1 subunit) (clathrin assembly protein complex 1 gamma-1 large chain). [swissprot;acc:o43747]	Low confidence	207.442	200.339	7.103
		GABARAP	gaba(a) receptor-associated protein; gaba(a)-receptor-associated protein. [refseq;acc:nm_007278]	High confidence	65.4586	83.0461	17.5875
406	Divided	no value	transcription factor dp-1 (e2f dimerization partner 1) (drtf1- polypeptide-1) (drtf1). [swissprot;acc:q14186]		265.634	244.304	1.08731
		LUC7L2	luc7-like 2; cgi-74 protein; cgi-59 protein. [refseq;acc:nm_016019]	Low confidence	201.095	194.099	1.03604
	Subtracted	HTRA2	serine protease htra2, mitochondrial precursor (ec 3.4.21.-) (high temperature requirement protein a2) (htra2) (omi stress-regulated endoprotease) (serine proteinase omi). [swissprot;acc:o43464]		200.046	192.943	7.103
		NETO2	neuropilin- and tolloid-like protein 2 precursor. [refseq;acc:nm_018092]	High confidence	237.109	254.667	17.558
407	Divided	LUC7L	luc7-like; sarcoplasmic reticulum protein luc7b1. [refseq;acc:nm_018032]	Low confidence	201.123	194.127	1.03604
		MRPS9	28s ribosomal protein s9, mitochondrial precursor (mrp-s9). [swissprot;acc:p82933]	High confidence	239.75	260.544	1.08673
	Subtracted	no value	small nuclear ribonucleoprotein e (snrnp-e) (sm protein e) (sm-e) (sme). [swissprot;acc:p08578]	Low confidence	201.334	194.242	7.092
		NETO1	neuropilin- and tolloid-like protein 1 isoform 3 precursor. [refseq;acc:nm_138966]	High confidence	237.109	254.667	17.558
408	Divided	CEBPZ	ccaat-box-binding transcription factor (ccaat-binding factor) (cbf). [swissprot;acc:q03701]		255.112	234.804	1.08649
		JPH4	adapter-related protein complex 1 gamma 2 subunit (gamma2-adaptin) (adaptor protein complex ap-1 gamma-2 subunit) (g2ad). [swissprot;acc:o75843]	Low confidence	207.558	200.363	1.03591
	Subtracted	GRM2	metabotropic glutamate receptor 2 precursor (mglur2). [swissprot;acc:q14416]		203.081	196	7.081

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.