MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	Gene	Rank	Hugo	Network Comparison Type	Value Type	Interaction Map	Filtered	red	green	network_comparison

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Showing element 1 to 50 of 25824 in total

Interaction Map  : High confidence
Filtered  : 1

description	Rank	Hugo	Network Comparison Type	Value Type	red	green	network_comparison
1,4-alpha-glucan branching enzyme (ec 2.4.1.18) (glycogen branching enzyme) (brancher enzyme). [swissprot;acc:q04446]	18	GBE1	Divided	Ranked	185.678	245.247	1.32082
	54		Subtracted				59.569
	60		Divided	Measured	4489.19	2765.82	1.6231
	64			Rooted	63.8686	47.2654	1.35128
	67		Subtracted				16.6032
	164			Measured	4489.19	2765.82	1723.37
	245		Divided	Squared	8875.01	6768.05	1.31131
	1962		Subtracted				2106.96
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha (ec 2.3.1.51) (1- agp acyltransferase 1) (1-agpat 1) (lysophosphatidic acid acyltransferase-alpha) (lpaat-alpha) (1-acylglycerol-3-phosphate o- acyltransferase 1) (g15 protein). [swissprot;acc:q99943]	274	no value			30807.7	39351.7	8544
	295		Divided				1.27733
	310		Subtracted	Measured	7551.8	8630.06	1078.26
	509		Divided				1.14278
	610		Subtracted	Rooted	74.3557	79.1513	4.7956
	805		Divided				1.0645
	1038			Ranked	186.741	181.041	1.03148
	1120		Subtracted				5.7
1-acyl-sn-glycerol-3-phosphate acyltransferase beta (ec 2.3.1.51) (1- agp acyltransferase 2) (1-agpat 2) (lysophosphatidic acid acyltransferase-beta) (lpaat-beta) (1-acylglycerol-3-phosphate o- acyltransferase 2). [swissprot;acc:o15120]	273	AGPAT2		Squared	30826.5	39383.9	8557.4
	294		Divided				1.2776
	307		Subtracted	Measured	7556.75	8636.87	1080.12
	508		Divided				1.14293
	609		Subtracted	Rooted	74.3877	79.1931	4.8054
	804		Divided				1.0646
	1032			Ranked	186.664	180.943	1.03162
	1115		Subtracted				5.721
1-acyl-sn-glycerol-3-phosphate acyltransferase delta (ec 2.3.1.51) (1- agp acyltransferase 4) (1-agpat 4) (lysophosphatidic acid acyltransferase-delta) (lpaat-delta) (1-acylglycerol-3-phosphate o- acyltransferase 4). [swissprot;acc:q9nrz5]	280	AGPAT4		Squared	30566.4	38866.5	8300.1
	311		Divided				1.27154
	319		Subtracted	Measured	7477	8532.02	1055.02
	514		Divided				1.1411
	631		Subtracted	Rooted	73.8577	78.5795	4.7218
	822		Divided				1.06393
	1048			Ranked	187.96	182.308	1.031
	1128		Subtracted				5.652
1-acyl-sn-glycerol-3-phosphate acyltransferase gamma (ec 2.3.1.51) (1- agp acyltransferase 3) (1-agpat 3) (lysophosphatidic acid acyltransferase-gamma) (lpaat-gamma) (1-acylglycerol-3-phosphate o- acyltransferase 3). [swissprot;acc:q9nrz7]	279	AGPAT3		Squared	30596.2	38919.9	8323.7
	308		Divided				1.27205
	318		Subtracted	Measured	7485.08	8543.66	1058.58
	513		Divided				1.14143
	616		Subtracted	Rooted	73.9102	78.6514	4.7412
	811		Divided				1.06415
	1043			Ranked	187.834	182.137	1.03128
	1121		Subtracted				5.697
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 (ec 3.1.4.11) (phosphoinositide phospholipase c) (plc-beta-4) (phospholipase c-beta-4). [swissprot;acc:q15147]	3126	PLCB4	Divided	Measured	0.00001	0.00001	1
				Ranked
				Squared
				Rooted
			Subtracted	Measured	0	0	0
				Ranked
				Squared
				Rooted
10 kda heat shock protein, mitochondrial (hsp10) (10 kda chaperonin) (cpn10). [swissprot;acc:q04984]	588	HSPE1	Divided	Squared	23526.4	27879.3	1.18502
	688		Subtracted				4352.9

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.