MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Hugo	Value Type	Network Comparison Type	Interaction Map	Filtered	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 391 to 440 of 16578 in total

Value Type  : Ranked
Filtered  : 1

Rank	description	Hugo	Network Comparison Type	Interaction Map	red	network_comparison	green
98	solute carrier family 7 (cationic amino acid transporter, y+ system), member 6. [refseq;acc:nm_003983]	SLC7A6	Divided	Low confidence	200.497	1.0798	185.679
			Subtracted			14.818
99	eukaryotic translation initiation factor 4b (eif-4b). [swissprot;acc:p23588]	EIF4B	Divided			1.0798
			Subtracted			14.818
	jun dimerization protein. [refseq;acc:nm_130469]	no value		High confidence	204.641	43.684	160.957
	melanoma-associated antigen 1 (mage-1 antigen) (antigen mz2-e). [swissprot;acc:p43355]		Divided		88.2482	1.24949	110.265
100	b(0,+)-type amino acid transporter 1 (b(0,+)at) (glycoprotein- associated amino acid transporter b0,+at1). [swissprot;acc:p82251]	SLC7A9		Low confidence	200.497	1.0798	185.679
			Subtracted			14.818
	fos-related antigen 2. [swissprot;acc:p15408]	FOSL2		High confidence	204.641	43.595	161.046
	melanoma-associated antigen 10 (mage-10 antigen). [swissprot;acc:p43363]	MAGEA10	Divided		88.2482	1.24949	110.265
101	coagulation factor xiii a chain precursor (ec 2.3.2.13) (protein- glutamine gamma-glutamyltransferase a chain) (transglutaminase a chain). [swissprot;acc:p00488]	F13A1	Subtracted	Low confidence	226.395	14.682	211.713
	leucine zipper domain protein. [refseq;acc:nm_024589]	ROGDI	Divided		221.996	1.07579	238.82
	melanoma-associated antigen b1 (mage-b1 antigen) (mage-xp antigen) (dss-ahc critical interval mage superfamily 10) (dam10). [swissprot;acc:p43366]	MAGEB4		High confidence	88.2482	1.24949	110.265
	protein fosb (g0/g1 switch regulatory protein 3). [swissprot;acc:p53539]	FOSB	Subtracted		204.641	43.59	161.051
102	diacylglycerol kinase, theta (ec 2.7.1.107) (diglyceride kinase) (dgk- theta) (dag kinase theta). [swissprot;acc:p52824]	DGKQ	Divided	Low confidence	229.556	1.07543	213.456
	fos-related antigen 1 (fra-1). [swissprot;acc:p15407]	FOSL1	Subtracted	High confidence	204.642	43.574	161.068
	melanoma-associated antigen d2 (mage-d2 antigen) (breast cancer associated gene 1 protein) (bcg-1) (11b6) (hepatocellular carcinoma associated protein jcl-1). [swissprot;acc:q9unf1]	MAGED2	Divided		88.2482	1.24949	110.265
	protein-glutamine gamma-glutamyltransferase k (ec 2.3.2.13) (transglutaminase k) (tgase k) (tgk) (tg(k)) (transglutaminase 1) (epidermal tgase). [swissprot;acc:p22735]	TGM1	Subtracted	Low confidence	226.395	14.682	211.713
103	goodpasture antigen-binding protein (ec 2.7.1.37) (gpbp) (collagen type iv alpha 3 binding protein) (star-related lipid transfer protein 11) (stard11) (start domain-containing protein 11). [swissprot;acc:q9y5p4]	COL4A3BP			220.969	14.603	235.572
	transcription factor jun-b. [swissprot;acc:p17275]	JUNB		High confidence	201.144	42.276	158.868
	trophinin. [swissprot;acc:q12816]	TRO	Divided		88.2482	1.24949	110.265
	vacuolar protein sorting 16 (hvps16). [swissprot;acc:q9h269]	PTPRA		Low confidence	203.948	1.07538	189.652
104	adiponectin receptor 2. [refseq;acc:nm_024551]	ADIPOR2			219.277	1.07377	204.212
	homer, neuronal immediate early gene, 2; homer homolog 3 (drosophila). [refseq;acc:nm_004839]	HOMER2		High confidence	252.371	1.24926	202.016
	natural resistance-associated macrophage protein 1 (nramp 1). [swissprot;acc:p49279]	SLC11A1	Subtracted	Low confidence	225.666	14.559	211.107
	tar dna-binding protein-43 (tdp-43). [swissprot;acc:q13148]	TARDBP		High confidence	256.228	42.21	298.438
105	b9 protein; likely ortholog of mouse endothelial precursor protein b9. [refseq;acc:nm_015681]	B9D1		Low confidence	213.243	14.373	227.616
	guanine nucleotide-binding protein g(i)/g(s)/g(t) beta subunit 1 (transducin beta chain 1). [swissprot;acc:p04901]	GNB1	Divided	High confidence	266.716	1.24914	333.165
	transcription factor e2f1 (e2f-1) (retinoblastoma binding protein 3) (rbbp-3) (prb-binding protein e2f-1) (pbr3) (retinoblastoma-associated protein 1) (rbap-1). [swissprot;acc:q01094]	E2F1		Low confidence	220.497	1.07369	205.364
	transcription factor jun-d. [swissprot;acc:p17535]	JUND	Subtracted	High confidence	200.941	42	158.941
106	disks large-associated protein 3 (dap-3) (sap90/psd-95-associated protein 3) (sapap3) (psd-95/sap90 binding protein 3) (fragment). [swissprot;acc:o95886]	DLGAP3		Low confidence	197.731	14.338	212.069
	nostrin. [refseq;acc:nm_052946]	NOSTRIN		High confidence	209.299	39.888	249.187
	transcription factor e2f2 (e2f-2). [swissprot;acc:q14209]	E2F2	Divided	Low confidence	220.497	1.07369	205.364
	ubiquinone biosynthesis protein coq7 homolog (coenzyme q biosynthesis protein 7 homolog) (timing protein clk-1 homolog). [swissprot;acc:q99807]	COQ7		High confidence	252.329	1.24913	202.004
107	eap30 subunit of ell complex. [refseq;acc:nm_007241]	SNF8	Subtracted		209.299	39.888	249.187
	homer, neuronal immediate early gene, 1b. [refseq;acc:nm_004272]	HOMER1	Divided		252.309	1.24907	201.998
	mouse mammary turmor virus receptor homolog 1. [refseq;acc:nm_152832]	FAM89B		Low confidence	227.429	1.07293	211.97
	vacuolar protein sorting 16 (hvps16). [swissprot;acc:q9h269]	PTPRA	Subtracted		203.948	14.296	189.652
108	disks large-associated protein 2 (dap-2) (sap90/psd-95-associated protein 2) (sapap2) (psd-95/sap90 binding protein 2) (fragment). [swissprot;acc:q9p1a6]	no value			197.752	14.279	212.031
	disks large-associated protein 3 (dap-3) (sap90/psd-95-associated protein 3) (sapap3) (psd-95/sap90 binding protein 3) (fragment). [swissprot;acc:o95886]	DLGAP3	Divided		197.731	1.07251	212.069
	homer, neuronal immediate early gene, 3. [refseq;acc:nm_004838]	HOMER3		High confidence	252.296	1.24902	201.995
	liv-1 protein, estrogen regulated. [refseq;acc:nm_012319]	SLC39A6	Subtracted		209.299	39.888	249.187
109	cellular repressor of e1a-stimulated genes. [refseq;acc:nm_003851]	CREG1		Low confidence	197.762	14.251	212.013
	glutamate decarboxylase, 65 kda isoform (ec 4.1.1.15) (gad-65) (65 kda glutamic acid decarboxylase). [swissprot;acc:q05329]	GAD2		High confidence	209.299	39.888	249.187
	guanine nucleotide-binding protein beta subunit 4 (transducin beta chain 4). [swissprot;acc:q9hav0]	GNB4	Divided		266.933	1.24856	333.281
	neuralized-like. [refseq;acc:nm_004210]	NEURL		Low confidence	232.704	1.07239	216.996
110	cellular repressor of e1a-stimulated genes 2. [refseq;acc:nm_153836]	CREG2	Subtracted		197.763	14.248	212.011
	deltex 2. [refseq;acc:nm_020892]	DTX2	Divided	High confidence	333.144	1.2459	267.393
	disks large-associated protein 2 (dap-2) (sap90/psd-95-associated protein 2) (sapap2) (psd-95/sap90 binding protein 2) (fragment). [swissprot;acc:q9p1a6]	no value		Low confidence	197.752	1.07221	212.031
	gamma-soluble nsf attachment protein (snap-gamma) (n-ethylmaleimide- sensitive factor attachment protein, gamma). [swissprot;acc:q99747]	NAPG	Subtracted	High confidence	209.299	39.888	249.187

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.