MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Value Type	Interaction Map	Network Comparison Type	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1291 to 1340 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	Hugo	description	Network Comparison Type	red	green	network_comparison
646	SCOC	short coiled-coil protein; short coiled coil protein. [refseq;acc:nm_032547]	Divided	216.731	229.549	1.05914
	SIM1	single-minded homolog 1. [swissprot;acc:p81133]	Subtracted	226.497	214.355	12.142
647	DYNLL2	dynein light chain 2. [refseq;acc:nm_080677]	Divided	216.731	229.549	1.05914
	HOXA10	homeobox protein hox-a10 (hox-1h) (hox-1.8) (pl). [swissprot;acc:p31260]	Subtracted	214.257	202.125	12.132
648	HOXB9	homeobox protein hox-b9 (hox-2e) (hox-2.5). [swissprot;acc:p17482]			202.132	12.125
	MARS	methionyl-trna synthetase (ec 6.1.1.10) (methionine--trna ligase) (metrs). [swissprot;acc:p56192]	Divided	218.227	206.078	1.05895
649	EIF4E	eukaryotic translation initiation factor 4e (eif-4e) (eif4e) (mrna cap-binding protein) (eif-4f 25 kda subunit). [swissprot;acc:p06730]		233.725	220.751	1.05877
	HOXA9	homeobox protein hox-a9 (hox-1g). [swissprot;acc:p31269]	Subtracted	214.257	202.132	12.125
650	no value	u6 snrna-associated sm-like protein lsm7. [swissprot;acc:q9uk45]	Divided	228.986	216.276	1.05877
	HOXC9	homeobox protein hox-c9 (hox-3b). [swissprot;acc:p31274]	Subtracted	214.257	202.135	12.122
651	BAIAP3	bai1-associated protein 3; bai-associated protein 3. [refseq;acc:nm_003933]	Divided	233.725	220.751	1.05877
	GABRG3	gamma-aminobutyric-acid receptor gamma-3 subunit precursor (gaba(a) receptor). [swissprot;acc:q99928]	Subtracted	214.256	202.139	12.117
652	no value	tgf beta-inducible nuclear protein 1; hairy cell leukemia protein 1. [refseq;acc:nm_014886]	Divided	248.994	235.255	1.0584
	FOXG1	forkhead box protein g1c (forkhead-related protein fkhl3) (hfk3) (fragment). [swissprot;acc:q14488]	Subtracted	214.256	202.139	12.117
653	no value	dok-like protein. [refseq;acc:nm_024872]	Divided	216.504	204.622	1.05807
		interleukin-1 receptor-associated kinase 4; interleukin-1 receptor associated kinase 4. [refseq;acc:nm_016123]	Subtracted	214.256	202.139	12.117
654	DOK2	docking protein 2 (p56(dok-2)) (downstream of tyrosine kinase 2). [swissprot;acc:o60496]	Divided	216.504	204.622	1.05807
	JMJD6	phosphatidylserine receptor; phosphatidylserine receptor beta. [refseq;acc:nm_015167]	Subtracted	214.256	202.139	12.117
655	DOK1	docking protein 1 (p62(dok)) (downstream of tyrosine kinase 1) (pp62). [swissprot;acc:q99704]	Divided	216.504	204.622	1.05807
	GABRG1	gamma-aminobutyric-acid receptor gamma-1 subunit precursor (gaba(a) receptor). [swissprot;acc:q8n1c3]	Subtracted	214.256	202.14	12.116
656	FRK	tyrosine-protein kinase frk (ec 2.7.1.112) (nuclear tyrosine protein kinase rak). [swissprot;acc:p42685]	Divided	216.504	204.622	1.05807
	GABRA2	gamma-aminobutyric-acid receptor alpha-2 subunit precursor (gaba(a) receptor). [swissprot;acc:p47869]	Subtracted	214.256	202.14	12.116
657	GABRA6	gamma-aminobutyric-acid receptor alpha-6 subunit precursor (gaba(a) receptor). [swissprot;acc:q16445]
	SYN3	synapsin iii. [swissprot;acc:o14994]	Divided	229.072	216.576	1.0577
658	no value	aspartate beta-hydroxylase isoform b; junctin isoform 1; junctate; aspartyl/asparaginyl-beta-hydroxylase; peptide-aspartate beta-dioxygenase; humbug. [refseq;acc:nm_032468]
	GABRG2	gamma-aminobutyric-acid receptor gamma-2 subunit precursor (gaba(a) receptor). [swissprot;acc:p18507]	Subtracted	214.256	202.14	12.116
659	GABRA4	gamma-aminobutyric-acid receptor alpha-4 subunit precursor (gaba(a) receptor). [swissprot;acc:p48169]
	HEY1	hairy/enhancer-of-split related with yrpw motif 1 (hairy and enhancer of split related-1) (hesr-1) (cardiovascular helix-loop-helix factor 2) (hes-related repressor protein 2 herp2). [swissprot;acc:q9y5j3]	Divided	229.072	216.576	1.0577
660	ABLIM2	actin binding lim protein 2. [refseq;acc:nm_032432]
	GABRE	gamma-aminobutyric-acid receptor epsilon subunit precursor (gaba(a) receptor). [swissprot;acc:p78334]	Subtracted	214.256	202.14	12.116
661	GABRA1	gamma-aminobutyric-acid receptor alpha-1 subunit precursor (gaba(a) receptor). [swissprot;acc:p14867]
	HEYL	hairy/enhancer-of-split related with yrpw motif-like. [refseq;acc:nm_014571]	Divided	229.072	216.576	1.0577
662	GABRA3	gamma-aminobutyric-acid receptor alpha-3 subunit precursor (gaba(a) receptor). [swissprot;acc:p34903]	Subtracted	214.256	202.14	12.116
	SYN2	synapsin ii. [swissprot;acc:q92777]	Divided	229.072	216.576	1.0577
663	MRRF	mitochondrial ribosome recycling factor. [refseq;acc:nm_138777]
	NDUFA6	nadh-ubiquinone oxidoreductase b14 subunit (ec 1.6.5.3) (ec 1.6.99.3) (complex i-b14) (ci-b14). [swissprot;acc:p56556]	Subtracted	214.256	202.141	12.115
664	PDXDC1	similar to expressed sequence aa415817. [sptrembl;acc:q8n4q9]
	PEX5	peroxisomal targeting signal 1 receptor (peroxismore receptor 1) (peroxisomal c-terminal targeting signal import receptor) (pts1-bp) (peroxin-5) (pts1 receptor). [swissprot;acc:p50542]	Divided	229.072	216.576	1.0577
665	HEY2	hairy/enhancer-of-split related with yrpw motif 2; gridlock; hes-related repressor protein 1. [refseq;acc:nm_012259]
	HOXD9	homeobox protein hox-d9 (hox-4c) (hox-5.2). [swissprot;acc:p28356]	Subtracted	214.254	202.166	12.088
666	EIF3I	eukaryotic translation initiation factor 3 subunit 2 (eif-3 beta) (eif3 p36) (eif3i) (tgf-beta receptor interacting protein 1) (trip-1). [swissprot;acc:q13347]		250.465	238.38	12.085
	HES1	transcription factor hes-1 (hairy and enhancer of split 1) (hairy- like) (hhl) (hairy homolog). [swissprot;acc:q14469]	Divided	229.072	216.576	1.0577
667	no value	trinucleotide repeat containing 15. [refseq;acc:nm_015575]	Subtracted	250.465	238.38	12.085
	ECH1	delta3,5-delta2,4-dienoyl-coa isomerase, mitochondrial precursor (ec 5.3.3.-). [swissprot;acc:q13011]	Divided	229.072	216.576	1.0577
668	ABLIM1	actin-binding lim protein 1 isoform a; lim actin-binding protein 1; limatin; actin-binding lim protein. [refseq;acc:nm_002313]
	FTSJ3	ftsj homolog 3; likely ortholog of mouse ectoplacental cone, invasive trophoblast giant cells, extraembryonic ectoderm and chorion sequence 3. [refseq;acc:nm_017647]	Subtracted	244.495	232.419	12.076
669	no value	presenilin-like protein 2 (ec 3.4.99.-) (sppl2a protein). [swissprot;acc:q8tct8]		232.601	244.534	11.933
	SYN1	synapsin i (brain protein 4.1). [swissprot;acc:p17600]	Divided	229.072	216.576	1.0577
670	GNL2	autoantigen ngp-1. [swissprot;acc:q13823]		250.302	236.817	1.05694
	RANP1	gtp-binding nuclear protein ran (tc4) (ran gtpase) (androgen receptor- associated protein 24). [swissprot;acc:p17080]	Subtracted	232.601	244.534	11.933

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.