MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Network Comparison Type	description	Hugo	Value Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 2501 to 2550 of 8289 in total

Network Comparison Type  : Divided
Value Type  : Ranked
Filtered  : 1

Rank	description	Hugo	Interaction Map	red	green	network_comparison
1251	integrin-linked protein kinase 1 (ec 2.7.1.-) (ilk-1) (59 kda serine/threonine protein kinase) (p59ilk). [swissprot;acc:q13418]	ILK	High confidence	219.354	224.7	1.02437
	zinc finger protein zic 2 (zinc finger protein of the cerebellum 2). [swissprot;acc:o95409]	ZIC2	Low confidence	204.937	200.402	1.02263
1252	elav-like protein 2 (hu-antigen b) (hub) (elav-like neuronal protein 1) (nervous system-specific rna binding protein hel-n1). [swissprot;acc:q12926]	ELAVL2		202.261	197.788	1.02262
	star-related lipid transfer protein 4 (stard4) (start domain- containing protein 4). [swissprot;acc:q96dr4]	STARD4	High confidence	219.354	224.7	1.02437
1253	ras suppressor protein 1 (rsu-1) (rsp-1). [swissprot;acc:q15404]	RSU1
	syntaxin 18. [swissprot;acc:q9p2w9]	STX18	Low confidence	204.026	199.515	1.02261
1254	androgen-induced 1; cgi-103 protein; androgen induced protein. [refseq;acc:nm_016108]	AIG1
	ras-gtpase-activating protein binding protein 1 (gap sh3-domain binding protein 1) (g3bp-1). [swissprot;acc:q13283]	G3BP1	High confidence	219.354	224.7	1.02437
1255	mawd binding protein (unknown protein 32 from 2d-page of liver tissue). [swissprot;acc:p30039]	PBLD	Low confidence	185.205	181.112	1.0226
	ras-gtpase-activating protein binding protein 2 (gap sh3-domain binding protein 2) (g3bp-2). [swissprot;acc:q9un86]	G3BP2	High confidence	219.354	224.7	1.02437
1256	keratin associated protein 1-3; keratin associated protein 1.3. [refseq;acc:nm_030966]	no value			224.699
	serine/threonine-protein kinase receptor r2 precursor (ec 2.7.1.37) (skr2) (activin receptor-like kinase 4) (alk-4) (actr-ib). [swissprot;acc:p36896]	ACVR1B	Low confidence	204.05	199.543	1.02259
1257	activin a receptor, type ic; activin receptor-like kinase 7. [refseq;acc:nm_145259]	ACVR1C
	espin. [refseq;acc:nm_031475]	ESPNP	High confidence	219.354	224.7	1.02437
1258	cytochrome p450 2d6 (ec 1.14.14.1) (cypiid6) (p450-db1) (debrisoquine 4-hydroxylase). [swissprot;acc:p10635]	CYP2D6
	tgf-beta receptor type i precursor (ec 2.7.1.37) (tgfr-1) (tgf-beta type i receptor) (serine/threonine-protein kinase receptor r4) (skr4) (activin receptor-like kinase 5) (alk-5). [swissprot;acc:p36897]	TGFBR1	Low confidence	204.05	199.545	1.02258
1259	pleckstrin homology domain containing, family c (with ferm domain) member 1; mitogen inducible 2; kindlin 2. [refseq;acc:nm_006832]	PLEKHC1	High confidence	219.354	224.7	1.02437
	smp3 mannosyltransferase. [refseq;acc:nm_025163]	PIGZ	Low confidence	202.715	198.24	1.02257
1260	lim and senescent cell antigen-like domains 2; ilk-binding protein. [refseq;acc:nm_017980]	LIMS2	High confidence	219.354	224.7	1.02437
	protoheme ix farnesyltransferase, mitochondrial precursor (ec 2.5.1.-) (heme o synthase). [swissprot;acc:q12887]	COX10	Low confidence	199.952	195.538	1.02257
1261	d(4) dopamine receptor (d(2c) dopamine receptor). [swissprot;acc:p21917]	DRD4	High confidence	219.354	224.7	1.02437
	succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial precursor (cybs) (succinate-ubiquinone reductase membrane anchor subunit) (qps2) (cii-4) (succinate dehydrogenase complex subunit d) (succinate-ubiquinone oxidoreductase cytochrome b small subunit). [swissprot;acc:o14521]	no value	Low confidence	203.503	199.013	1.02256
1262	katanin p80 subunit b 1; katanin (80 kda); katanin p80 (wd40-containing) subunit b 1. [refseq;acc:nm_005886]	KATNB1		203.846	199.351	1.02255
	keratin associated protein 9.2. [refseq;acc:nm_031961]	KRTAP9-8	High confidence	219.353	224.678	1.02428
1263	mitogen-activated protein kinase 12 (ec 2.7.1.37) (extracellular signal-regulated kinase 6) (erk-6) (erk5) (stress-activated protein kinase-3) (mitogen-activated protein kinase p38 gamma) (map kinase p38 gamma). [swissprot;acc:p53778]	MAPK11		171.231	167.177	1.02425
	nuclear protein skip (ski-interacting protein) (snw1 protein) (nuclear receptor coactivator ncoa-62). [swissprot;acc:q13573]	SNW1	Low confidence	196.724	192.389	1.02253
1264	ras-related protein rab-11b (gtp-binding protein ypt3). [swissprot;acc:q15907]	RAB11B		203.934	199.445	1.02251
	sphingosine kinase 1 (ec 2.7.1.-) (sk 1) (spk 1). [swissprot;acc:q9nya1]	SPHK1	High confidence	171.231	167.177	1.02425
1265	kccr13l. [refseq;acc:nm_139179]	DAGLB	Low confidence	203.303	198.827	1.02251
	udp-n-acetylglucosamine--dolichyl-phosphate n- acetylglucosaminephosphotransferase (ec 2.7.8.15) (gpt) (g1pt) (n-acetylglucosamine-1-phosphate transferase) (glcnac-1-p transferase). [swissprot;acc:q9h3h5]	DPAGT1	High confidence	171.231	167.177	1.02425
1266	nadph:adrenodoxin oxidoreductase, mitochondrial precursor (ec 1.18.1.2) (adrenodoxin reductase) (ar) (ferredoxin-nadp(+) reductase). [swissprot;acc:p22570]	FDXR	Low confidence	201.264	196.834	1.02251
	rho-gtpase-activating protein 7 (rho-type gtpase-activating protein 7) (deleted in liver cancer 1 protein) (dlc-1) (hp protein) (star-related lipid transfer protein 12) (stard12) (start domain-containing protein 12). [swissprot;acc:q96qb1]	DLC1	High confidence	171.231	167.177	1.02425
1267	map kinase-activated protein kinase 2 (ec 2.7.1.-) (mapk-activated protein kinase 2) (mapkap kinase 2) (mapkapk-2). [swissprot;acc:p49137]	MAPKAPK2
	testis-specific histone h2b; h2b histone family, member u, (testis-specific). [refseq;acc:nm_170610]	HIST1H2BA	Low confidence	203.672	199.189	1.02251
1268	histidyl-trna synthetase homolog (ec 6.1.1.21) (histidine--trna ligase homolog) (hisrs). [swissprot;acc:p49590]	HARS2		192.905	188.658
	neuronal acetylcholine receptor protein, alpha-6 chain precursor. [swissprot;acc:q15825]	CHRNA6	High confidence	171.231	167.177	1.02425
1269	ectonucleoside triphosphate diphosphohydrolase 6 (ec 3.6.1.6) (ntpdase6) (cd39 antigen-like 2). [swissprot;acc:o75354]	no value	Low confidence	196.818	192.485	1.02251
	nitrogen fixation cluster-like. [refseq;acc:nm_014301]	ISCU	High confidence	171.231	167.177	1.02425
1270	cytochrome p450 2d6 (ec 1.14.14.1) (cypiid6) (p450-db1) (debrisoquine 4-hydroxylase). [swissprot;acc:p10635]	CYP2D6	Low confidence	201.858	197.415	1.02251
	star-related lipid transfer protein 13 (stard13) (start domain- containing protein 13) (46h23.2). [swissprot;acc:q9y3m8]	STARD13	High confidence	171.231	167.177	1.02425
1271	histidyl-trna synthetase (ec 6.1.1.21) (histidine--trna ligase) (hisrs). [swissprot;acc:p12081]	HARS	Low confidence	192.956	188.71	1.0225
	star-related lipid transfer protein 8 (stard8) (start domain- containing protein 8). [swissprot;acc:q92502]	STARD8	High confidence	171.231	167.177	1.02425
1272	ceramide glucosyltransferase (ec 2.4.1.80) (glucosylceramide synthase) (gcs) (udp-glucose:n-acylsphingosine d-glucosyltransferase) (glct-1). [swissprot;acc:q16739]	UGCG	Low confidence	192.933	188.687	1.0225
	neuronal acetylcholine receptor protein, alpha-2 chain precursor. [swissprot;acc:q15822]	CHRNA2	High confidence	171.231	167.177	1.02425
1273	mitogen-activated protein kinase-activated protein kinase 3; mapkap kinase 3. [refseq;acc:nm_004635]	MAPKAPK3
	protein-tyrosine phosphatase, non-receptor type 2 (ec 3.1.3.48) (t- cell protein-tyrosine phosphatase) (tcptp). [swissprot;acc:p17706]	PTPN2	Low confidence	200.744	196.329	1.02249
1274	cryptochrome 1 (photolyase-like). [refseq;acc:nm_004075]	CRY1		193.539	189.282
	mitogen-activated protein kinase 14 (ec 2.7.1.37) (mitogen-activated protein kinase p38alpha) (map kinase p38alpha) (cytokine suppressive anti-inflammatory drug binding protein) (csaid binding protein) (csbp) (max-interacting protein 2) (map kinase mxi2) (sapk2a). [swissprot;acc:q16539]	MAPK14	High confidence	171.231	167.177	1.02425
1275	histone h2b.q (h2b/q) (h2b-gl105). [swissprot;acc:q16778]	HIST2H2BA	Low confidence	203.671	199.194	1.02248
	neuronal acetylcholine receptor protein, alpha-4 chain precursor. [swissprot;acc:p43681]	CHRNA4	High confidence	171.231	167.177	1.02425

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.