MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Value Type	Gene	description	Interaction Map	Network Comparison Type	network_comparison	green	Rank	Filtered	red

Results: HTML CSV LaTeX

Showing element 51 to 100 of 38536 in total

Value Type  : Measured
Network Comparison Type  : Divided

description	Interaction Map	network_comparison	green	Rank	Filtered	red
25-hydroxyvitamin d-1 alpha hydroxylase, mitochondrial precursor (ec 1.14.-.-) (25-ohd-1 alpha-hydroxylase) (25-hydroxyvitamin d3 1- alpha-hydroxylase) (vd3 1a hydroxylase) (p450c1 alpha) (p450vd1- alpha). [swissprot;acc:o15528]	High confidence	1	0.00001	3079	1	0.00001
		11.6763	26.1599	19	0	305.45
	Low confidence	1.22585	181.734	171		222.779
		1.29112	3915.4	19	1	3032.56
26s protease regulatory subunit 4 (p26s4). [swissprot;acc:q03527]	High confidence	1.07379	6376.76	1521		5938.56
	Low confidence	1.03263	8422.67	1881		8156.56
26s protease regulatory subunit 6a (tat-binding protein 1) (tbp-1) (proteasome subunit p50). [swissprot;acc:p17980]	High confidence	1.07349	6362.33	1527		5926.76
	Low confidence	1.03218	8372.5	2003		8111.49
26s protease regulatory subunit 6b (mip224) (mb67 interacting protein) (tat-binding protein-7) (tbp-7). [swissprot;acc:p43686]	High confidence	1.07226	6242.94	1567		5822.25
	Low confidence	1.03623	8556.58	1203		8257.44
26s protease regulatory subunit 7 (mss1 protein). [swissprot;acc:p35998]	High confidence	1.07322	6207.5	1539		5783.97
	Low confidence	1.03794	8703.92	1024		8385.76
26s protease regulatory subunit 8 (proteasome subunit p45) (thyroid hormone receptor interacting protein 1) (trip1) (msug1 protein) (tat-binding protein homolog 10) (tbp10) (p45/sug). [swissprot;acc:p47210]	High confidence	1.00914	9234.09	2651		9150.44
	Low confidence	1.02789	8314.51	3044		8088.94
26s protease regulatory subunit s10b (proteasome subunit p42) (p44) (conserved atpase domain protein 44) (cadp44). [swissprot;acc:q92524]	High confidence	1.07181	6349.04	1577		5923.66
	Low confidence	1.02947	8326.51	2711		8088.12
26s proteasome non-atpase regulatory subunit 1 (26s proteasome regulatory subunit s1) (26s proteasome subunit p112). [swissprot;acc:q99460]	High confidence	1.06342	6195.48	1883		5826
	Low confidence	1.03046	8063.51	2447		7825.14
26s proteasome non-atpase regulatory subunit 10 (26s proteasome regulatory subunit p28) (gankyrin). [swissprot;acc:o75832]	High confidence	1.01545	2642.79	451	0	2683.61
		1.07134	6242.44	1609	1	5826.74
	Low confidence	1.01017	1609.88	771	0	1593.68
		1.0319	8397.56	2056	1	8137.96
26s proteasome non-atpase regulatory subunit 11 (26s proteasome regulatory subunit s9) (26s proteasome regulatory subunit p44.5). [swissprot;acc:o00231]	High confidence	1.07153	6271.79	1592		5853.1
	Low confidence	1.03984	8727.99	889		8393.58
26s proteasome non-atpase regulatory subunit 12 (26s proteasome regulatory subunit p55). [swissprot;acc:o00232]	High confidence	1.00763	2263.85	474	0	2281.12
		1.07179	6261.87	1579	1	5842.44
	Low confidence	1.00797	2331.31	785	0	2349.9
		1.03739	8671.34	1073	1	8358.82
26s proteasome non-atpase regulatory subunit 13 (26s proteasome regulatory subunit s11) (26s proteasome regulatory subunit p40.5). [swissprot;acc:q9unm6]	High confidence	1.07166	6278.32	1585		5858.48
	Low confidence	1.03225	8388.54	1982		8126.5
26s proteasome non-atpase regulatory subunit 2 (26s proteasome regulatory subunit s2) (26s proteasome subunit p97) (tumor necrosis factor type 1 receptor associated protein 2) (55.11 protein). [swissprot;acc:q13200]	High confidence	1.08451	6980.13	1241		6436.19
	Low confidence	1.03153	8521.25	2168		8260.81
26s proteasome non-atpase regulatory subunit 3 (26s proteasome regulatory subunit s3) (proteasome subunit p58). [swissprot;acc:o43242]	High confidence	1.07303	6244.37	1546		5819.39
	Low confidence	1.03175	8407.98	2101		8149.27
26s proteasome non-atpase regulatory subunit 4 (26s proteasome regulatory subunit s5a) (rpn10) (multiubiquitin chain binding protein) (antisecretory factor-1) (af) (asf). [swissprot;acc:p55036]	High confidence	1.05939	5800.97	1979		5475.74
	Low confidence	1.03275	8425.82	1826		8158.59
26s proteasome non-atpase regulatory subunit 6 (26s proteasome regulatory subunit s10) (p42a) (proteasome regulatory particle subunit p44s10). [swissprot;acc:q15008]	High confidence	1.07535	6435.42	1472		5984.47
	Low confidence	1.037	8441.1	1122		8139.9
26s proteasome non-atpase regulatory subunit 7 (26s proteasome regulatory subunit s12) (proteasome subunit p40) (mov34 protein homolog). [swissprot;acc:p51665]	High confidence	1.07208	6273.4	1571		5851.64
	Low confidence	1.02973	8358.6	2648		8117.3
26s proteasome non-atpase regulatory subunit 8 (26s proteasome regulatory subunit s14) (p31). [swissprot;acc:p48556]	High confidence	1.07344	6350.53	1536		5916.05
	Low confidence	1.03928	8445.39	917		8126.23
26s proteasome non-atpase regulatory subunit 9 (26s proteasome regulatory subunit p27). [swissprot;acc:o00233]	High confidence	1.07393	6439.46	1517		5996.14
	Low confidence	1.03429	8435.4	1454		8155.72
26s proteasome-associated pad1 homolog. [refseq;acc:nm_005805]	High confidence	1.06977	6186.39	1643		5782.92
	Low confidence	1.03218	8367.09	2004		8106.21
27 kda golgi snare protein (golgi snap receptor complex member 2) (membrin). [swissprot;acc:o14653]	High confidence	1.00351	5583.64	2720		5603.24
	Low confidence	1.10006	5567.34	103		5060.92
28s ribosomal protein s12, mitochondrial precursor (mpr-s12) (mt- rps12). [swissprot;acc:o15235]	High confidence	1.05302	3381.34	2153		3560.63
	Low confidence	1.01755	7505.02	4567		7375.6

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.