MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	red	Network Comparison Type	Gene	Rank	Hugo	network_comparison	Value Type	Interaction Map	Filtered	green

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Showing element 308 to 357 of 2060 in total

red  : 0
Network Comparison Type  : Subtracted
network_comparison  : 0
Filtered  : 1
green  : 0

description	Rank	Hugo	Value Type	Interaction Map
cop9 signalosome complex subunit 1 (g protein pathway suppressor 1) (gps1 protein) (mfh protein). [swissprot;acc:q13098]	2827	GPS1	Rooted	High confidence
cop9 signalosome complex subunit 2 (signalosome subunit 2) (sgn2) (thyroid receptor interacting protein 15) (trip15). [swissprot;acc:q15647]	2841	COPS2	Measured
			Ranked
			Squared
			Rooted
core-binding factor, beta subunit (cbf-beta) (polyomavirus enhancer binding protein 2 beta subunit) (pebp2-beta) (pea2-beta) (sl3-3 enhancer factor 1 beta subunit) (sl3/akv core-binding factor beta subunit). [swissprot;acc:q13951]	3183	CBFB	Measured
			Ranked
			Squared
			Rooted
	5059		Measured	Low confidence
			Ranked
			Squared
			Rooted
ctcl tumor antigen l14-2. [refseq;acc:nm_018017]	2846	C10orf118	Measured	High confidence
			Ranked
			Squared
			Rooted
cyclin h (mo15-associated protein) (p37) (p34). [swissprot;acc:p51946]	2983	CCNH	Measured
			Ranked
			Squared
			Rooted
cyclin k. [swissprot;acc:o75909]	3160	CCNK	Measured
			Ranked
			Squared
			Rooted
cyclin t1 (cyclin t) (cyct1). [swissprot;acc:o60563]	3002	CCNT1	Measured
			Ranked
			Squared
			Rooted
cyclin t2. [swissprot;acc:o60583]	3171	CCNT2	Measured
			Ranked
			Squared
			Rooted
cyclin-dependent kinase (cdc2-like) 11; death-preventing kinase. [refseq;acc:nm_015076]	2892	CDC2L6	Measured
			Ranked
			Squared
			Rooted
cyr61 protein precursor (cysteine-rich, angiogenic inducer, 61) (insulin-like growth factor-binding protein 10) (gig1 protein). [swissprot;acc:o00622]	2938	CYR61	Measured
			Ranked
			Squared
			Rooted
cysteine-rich secretory protein-1 precursor (crisp-1) (acidic epididymal glycoprotein homolog) (aeg-like protein) (arp). [swissprot;acc:p54107]	3018	CRISP1	Measured
			Ranked
			Squared
			Rooted
cysteine-rich secretory protein-3 precursor (crisp-3) (sgp28 protein). [swissprot;acc:p54108]	3150	CRISP3	Measured
			Ranked
			Squared
			Rooted
cytochrome c oxidase polypeptide va, mitochondrial precursor (ec 1.9.3.1). [swissprot;acc:p20674]	2791	COX5A	Measured

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.