MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	Rank	Gene	Hugo	Value Type	Network Comparison Type	Interaction Map	Filtered	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 82 to 131 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

description	Rank	Hugo	Network Comparison Type	red	network_comparison	green
27 kda golgi snare protein (golgi snap receptor complex member 2) (membrin). [swissprot;acc:o14653]	810	GOSR2	Divided	212.386	1.04425	221.785
28s ribosomal protein s12, mitochondrial precursor (mpr-s12) (mt- rps12). [swissprot;acc:o15235]	235	MRPS12	Subtracted	243.944	24.251	268.195
	325		Divided		1.09941
28s ribosomal protein s16, mitochondrial precursor (mrp-s16) (cgi- 132). [swissprot;acc:q9y3d3]	2151	MRPS16	Subtracted	224.411	1.443	225.854
	2212		Divided		1.00643
28s ribosomal protein s17, mitochondrial precursor (mrp-s17) (hspc011). [swissprot;acc:q9y2r5]	23	MRPS17		58	1.31818	44
	533		Subtracted		14
28s ribosomal protein s18a, mitochondrial precursor (mrp-s18-a) (mrps18a) (mrp-s18-3). [swissprot;acc:q9nvs2]	1656	MRPS18A		217.925	3.099	214.826
	1659		Divided		1.01443
28s ribosomal protein s26, mitochondrial precursor (mrp-s26) (mrp- s13). [swissprot;acc:q9byn8]	2673	MRPS26	Subtracted	214.893	0.215	215.108
	2675		Divided		1.001
28s ribosomal protein s9, mitochondrial precursor (mrp-s9). [swissprot;acc:p82933]	340	MRPS9	Subtracted	239.75	20.794	260.544
	407		Divided		1.08673
3 beta-hydroxy-delta 5-c27-steroid oxidoreductase. [refseq;acc:nm_025193]	3147	HSD3B7		0.00001	1	0.00001
			Subtracted	0	0	0
3 beta-hydroxysteroid dehydrogenase (fragments). [sptrembl;acc:q9udk8]	2756	no value	Divided	0.00001	1	0.00001
			Subtracted	0	0	0
3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase type i (3beta-hsd i) (trophoblast antigen fdo161g) [includes: 3-beta-hydroxy- delta(5)-steroid dehydrogenase (ec 1.1.1.145) (3-beta-hydroxy-5-ene steroid dehydrogenase) (progesterone reductase); steroid delta- isomerase (ec 5.3.3.1) (delta-5-3-ketosteroid isomerase)]. [swissprot;acc:p14060]	2802		Divided	0.00001	1	0.00001
			Subtracted	0	0	0
3-hydroxy-3-methylglutaryl-coenzyme a reductase (ec 1.1.1.34) (hmg-coa reductase). [swissprot;acc:p04035]	2303	HMGCR	Divided	191.567	1.00509	192.542
	2333		Subtracted		0.975
3-hydroxyacyl-coa dehydrogenase type ii (ec 1.1.1.35) (type ii hadh) (endoplasmic reticulum-associated amyloid beta-peptide binding protein) (short-chain type dehydrogenase/reductase xh98g2). [swissprot;acc:q99714]	3180	HSD17B10	Divided	0.00001	1	0.00001
			Subtracted	0	0	0
3-hydroxyanthranilate 3,4-dioxygenase (ec 1.13.11.6) (3-hao) (3-hydroxyanthranilic acid dioxygenase) (3-hydroxyanthranilate oxygenase). [swissprot;acc:p46952]	2189	HAAO	Divided	209.54	1.00662	208.162
	2201		Subtracted		1.378
3-hydroxyisobutyryl-coenzyme a hydrolase. [refseq;acc:nm_014362]	1852	no value	Divided	196.008	1.01095	198.154
	1914		Subtracted		2.146
3-ketoacyl-coa thiolase, peroxisomal precursor (ec 2.3.1.16) (beta- ketothiolase) (acetyl-coa acyltransferase) (peroxisomal 3-oxoacyl- coa thiolase). [swissprot;acc:p09110]	2300	ACAA1	Divided	191.563	1.00511	192.541
	2331		Subtracted		0.978
3-mercaptopyruvate sulfurtransferase (ec 2.8.1.2) (mst). [swissprot;acc:p25325]	1025	MPST	Divided	205.632	1.03195	199.266
	1048		Subtracted		6.366
3-oxo-5-alpha-steroid 4-dehydrogenase 1 (ec 1.3.99.5) (steroid 5-alpha-reductase 1) (sr type 1) (s5ar). [swissprot;acc:p18405]	1040	SRD5A1		220.118	6.433	213.685
	1083		Divided		1.03011
3-oxo-5-alpha-steroid 4-dehydrogenase 2 (ec 1.3.99.5) (steroid 5-alpha-reductase 2) (sr type 2) (5 alpha-sr2). [swissprot;acc:p31213]	1041	SRD5A2	Subtracted		6.433
	1084		Divided		1.03011
3-phosphoinositide dependent protein kinase-1 (ec 2.7.1.37) (hpdk1). [swissprot;acc:o15530]	739	PDPK1	Subtracted	272.878	10.594	283.472
	897		Divided		1.03882
38 kda fk-506 binding protein homolog (fkbpr38) (fk506-binding protein 8). [swissprot;acc:q14318]	2358	FKBP8		198.181	1.00423	197.346
	2385		Subtracted		0.835
4-aminobutyrate aminotransferase, mitochondrial precursor (ec 2.6.1.19) (gamma-amino-n-butyrate transaminase) (gaba transaminase) (gaba aminotransferase) (gaba-at) (gaba-t). [swissprot;acc:p80404]	1720	no value		219.423	2.792	222.215
	1745		Divided		1.01272
40s ribosomal protein s11. [swissprot;acc:p04643]	199	RPS11	Subtracted	241.399	25.689	267.088
	278		Divided		1.10642
40s ribosomal protein s13. [swissprot;acc:q02546]	1695	RPS13	Subtracted	220.899	2.914	223.813
	1722		Divided		1.01319
40s ribosomal protein s14 (pro2640). [swissprot;acc:p06366]	323	RPS14	Subtracted	242.238	21.872	264.11
	386		Divided		1.09029
40s ribosomal protein s15 (rig protein). [swissprot;acc:p11174]	219	no value	Subtracted	242.339	24.647	266.986
	304		Divided		1.1017
40s ribosomal protein s15a. [swissprot;acc:p39027]	206	RPS15A	Subtracted	241.411	25.003	266.414

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.