MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Network Comparison Type	description	Hugo	Value Type	Interaction Map	Filtered	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 1 to 50 of 16578 in total

Value Type  : Ranked
Filtered  : 1

Rank	Network Comparison Type	description	Hugo	Interaction Map	red	network_comparison	green
1	Divided	carboxypeptidase d precursor (ec 3.4.17.-) (gp180). [swissprot;acc:o75976]	CPD	Low confidence	16	2	32
		putative glialblastoma cell differentiation-related; putative glialblastoma cell differentiation-related protein. [refseq;acc:nm_016172]	UBAC1	High confidence	10	2.4	24
	Subtracted	homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774]	HLX		215	107	322
		lysosome-associated membrane glycoprotein 1 precursor (lamp-1) (cd107a antigen). [swissprot;acc:p11279]	LAMP1	Low confidence	223		330
2	Divided					1.47982
		mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476]	no value	High confidence	15	1.86667	28
	Subtracted	cell division protein kinase 4 (ec 2.7.1.37) (cyclin-dependent kinase 4) (psk-j3). [swissprot;acc:p11802]	CDK4	Low confidence	223	107	330
		hbs1-like. [refseq;acc:nm_006620]	HBS1L	High confidence	215		322
3	Divided	cell division protein kinase 4 (ec 2.7.1.37) (cyclin-dependent kinase 4) (psk-j3). [swissprot;acc:p11802]	CDK4	Low confidence	223	1.47982	330
		cytohesin 1 (sec7 homolog b2-1). [swissprot;acc:q15438]	PSCD1	High confidence	15	1.86667	28
	Subtracted	cell division protein kinase 6 (ec 2.7.1.37) (serine/threonine protein kinase plstire). [swissprot;acc:q00534]	CDK6	Low confidence	223	107	330
		rad50-interacting protein 1. [refseq;acc:nm_021930]	RINT1	High confidence	337	105	232
4	Divided	cell division protein kinase 6 (ec 2.7.1.37) (serine/threonine protein kinase plstire). [swissprot;acc:q00534]	CDK6	Low confidence	223	1.47982	330
		cytohesin 2 (arf nucleotide-binding site opener) (arno protein) (arf exchange factor). [swissprot;acc:q99418]	PSCD2	High confidence	15	1.86667	28
	Subtracted	lysosome-associated membrane glycoprotein 2 precursor (lamp-2) (cd107b antigen). [swissprot;acc:p13473]	LAMP2	Low confidence	223	107	330
		rho-related btb domain-containing protein 2 (deleted in breast cancer 2 gene protein) (p83). [swissprot;acc:q9byz6]	RHOBTB2	High confidence	337	105	232
5	Divided	cytohesin 4. [swissprot;acc:q9uia0]	PSCD4		15	1.86667	28
		lysosome-associated membrane glycoprotein 2 precursor (lamp-2) (cd107b antigen). [swissprot;acc:p13473]	LAMP2	Low confidence	223	1.47982	330
	Subtracted	oxysterol binding protein-related protein 6 (osbp-related protein 6) (orp-6). [swissprot;acc:q9bzf3]	OSBPL6		318	78	240
		xpa binding protein 1; mbd2 interactor protein; putative atp(gtp)-binding protein. [refseq;acc:nm_007266]	XAB1	High confidence	212	97	309
6	Divided	cytohesin 3 (arf nucleotide-binding site opener 3) (arno3 protein) (general receptor of phosphoinositides 1) (grp1). [swissprot;acc:o43739]	PSCD3		15	1.86667	28
		oxysterol binding protein-related protein 6 (osbp-related protein 6) (orp-6). [swissprot;acc:q9bzf3]	OSBPL6	Low confidence	318	1.325	240
	Subtracted	oxysterol binding protein-related protein 3 (osbp-related protein 3) (orp-3). [swissprot;acc:q9h4l5]	OSBPL3			78
		protein x 0004. [refseq;acc:nm_016301]	ATPBD1C	High confidence	212	97	309
7	Divided	homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774]	HLX		215	1.49767	322
		oxysterol binding protein-related protein 3 (osbp-related protein 3) (orp-3). [swissprot;acc:q9h4l5]	OSBPL3	Low confidence	318	1.325	240
	Subtracted	oxysterol binding protein-related protein 7 (osbp-related protein 7) (orp-7). [swissprot;acc:q9bzf2]	OSBPL7			78
		protein cgi-126 (protein hspc155). [swissprot;acc:q9y3c8]	UFC1	High confidence	288.754	76.2	212.554
8	Divided	hbs1-like. [refseq;acc:nm_006620]	HBS1L		215	1.49767	322
		oxysterol binding protein-related protein 7 (osbp-related protein 7) (orp-7). [swissprot;acc:q9bzf2]	OSBPL7	Low confidence	318	1.325	240
	Subtracted	junctophilin 3 (junctophilin type 3) (jp-3). [swissprot;acc:q8wxh2]	JPH3	High confidence	288	74	362
		thyroid receptor interacting protein 8 (trip-8) (fragment). [swissprot;acc:q15652]	JMJD1C	Low confidence	305.472	58.226	247.246
9	Divided	28s ribosomal protein s17, mitochondrial precursor (mrp-s17) (hspc011). [swissprot;acc:q9y2r5]	MRPS17		58	1.31818	44
		xpa binding protein 1; mbd2 interactor protein; putative atp(gtp)-binding protein. [refseq;acc:nm_007266]	XAB1	High confidence	212	1.45755	309
	Subtracted	gbp protein isoform a. [refseq;acc:nm_017870]	TMEM132A	Low confidence	305.399	58.186	247.213
		junctophilin 2 (junctophilin type 2) (jp-2). [swissprot;acc:q9br39]	JPH2	High confidence	288	74	362
10	Divided	mitochondrial solute carrier protein. [refseq;acc:nm_145305]	SLC25A43	Low confidence	58	1.31818	44
		protein x 0004. [refseq;acc:nm_016301]	ATPBD1C	High confidence	212	1.45755	309
	Subtracted	jumonji domain containing 1; zinc finger protein; testis-specific protein a. [refseq;acc:nm_018433]	JMJD1A	Low confidence	305.303	58.134	247.169
		sphingomyelin phosphodiesterase 2 (ec 3.1.4.12) (neutral sphingomyelinase) (nsmase) (n-smase) (lyso-platelet activating factor- phospholipase c) (lyso-paf-plc). [swissprot;acc:o60906]	SMPD2	High confidence	288	74	362
11	Divided	bestrophin (vitelliform macular dystrophy protein) (tu15b). [swissprot;acc:o76090]	BEST1	Low confidence	37.318	1.30966	28.4944
		rad50-interacting protein 1. [refseq;acc:nm_021930]	RINT1	High confidence	337	1.45259	232
	Subtracted	db83 protein. [swissprot;acc:p57088]	TMEM33		288	74	362
		trypsin iii precursor (ec 3.4.21.4) (brain trypsinogen) (mesotrypsinogen) (trypsin iv). [swissprot;acc:p35030]	PRSS3	Low confidence	304.548	57.724	246.824
12	Divided	rho-related btb domain-containing protein 2 (deleted in breast cancer 2 gene protein) (p83). [swissprot;acc:q9byz6]	RHOBTB2	High confidence	337	1.45259	232
		vitelliform macular dystrophy 2-like protein 2. [refseq;acc:nm_153274]	BEST4	Low confidence	37.3475	1.30933	28.5242
	Subtracted	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-7 subunit. [swissprot;acc:o60262]	no value	High confidence	266.856	69.377	336.233
		trypsin i precursor (ec 3.4.21.4) (cationic trypsinogen). [swissprot;acc:p07477]	PRSS1	Low confidence	304.359	57.622	246.737
13	Divided	nuclear dna-binding protein; small unique nuclear receptor corepressor; c1d dna-binding protein. [refseq;acc:nm_006333]	no value		37.9984	1.30207	29.1831
		protein cgi-126 (protein hspc155). [swissprot;acc:q9y3c8]	UFC1	High confidence	288.754	1.3585	212.554

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.