MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Value Type	Gene	Rank	description	Interaction Map	Network Comparison Type	green	Filtered	red	network_comparison

Results: HTML CSV LaTeX

Showing element 1 to 50 of 29840 in total

Value Type  : Measured
Interaction Map  : High confidence

Rank	description	Network Comparison Type	green	Filtered	red	network_comparison
1	ba508n22.1 (hspc025) (fragment). [sptrembl;acc:q9hcw5]	Subtracted	6410	0	85	6325
	mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476]		33356.5	1	41482.5	8126
	mitochondrial 28s ribosomal protein s32 (s32mt) (mrp-s32) (ptd007) (hspc204). [swissprot;acc:q9y6g3]	Divided	0.00001	0	364	36400000
	rad50-interacting protein 1. [refseq;acc:nm_021930]		2394.5	1	450.5	5.31521
2	cab2. [refseq;acc:nm_033419]		174	0	0.00001	17400000
	cytohesin 1 (sec7 homolog b2-1). [swissprot;acc:q15438]	Subtracted	33356.5	1	41482.5	8126
	lipopolysaccharide-responsive and beige-like anchor protein (cdc4-like protein) (beige-like protein). [swissprot;acc:p50851]		6410	0	85	6325
	rho-related btb domain-containing protein 2 (deleted in breast cancer 2 gene protein) (p83). [swissprot;acc:q9byz6]	Divided	2394.5	1	450.5	5.31521
3	cytohesin 2 (arf nucleotide-binding site opener) (arno protein) (arf exchange factor). [swissprot;acc:q99418]	Subtracted	33356.5		41482.5	8126
	homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774]	Divided	698.5		2597.5	3.71868
	nuclear dna-binding protein; small unique nuclear receptor corepressor; c1d dna-binding protein. [refseq;acc:nm_006333]	Subtracted	19621.3	0	23818.1	4196.8
	pyridoxine 5'-phosphate oxidase. [refseq;acc:nm_018129]	Divided	109		0.00001	10900000
4	cytohesin 4. [swissprot;acc:q9uia0]	Subtracted	33356.5	1	41482.5	8126
	hbs1-like. [refseq;acc:nm_006620]	Divided	698.5		2597.5	3.71868
	homeobox protein hox-c4 (hox-3e) (cp19). [swissprot;acc:p09017]		89	0	0.00001	8900000
	small nuclear ribonucleoprotein e (snrnp-e) (sm protein e) (sm-e) (sme). [swissprot;acc:p08578]	Subtracted	21730		18704	3026
5	cytohesin 3 (arf nucleotide-binding site opener 3) (arno3 protein) (general receptor of phosphoinositides 1) (grp1). [swissprot;acc:o43739]		33356.5	1	41482.5	8126
	histone h4. [swissprot;acc:p02304]		24446.3	0	21773.1	2673.2
	homeobox protein hox-c6 (hox-3c) (hho.c8) (cp25). [swissprot;acc:p09630]	Divided	89		0.00001	8900000
	junctophilin 3 (junctophilin type 3) (jp-3). [swissprot;acc:q8wxh2]		339.5	1	1153.5	3.39764
6	homeobox protein hox-a4 (hox-1d) (hox-1.4). [swissprot;acc:q00056]		89	0	0.00001	8900000
	junctophilin 2 (junctophilin type 2) (jp-2). [swissprot;acc:q9br39]		339.5	1	1153.5	3.39764
	putative glialblastoma cell differentiation-related; putative glialblastoma cell differentiation-related protein. [refseq;acc:nm_016172]	Subtracted	36927.5		44490.5	7563
	similar to zinc finger protein 277. [sptrembl;acc:q8wwa6]		15605.1	0	13174.7	2430.4
7	28s ribosomal protein s17, mitochondrial precursor (mrp-s17) (hspc011). [swissprot;acc:q9y2r5]		28492	1	21185	7307
	sedlin. [swissprot;acc:o14582]	Divided	43	0	0.00001	4300000
	sphingomyelin phosphodiesterase 2 (ec 3.1.4.12) (neutral sphingomyelinase) (nsmase) (n-smase) (lyso-platelet activating factor- phospholipase c) (lyso-paf-plc). [swissprot;acc:o60906]		339.5	1	1153.5	3.39764
	zinc finger protein 277. [swissprot;acc:q9nrm2]	Subtracted	15605.1	0	13174.7	2430.4
8	db83 protein. [swissprot;acc:p57088]	Divided	339.5	1	1153.5	3.39764
	nucleoporin nup43 (p42). [swissprot;acc:q8nfh3]	Subtracted	7500.75	0	5106.93	2393.82
	pantothenate kinase 1 (ec 2.7.1.33) (pantothenic acid kinase 1) (hpank1) (hpank). [swissprot;acc:q8te04]		28492	1	21185	7307
	synbindin (trs23 homolog) (hematopoietic stem/progenitor cell protein 172) (hspc172) (ptd009) (cgi-104). [swissprot;acc:q9y296]	Divided	43	0	0.00001	4300000
9	ataxin 2; olivopontocerebellar ataxia 2, autosomal dominant. [refseq;acc:nm_002973]	Subtracted	14756		12478	2278
	ba508n22.1 (hspc025) (fragment). [sptrembl;acc:q9hcw5]	Divided	6410		85	75.4118
	pantothenate kinase 2, mitochondrial precursor (ec 2.7.1.33) (pantothenic acid kinase 2) (hpank2). [swissprot;acc:q9bz23]	Subtracted	28492	1	21185	7307
	tob2 protein (transducer of erbb-2 2). [swissprot;acc:q14106]	Divided	1281.5		398.5	3.21581
10	lipopolysaccharide-responsive and beige-like anchor protein (cdc4-like protein) (beige-like protein). [swissprot;acc:p50851]		6410	0	85	75.4118
	myosin va (myosin 5a) (dilute myosin heavy chain, non-muscle) (myosin heavy chain 12) (myoxin). [swissprot;acc:q9y4i1]	Subtracted	6193.07		7830.62	1637.55
	pantothenate kinase 3 (ec 2.7.1.33) (pantothenic acid kinase 3) (hpank3). [swissprot;acc:q9h999]		28492	1	21185	7307
	tob1 protein (transducer of erbb-2 1). [swissprot;acc:p50616]	Divided	1281.5		398.5	3.21581
11	cysteine endopeptidase aut-like 2 isoform a; autophagy-related cysteine endopeptidase 2; autophagin 2. [refseq;acc:nm_052936]	Subtracted	7252.02	0	5734.28	1517.74
	dab2 interacting protein; ngap-like protein; doc-2/dab2 interactive protein. [refseq;acc:nm_032552]	Divided	1281.5	1	398.5	3.21581
	mitochondrial solute carrier protein. [refseq;acc:nm_145305]	Subtracted	28492		21185	7307
	serpin b12. [swissprot;acc:q96p63]	Divided	5.56738	0	199.549	35.8425
12	cysteine endopeptidase aut-like isoform b. [refseq;acc:nm_178326]	Subtracted	7099.51		5629.62	1469.89
	cytoplasmic polyadenylation element binding protein 4. [refseq;acc:nm_030627]	Divided	1281.5	1	398.5	3.21581
	hurpin (hacat uv-repressible serpin) (protease inhibitor 13) (headpin) (serpin b13). [swissprot;acc:q9uiv8]		5.71669	0	199.249	34.8539
	nuclear dna-binding protein; small unique nuclear receptor corepressor; c1d dna-binding protein. [refseq;acc:nm_006333]	Subtracted	40795.8	1	34190.9	6604.9
13	adp-ribosylation factor gtpase-activating protein 3 (arf gap 3). [swissprot;acc:q9np61]	Divided	47	0	1363	29
		Subtracted				1316

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.