MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	Rank	Gene	Hugo	Network Comparison Type	Value Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1 to 50 of 16578 in total

Value Type  : Ranked
Filtered  : 1

description	Rank	Hugo	Network Comparison Type	Interaction Map	red	green	network_comparison
1,4-alpha-glucan branching enzyme (ec 2.4.1.18) (glycogen branching enzyme) (brancher enzyme). [swissprot;acc:q04446]	18	GBE1	Divided	High confidence	185.678	245.247	1.32082
	54		Subtracted				59.569
	4130		Divided	Low confidence	199.383	201.5	1.01062
	4141		Subtracted				2.117
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha (ec 2.3.1.51) (1- agp acyltransferase 1) (1-agpat 1) (lysophosphatidic acid acyltransferase-alpha) (lpaat-alpha) (1-acylglycerol-3-phosphate o- acyltransferase 1) (g15 protein). [swissprot;acc:q99943]	1038	no value	Divided	High confidence	186.741	181.041	1.03148
	1120		Subtracted				5.7
	1328		Divided	Low confidence	198.342	194.038	1.02218
	1408		Subtracted				4.304
1-acyl-sn-glycerol-3-phosphate acyltransferase beta (ec 2.3.1.51) (1- agp acyltransferase 2) (1-agpat 2) (lysophosphatidic acid acyltransferase-beta) (lpaat-beta) (1-acylglycerol-3-phosphate o- acyltransferase 2). [swissprot;acc:o15120]	1032	AGPAT2	Divided	High confidence	186.664	180.943	1.03162
	1115		Subtracted				5.721
	1322		Divided	Low confidence	198.322	194.014	1.0222
	1406		Subtracted				4.308
1-acyl-sn-glycerol-3-phosphate acyltransferase delta (ec 2.3.1.51) (1- agp acyltransferase 4) (1-agpat 4) (lysophosphatidic acid acyltransferase-delta) (lpaat-delta) (1-acylglycerol-3-phosphate o- acyltransferase 4). [swissprot;acc:q9nrz5]	588	AGPAT4	Divided		191.507	185.859	1.03039
	664		Subtracted				5.648
	1048		Divided	High confidence	187.96	182.308	1.031
	1128		Subtracted				5.652
1-acyl-sn-glycerol-3-phosphate acyltransferase gamma (ec 2.3.1.51) (1- agp acyltransferase 3) (1-agpat 3) (lysophosphatidic acid acyltransferase-gamma) (lpaat-gamma) (1-acylglycerol-3-phosphate o- acyltransferase 3). [swissprot;acc:q9nrz7]	637	AGPAT3	Divided	Low confidence	192.166	186.751	1.029
	737		Subtracted				5.415
	1043		Divided	High confidence	187.834	182.137	1.03128
	1121		Subtracted				5.697
1-aminocyclopropane-1-carboxylate synthase. [refseq;acc:nm_032592]	3423	no value	Divided	Low confidence	199.702	196.707	1.01523
	3432		Subtracted				2.995
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 (ec 3.1.4.11) (phosphoinositide phospholipase c) (plc-beta-4) (phospholipase c-beta-4). [swissprot;acc:q15147]	3126	PLCB4	Divided	High confidence	0.00001	0.00001	1
			Subtracted		0	0	0
	3567			Low confidence	202.517	199.628	2.889
	3585		Divided				1.01447
10 kda heat shock protein, mitochondrial (hsp10) (10 kda chaperonin) (cpn10). [swissprot;acc:q04984]	1933	HSPE1	Subtracted	High confidence	211.633	213.703	2.07
	1963		Divided				1.00978
	2659			Low confidence	200.053	196.574	1.0177
	2668		Subtracted				3.479
10-formyltetrahydrofolate dehydrogenase (ec 1.5.1.6) (10-fthfdh). [swissprot;acc:o75891]	1795	ALDH1L1			203.414	199.455	3.959
	1873		Divided				1.01985
	2922			High confidence	0.00001	0.00001	1
			Subtracted		0	0	0
130 kda leucine-rich protein (lrp 130) (gp130) (leucine-rich ppr-motif containing protein). [swissprot;acc:p42704]	4255	LRPPRC	Divided	Low confidence	202.306	200.395	1.00954
	4263		Subtracted				1.911
14-3-3 protein beta/alpha (protein kinase c inhibitor protein-1) (kcip-1) (protein 1054). [swissprot;acc:p31946]	2076	YWHAB	Divided		198.587	194.83	1.01928
	2165		Subtracted				3.757
	2421			High confidence	220.681	221.425	0.744
	2439		Divided				1.00337
14-3-3 protein epsilon (mitochondrial import stimulation factor l subunit) (protein kinase c inhibitor protein-1) (kcip-1) (14-3-3e). [swissprot;acc:p42655]	2864	YWHAE		Low confidence	200.418	197.043	1.01713
	2895		Subtracted				3.375
	3088		Divided	High confidence	0.00001	0.00001	1
			Subtracted		0	0	0
14-3-3 protein zeta/delta (protein kinase c inhibitor protein-1) (kcip-1) (factor activating exoenzyme s) (fas). [swissprot;acc:p29312]	2108	YWHAZ	Divided	Low confidence	198.65	194.902	1.01923
	2185		Subtracted				3.748
	2391			High confidence	220.683	221.51	0.827
	2396		Divided				1.00375
14.5 kda translational inhibitor protein (p14.5) (uk114 antigen homolog). [swissprot;acc:p52758]	1035	HRSP12	Subtracted	Low confidence	201.723	196.966	4.757
	1044		Divided				1.02415

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.