MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 994 to 1043 of 12912 in total

Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Value Type	red	green	network_comparison
249	ns1-associated protein 1. [refseq;acc:nm_006372]	Ranked	237.302	212.41	1.11719
	transcription factor iiib 90 kda subunit (tfiiib90) (htfiiib90) (b- related factor 1) (hbrf) (tata box-binding protein-associated factor, rna polymerase iii, subunit 2) (taf3b2). [swissprot;acc:q92994]	Rooted	55.5965	62.9349	1.13199
	tyrosine-protein kinase abl2 (ec 2.7.1.112) (tyrosine kinase arg). [swissprot;acc:p42684]	Measured	6417.18	7859.59	1.22477
250	c-terminal binding protein 2 (ctbp2). [swissprot;acc:p56545]	Squared	69201.8	53013.4	1.30536
	heterogeneous nuclear ribonucleoprotein r (hnrnp r). [swissprot;acc:o43390]	Ranked	237.302	212.41	1.11719
	nucleolar protein family a, member 1; gar1 protein. [refseq;acc:nm_018983]	Rooted	55.5965	62.9349	1.13199
	proto-oncogene tyrosine-protein kinase src (ec 2.7.1.112) (p60-src) (c-src). [swissprot;acc:p12931]	Measured	6417.18	7859.6	1.22477
251	b-cell cll/lymphoma 6, member b (zinc finger protein); zinc finger protein 62. [refseq;acc:nm_181844]	Squared	69165.6	52992.1	1.30521
	max protein. [swissprot;acc:p25912]	Rooted	56.3054	63.7148	1.13159
	oligopeptide transporter, small intestine isoform (peptide transporter 1) (intestinal h+/peptide cotransporter) (solute carrier family 15, member 1). [swissprot;acc:p46059]	Ranked	186.172	166.661	1.11707
	tyrosine-protein kinase hck (ec 2.7.1.112) (p59-hck/p60-hck) (hemopoietic cell kinase). [swissprot;acc:p08631]	Measured	6417.18	7859.6	1.22477
252	crk-like protein. [swissprot;acc:p46109]
	eukaryotic translation initiation factor 4 gamma (eif-4-gamma) (eif- 4g) (eif4g) (p220). [swissprot;acc:q04637]	Ranked	237.292	212.457	1.11689
	nuclear transcription factor y subunit beta (nf-y protein chain b) (nf-yb) (ccaat-binding transcription factor subunit a) (cbf-a) (caat- box dna binding protein subunit b). [swissprot;acc:p25208]	Rooted	51.6736	58.4422	1.13099
	pas domain containing serine/threonine kinase; pas-serine/threonine kinase. [refseq;acc:nm_015148]	Squared	69165	52991.7	1.3052
253	b-cell lymphoma 6 protein (bcl-6) (zinc finger protein 51) (laz-3 protein) (bcl-5). [swissprot;acc:p41182]
	mad protein (max dimerizer). [swissprot;acc:q05195]	Ranked	228	204.333	1.11583
	proto-oncogene tyrosine-protein kinase abl1 (ec 2.7.1.112) (p150) (c-abl). [swissprot;acc:p00519]	Measured	6417.18	7859.59	1.22477
	signal recognition particle 9 kda protein (srp9). [swissprot;acc:p49458]	Rooted	53.5956	60.465	1.12817
254	proto-oncogene tyrosine-protein kinase fyn (ec 2.7.1.112) (p59-fyn) (syn) (slk). [swissprot;acc:p06241]	Measured	6417.18	7859.6	1.22477
	signal recognition particle 9 kda protein (srp9). [swissprot;acc:p49458]	Rooted	53.607	60.4452	1.12756
	source of immunodominant mhc-associated peptides; homolog of yeast stt3 gene. [refseq;acc:nm_178862]	Ranked	200.691	179.88	1.11569
	zinc finger protein slug (neural crest transcription factor slug) (snail homolog 2). [swissprot;acc:o43623]	Squared	69165	52991.7	1.3052
255	c-terminal binding protein 1 (ctbp1). [swissprot;acc:q13363]		69123.3	52967	1.30503
	oligosaccharyl transferase stt3 subunit homolog (b5) (integral membrane protein 1) (tmc). [swissprot;acc:p46977]	Ranked	200.691	179.88	1.11569
	proto-oncogene tyrosine-protein kinase fgr (ec 2.7.1.112) (p55-fgr) (c-fgr). [swissprot;acc:p09769]	Measured	6417.18	7859.6	1.22477
	ribonucleoside-diphosphate reductase m2 chain (ec 1.17.4.1) (ribonucleotide reductase small chain). [swissprot;acc:p31350]	Rooted	62.9007	70.8854	1.12694
256	ccaat-box-binding transcription factor (ccaat-binding factor) (cbf). [swissprot;acc:q03701]		48.0045	54.0843	1.12665
	formin binding protein 3; fas-ligand associated factor 1; huntingtin-interacting protein a; ny-ren-6 antigen. [refseq;acc:nm_017892]	Squared	15465.1	20151	1.303
	grb2-related adaptor protein 2 (gads protein) (growth factor receptor binding protein) (grblg) (grf40 adaptor protein) (grf-40) (grb-2-like protein) (grb2l) (grbx) (p38) (hematopoietic cell-associated adaptor protein grpl) (adapter protein grid) (sh3-sh2-sh3 adaptor mona). [swissprot;acc:o75791]	Measured	6417.19	7859.51	1.22476
	max interacting protein 1 (mxi1 protein). [swissprot;acc:p50539]	Ranked	227.999	204.357	1.11569
257	cartilage oligomeric matrix protein precursor (comp). [swissprot;acc:p49747]	Rooted	51.6125	45.8409	1.12591
	ccaat displacement protein (cdp) (cut-like 1). [swissprot;acc:p39880]	Measured	6417.31	7858.12	1.22452
	dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kda subunit precursor (ec 2.4.1.119) (oligosaccharyl transferase 48 kda subunit) (ddost 48 kda subunit). [swissprot;acc:p39656]	Ranked	200.691	179.88	1.11569
	huntingtin-interacting protein hypa/fbp11 (fragment). [sptrembl;acc:o75404]	Squared	15482.3	20162.4	1.30229
258	homeobox protein cux-2 (cut-like 2) (fragment). [swissprot;acc:o14529]	Measured	6417.33	7857.93	1.22449
	huntingtin interacting protein 1 (hip-i). [swissprot;acc:o00291]	Squared	76438	58889.7	1.29799
	max-interacting transcriptional repressor mad4 (max-associated protein 4) (max dimerization protein 4). [swissprot;acc:q14582]	Ranked	227.999	204.366	1.11564
	thrombospondin 3 precursor. [swissprot;acc:p49746]	Rooted	51.6132	45.8422	1.12589
259	goodpasture antigen-binding protein (ec 2.7.1.37) (gpbp) (collagen type iv alpha 3 binding protein) (star-related lipid transfer protein 11) (stard11) (start domain-containing protein 11). [swissprot;acc:q9y5p4]	Squared	76360.8	58841.7	1.29773
	max dimerization protein 3; likely ortholog of mouse max dimerization protein 3. [refseq;acc:nm_031300]	Ranked	227.999	204.37	1.11562
	neural wiskott-aldrich syndrome protein (n-wasp). [swissprot;acc:o00401]	Measured	6417.81	7852.52	1.22355
	tuftelin-interacting protein 11 (hspc006). [swissprot;acc:q9ubb9]	Rooted	58.2964	65.5926	1.12516
260	c439a6.1 (novel protein similar to heparan sulfate (glucosamine) 3-o- sulfotransferases) (fragment). [sptrembl;acc:q96qi5]	Ranked	219.421	196.978	1.11394
	huntingtin interacting protein 1 related (hip1-related) (hip 12). [swissprot;acc:o75146]	Squared	76296.4	58801.6	1.29752
	multisynthetase complex auxiliary component p43 [contains: endothelial-monocyte activating polypeptide ii (emap-ii) (small inducible cytokine subfamily e member 1)]. [swissprot;acc:q12904]	Rooted	59.0951	66.4332	1.12417
	signal recognition particle 9 kda protein (srp9). [swissprot;acc:p49458]	Measured	4244.95	5193.42	1.22343
261	heparan sulfate d-glucosaminyl 3-o-sulfotransferase 3a1; heparin-glucosamine 3-o-sulfotransferase. [refseq;acc:nm_006042]	Ranked	219.421	196.978	1.11394
	pyruvate carboxylase, mitochondrial precursor (ec 6.4.1.1) (pyruvic carboxylase) (pcb). [swissprot;acc:p11498]	Squared	48127.9	62245.6	1.29334
	ribonucleotide reductase m2 b (tp53 inducible); p53-inducible ribonucleotide reductase small subunit 2 homolog. [refseq;acc:nm_015713]	Rooted	62.3337	70.0738	1.12417

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.