MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Network Comparison Type	Filtered	Rank	network_comparison	red	green	Interaction Map	description	Gene	Value Type

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Showing element 1 to 50 of 3228 in total

Network Comparison Type  : Divided
Filtered  : 1
Interaction Map  : High confidence
Value Type  : Measured

Rank	network_comparison	red	green	description
1	5.31521	450.5	2394.5	rad50-interacting protein 1. [refseq;acc:nm_021930]
2				rho-related btb domain-containing protein 2 (deleted in breast cancer 2 gene protein) (p83). [swissprot;acc:q9byz6]
3	3.71868	2597.5	698.5	homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774]
4				hbs1-like. [refseq;acc:nm_006620]
5	3.39764	1153.5	339.5	junctophilin 3 (junctophilin type 3) (jp-3). [swissprot;acc:q8wxh2]
6				junctophilin 2 (junctophilin type 2) (jp-2). [swissprot;acc:q9br39]
7				sphingomyelin phosphodiesterase 2 (ec 3.1.4.12) (neutral sphingomyelinase) (nsmase) (n-smase) (lyso-platelet activating factor- phospholipase c) (lyso-paf-plc). [swissprot;acc:o60906]
8				db83 protein. [swissprot;acc:p57088]
9	3.21581	398.5	1281.5	tob2 protein (transducer of erbb-2 2). [swissprot;acc:q14106]
10				tob1 protein (transducer of erbb-2 1). [swissprot;acc:p50616]
11				dab2 interacting protein; ngap-like protein; doc-2/dab2 interactive protein. [refseq;acc:nm_032552]
12				cytoplasmic polyadenylation element binding protein 4. [refseq;acc:nm_030627]
13				cytoplasmic polyadenylation element binding protein 3. [refseq;acc:nm_014912]
14				ras gtpase-activating protein ngap (ras protein activator like 1). [swissprot;acc:q9ujf2]
15	3.06659	2671	871	xpa binding protein 1; mbd2 interactor protein; putative atp(gtp)-binding protein. [refseq;acc:nm_007266]
16				protein x 0004. [refseq;acc:nm_016301]
17	2.96739	460	1365	dgcr14 protein (digeorge syndrome critical region 14) (es2 protein). [swissprot;acc:q96df8]
18	2.75351	677.5	1865.5	protein phosphatase 1, regulatory (inhibitor) subunit 14a; 17-kda pkc-potentiated inhibitory protein of pp1. [refseq;acc:nm_033256]
19				microfibril-associated glycoprotein 4 precursor. [swissprot;acc:p55083]
20				protein phosphatase 1, regulatory subunit 14d; pkc-dependent pp1 inhibitory protein. [refseq;acc:nm_017726]
21				ficolin 2 precursor (collagen/fibrinogen domain-containing protein 2) (ficolin-b) (ficolin b) (serum lectin p35) (ebp-37) (hucolin) (l- ficolin). [swissprot;acc:q15485]
22				protein phosphatase 1, regulatory (inhibitor) subunit 14c; serologically defined breast cancer antigen ny-br-81; pkc-potentiated pp1 inhibitory protein. [refseq;acc:nm_030949]
23	2.7072	699.76	1894.39	gbp protein isoform a. [refseq;acc:nm_017870]
24	2.21818	950.561	2108.52	protein kinase, interferon-inducible double stranded rna dependent activator; protein activator of the interferon-induced protein kinase. [refseq;acc:nm_003690]
25	2.0534	1833.01	892.67	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-7 subunit. [swissprot;acc:o60262]
26				guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-12 subunit. [swissprot;acc:q9ubi6]
27	2.04922	1834.33	895.134	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-4 subunit. [swissprot;acc:p50150]
28	2.04912	1834.36	895.194	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-3 subunit. [swissprot;acc:p29798]
29	2.04858	1834.52	895.507	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-8 subunit (gamma-9). [swissprot;acc:q9uk08]
30	2.04837	1834.59	895.633	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 subunit. [swissprot;acc:p30670]
31	2.04827	1834.63	895.697	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-10 subunit. [swissprot;acc:p50151]
32	2.04793	1834.73	895.893	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 like subunit. [swissprot;acc:q9y3k8]
33	2.04611	1835.3	896.972	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-11 subunit. [swissprot;acc:p50152]
34	2.02382	1836.71	907.546	guanine nucleotide-binding protein g(y), alpha subunit (alpha-11). [swissprot;acc:p29992]
35	2.02378		907.564	guanine nucleotide-binding protein g(q), alpha subunit. [swissprot;acc:p50148]
36	2.02344	1836.76	907.741	guanine nucleotide-binding protein g(z), alpha subunit (g(x) alpha chain) (gz-alpha). [swissprot;acc:p19086]
37	2.02339		907.763	guanine nucleotide-binding protein g(t), alpha-1 subunit (transducin alpha-1 chain). [swissprot;acc:p11488]
38	2.02337		907.774	guanine nucleotide-binding protein g(t), alpha-2 subunit (transducin alpha-2 chain). [swissprot;acc:p19087]
39	2.02312	1836.8	907.903	guanine nucleotide-binding protein g(i), alpha-2 subunit (adenylate cyclase-inhibiting g alpha protein). [swissprot;acc:p04899]
40	2.02297	1836.81	907.978	guanine nucleotide-binding protein g(i), alpha-1 subunit (adenylate cyclase-inhibiting g alpha protein). [swissprot;acc:p04898]
41				guanine nucleotide-binding protein g(k), alpha subunit (g(i) alpha-3). [swissprot;acc:p08754]
42	1.93827	1857.32	958.237	guanine nucleotide-binding protein beta subunit 5 (transducin beta chain 5). [swissprot;acc:o14775]
43	1.83093	1881.02	1027.36	guanine nucleotide-binding protein g(i)/g(s)/g(t) beta subunit 3 (transducin beta chain 3). [swissprot;acc:p16520]
44	1.82652	1931.34	1057.39	guanine nucleotide-binding protein g(i)/g(s)/g(t) beta subunit 1 (transducin beta chain 1). [swissprot;acc:p04901]
45	1.82448	1926.69	1056.02	guanine nucleotide-binding protein beta subunit 4 (transducin beta chain 4). [swissprot;acc:q9hav0]
46	1.78438	779.167	1390.33	neurogenic differentiation factor 2 (neurod2). [swissprot;acc:q15784]
47				chromodomain helicase-dna-binding protein 3 (chd-3) (mi-2 autoantigen 240 kda protein) (mi2-alpha). [swissprot;acc:q12873]
48				doc-1 related protein (doc-1r). [swissprot;acc:o75956]
49				neurogenic differentiation factor 6 (neurod6) (my051 protein). [swissprot;acc:q96nk8]
50				neurogenic differentiation factor 1 (neurod1) (neurod). [swissprot;acc:q13562]

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.