MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Network Comparison Type	network_comparison	Gene	Value Type	description	Interaction Map	red	Hugo	Filtered	green

Results: HTML CSV LaTeX

Showing element 1 to 50 of 3228 in total

Network Comparison Type  : Divided
Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	network_comparison	description	red	Hugo	green
1	2.4	putative glialblastoma cell differentiation-related; putative glialblastoma cell differentiation-related protein. [refseq;acc:nm_016172]	10	UBAC1	24
2	1.86667	mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476]	15	no value	28
3		cytohesin 1 (sec7 homolog b2-1). [swissprot;acc:q15438]		PSCD1
4		cytohesin 2 (arf nucleotide-binding site opener) (arno protein) (arf exchange factor). [swissprot;acc:q99418]		PSCD2
5		cytohesin 4. [swissprot;acc:q9uia0]		PSCD4
6		cytohesin 3 (arf nucleotide-binding site opener 3) (arno3 protein) (general receptor of phosphoinositides 1) (grp1). [swissprot;acc:o43739]		PSCD3
7	1.49767	homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774]	215	HLX	322
8		hbs1-like. [refseq;acc:nm_006620]		HBS1L
9	1.45755	xpa binding protein 1; mbd2 interactor protein; putative atp(gtp)-binding protein. [refseq;acc:nm_007266]	212	XAB1	309
10		protein x 0004. [refseq;acc:nm_016301]		ATPBD1C
11	1.45259	rad50-interacting protein 1. [refseq;acc:nm_021930]	337	RINT1	232
12		rho-related btb domain-containing protein 2 (deleted in breast cancer 2 gene protein) (p83). [swissprot;acc:q9byz6]		RHOBTB2
13	1.3585	protein cgi-126 (protein hspc155). [swissprot;acc:q9y3c8]	288.754	UFC1	212.554
14	1.32952	cysteine endopeptidase aut-like 2 isoform a; autophagy-related cysteine endopeptidase 2; autophagin 2. [refseq;acc:nm_052936]	56.6768	ATG4A	75.3531
15	1.32914	microtubule-associated proteins 1a/1b light chain 3b (map1a/map1b lc3 b) (map1a/1b light chain 3 b). [swissprot;acc:q9gzq8]	56.7244	MAP1LC3B	75.3948
16	1.32913	microtubule-associated proteins 1a/1b light chain 3a (map1a/map1b lc3 a) (map1a/1b light chain 3 a). [swissprot;acc:q9h492]	56.7252	MAP1LC3A	75.3954
17	1.32866	cysteine endopeptidase aut-like isoform b. [refseq;acc:nm_178326]	56.7841	ATG4B	75.447
18	1.32082	1,4-alpha-glucan branching enzyme (ec 2.4.1.18) (glycogen branching enzyme) (brancher enzyme). [swissprot;acc:q04446]	185.678	GBE1	245.247
19		glycogen phosphorylase, brain form (ec 2.4.1.1). [swissprot;acc:p11216]		PYGB
20		glycogen phosphorylase, liver form (ec 2.4.1.1). [swissprot;acc:p06737]		PYGL
21		myosin xv (unconventional myosin-15). [swissprot;acc:q9ukn7]		MYO15A
22		glycogen phosphorylase, muscle form (ec 2.4.1.1) (myophosphorylase). [swissprot;acc:p11217]		PYGM
23	1.31818	28s ribosomal protein s17, mitochondrial precursor (mrp-s17) (hspc011). [swissprot;acc:q9y2r5]	58	MRPS17	44
24		pantothenate kinase 1 (ec 2.7.1.33) (pantothenic acid kinase 1) (hpank1) (hpank). [swissprot;acc:q8te04]		PANK1
25		pantothenate kinase 2, mitochondrial precursor (ec 2.7.1.33) (pantothenic acid kinase 2) (hpank2). [swissprot;acc:q9bz23]		PANK2
26		pantothenate kinase 3 (ec 2.7.1.33) (pantothenic acid kinase 3) (hpank3). [swissprot;acc:q9h999]		PANK3
27		mitochondrial solute carrier protein. [refseq;acc:nm_145305]		SLC25A43
28	1.31416	cyclic-amp-dependent transcription factor atf-3 (activating transcription factor 3). [swissprot;acc:p18847]	201.949	ATF3	153.671
29	1.29991	uncharacterized hematopoietic stem/progenitor cells protein mds026. [sptrembl;acc:q9nz48]	187.458	PPP2R2D	243.678
30		serine/threonine protein phosphatase 2a, 55 kda regulatory subunit b, alpha isoform (pp2a, subunit b, b-alpha isoform) (pp2a, subunit b, b55-alpha isoform) (pp2a, subunit b, pr55-alpha isoform) (pp2a, subunit b, r2-alpha isoform). [swissprot;acc:q00007]	187.457	no value
31	1.2999	serine/threonine protein phosphatase 2a, 55 kda regulatory subunit b, beta isoform (pp2a, subunit b, b-beta isoform) (pp2a, subunit b, b55- beta isoform) (pp2a, subunit b, pr55-beta isoform) (pp2a, subunit b, r2-beta isoform). [swissprot;acc:q00005]	187.458	PPP2R2B	243.677
32	1.29985	serine/threonine protein phosphatase 2a, 55 kda regulatory subunit b, gamma isoform (pp2a, subunit b, b-gamma isoform) (pp2a, subunit b, b55-gamma isoform) (pp2a, subunit b, pr55-gamma isoform) (pp2a, subunit b, r2-gamma isoform) (imypno1). [swissprot;acc:q9y2t4]	187.462	PPP2R2C	243.673
33	1.28647	serine/threonine protein phosphatase 2a, 65 kda regulatory subunit a, beta isoform (pp2a, subunit a, pr65-beta isoform) (pp2a, subunit a, r1-beta isoform). [swissprot;acc:p30154]	188.688	PPP2R1B	242.742
34	1.28235	serine/threonine protein phosphatase 2a, 65 kda regulatory subunit a, alpha isoform (pp2a, subunit a, pr65-alpha isoform) (pp2a, subunit a, r1-alpha isoform) (medium tumor antigen-associated 61 kda protein). [swissprot;acc:p30153]	189.07	PPP2R1A	242.453
35	1.27519	nuclear transcription factor y subunit gamma (nf-y protein chain c) (nuclear factor yc) (nf-yc) (ccaat-binding transcription factor subunit c) (cbf-c) (transactivator hsm-1/2). [swissprot;acc:q13952]	260.532	NFYC	204.309
36		ccaat-binding transcription factor subunit b (cbf-b) (nf-y protein chain a) (nf-ya) (caat-box dna binding protein subunit a). [swissprot;acc:p23511]		NFYA
37	1.27273	protein phosphatase 1, regulatory (inhibitor) subunit 14a; 17-kda pkc-potentiated inhibitory protein of pp1. [refseq;acc:nm_033256]	322	PPP1R14A	253
38		microfibril-associated glycoprotein 4 precursor. [swissprot;acc:p55083]		MFAP4
39		protein phosphatase 1, regulatory subunit 14d; pkc-dependent pp1 inhibitory protein. [refseq;acc:nm_017726]		PPP1R14D
40		ficolin 2 precursor (collagen/fibrinogen domain-containing protein 2) (ficolin-b) (ficolin b) (serum lectin p35) (ebp-37) (hucolin) (l- ficolin). [swissprot;acc:q15485]		FCN2
41		protein phosphatase 1, regulatory (inhibitor) subunit 14c; serologically defined breast cancer antigen ny-br-81; pkc-potentiated pp1 inhibitory protein. [refseq;acc:nm_030949]		no value
42	1.2714	proto-oncogene protein c-fos (cellular oncogene fos) (g0/g1 switch regulatory protein 7). [swissprot;acc:p01100]	204.641	FOS	160.957
43		jun dimerization protein. [refseq;acc:nm_130469]		no value
44	1.2707	fos-related antigen 2. [swissprot;acc:p15408]		FOSL2	161.046
45	1.27066	protein fosb (g0/g1 switch regulatory protein 3). [swissprot;acc:p53539]		FOSB	161.051
46	1.27053	fos-related antigen 1 (fra-1). [swissprot;acc:p15407]	204.642	FOSL1	161.068
47	1.26938	gbp protein isoform a. [refseq;acc:nm_017870]	325.586	TMEM132A	256.492
48	1.26868	gaba(a) receptor-associated protein; gaba(a)-receptor-associated protein. [refseq;acc:nm_007278]	65.4586	GABARAP	83.0461
49	1.26667	beta-arrestin 2 (arrestin, beta 2). [swissprot;acc:p32121]	133	ARRB2	105
50		beta-arrestin 1 (arrestin, beta 1). [swissprot;acc:p49407]		ARRB1

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.