MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Value Type	Network Comparison Type	Filtered	Interaction Map	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 501 to 550 of 3730 in total

Value Type  : Measured
Network Comparison Type  : Divided
Interaction Map  : High confidence

Rank	description	Filtered	red	network_comparison	green
251	keratin associated protein 4-12; keratin associated protein 4.12. [refseq;acc:nm_031854]	0	1225.08	1.13498	1079.38
	tyrosine-protein kinase hck (ec 2.7.1.112) (p59-hck/p60-hck) (hemopoietic cell kinase). [swissprot;acc:p08631]	1	6417.18	1.22477	7859.6
252	crk-like protein. [swissprot;acc:p46109]
	star-related lipid transfer protein 6 (stard6) (start domain- containing protein 6). [swissprot;acc:p59095]	0	1225.08	1.13498	1079.38
253	espin. [refseq;acc:nm_031475]		1225.07
	proto-oncogene tyrosine-protein kinase abl1 (ec 2.7.1.112) (p150) (c-abl). [swissprot;acc:p00519]	1	6417.18	1.22477	7859.59
254	40s ribosomal protein s4, y isoform 2. [swissprot;acc:q8td47]	0	1318.22	1.13461	1495.66
	proto-oncogene tyrosine-protein kinase fyn (ec 2.7.1.112) (p59-fyn) (syn) (slk). [swissprot;acc:p06241]	1	6417.18	1.22477	7859.6
255	40s ribosomal protein s4, x isoform (single copy abundant mrna protein) (scr10). [swissprot;acc:p12750]	0	1317.84	1.1346	1495.22
	proto-oncogene tyrosine-protein kinase fgr (ec 2.7.1.112) (p55-fgr) (c-fgr). [swissprot;acc:p09769]	1	6417.18	1.22477	7859.6
256	grb2-related adaptor protein 2 (gads protein) (growth factor receptor binding protein) (grblg) (grf40 adaptor protein) (grf-40) (grb-2-like protein) (grb2l) (grbx) (p38) (hematopoietic cell-associated adaptor protein grpl) (adapter protein grid) (sh3-sh2-sh3 adaptor mona). [swissprot;acc:o75791]		6417.19	1.22476	7859.51
	keratin associated protein 9-4; keratin associated protein 9.4. [refseq;acc:nm_033191]	0	1224.65	1.13418	1079.77
257	ccaat displacement protein (cdp) (cut-like 1). [swissprot;acc:p39880]	1	6417.31	1.22452	7858.12
	creatine kinase, ubiquitous mitochondrial precursor (ec 2.7.3.2) (u- mtck) (mia-ck) (acidic-type mitochondrial creatine kinase). [swissprot;acc:p12532]	0	861.401	1.13358	759.896
258	40s ribosomal protein s15 (rig protein). [swissprot;acc:p11174]		1183.16	1.13048	1337.54
	homeobox protein cux-2 (cut-like 2) (fragment). [swissprot;acc:o14529]	1	6417.33	1.22449	7857.93
259	60s ribosomal protein l23a. [swissprot;acc:p29316]	0	1295.49	1.1297	1463.51
	neural wiskott-aldrich syndrome protein (n-wasp). [swissprot;acc:o00401]	1	6417.81	1.22355	7852.52
260	signal recognition particle 9 kda protein (srp9). [swissprot;acc:p49458]		4244.95	1.22343	5193.42
	voltage-dependent calcium channel gamma-5 subunit (neuronal voltage- gated calcium channel gamma-5 subunit). [swissprot;acc:q9uf02]	0	1949.36	1.1296	2202
261	c367g8.3 (novel protein similar to rpl23a (60s ribosomal protein l23a)) (60s ribosomal protein l23a like). [sptrembl;acc:q9br02]		1295.81	1.12945	1463.55
	signal recognition particle 9 kda protein (srp9). [swissprot;acc:p49458]	1	4247.36	1.22255	5192.61
262	adenylyl cyclase-associated protein 2 (cap 2). [swissprot;acc:p40123]	0	764.479	1.12926	676.971
	cleavage and polyadenylation specific factor 4, 30kd subunit; cleavage-polyadenylation specificity factor, 30kd; no arches-like (zebrafish) zinc finger protein; cleavage-polyadenylation specificity factor. [refseq;acc:nm_006693]	1	24896.4	1.21852	20431.7
263	sirtuin 7; sir2-related protein type 7; sirtuin type 7; sirtuin (silent mating type information regulation 2, s.cerevisiae, homolog) 7; silent mating type information regulation 2, s.cerevisiae, homolog 7; sirtuin silent mating type information regulation 2 homolog 7 (s. cerevisiae). [refseq;acc:nm_016538]	0	1843	1.1286	1633
	trs85 homolog. [swissprot;acc:q9y2l5]	1	24896.4	1.21852	20431.7
264	cop9 constitutive photomorphogenic homolog subunit 3; cop9 complex subunit 3; jab1-containing signalosome subunit 3. [refseq;acc:nm_003653]		4987.58	1.2181	4094.57
	sodium/potassium-transporting atpase alpha-2 chain precursor (ec 3.6.3.9) (sodium pump 2) (na+/k+ atpase 2). [swissprot;acc:p50993]	0	3336.48	1.12829	2957.12
265	60s ribosomal protein l9. [swissprot;acc:p32969]		1685.44	1.12375	1894.01
	wd-repeat protein wdc146. [swissprot;acc:q9c0j8]	1	24806.9	1.21782	20369.9
266	aldehyde dehydrogenase 8 (ec 1.2.1.5). [swissprot;acc:p48448]	0	1475.05	1.1235	1312.91
	cleavage and polyadenylation specificity factor, 160 kda subunit (cpsf 160 kda subunit). [swissprot;acc:q10570]	1	24806.9	1.21782	20369.9
267	ral guanine nucleotide dissociation stimulator (ralgef) (ralgds). [swissprot;acc:q12967]		14021.4	1.21682	11523
	uncharacterized bone marrow protein bm033. [refseq;acc:nm_018452]	0	1475.05	1.1235	1312.91
268	cleavage and polyadenylation specificity factor, 100 kda subunit (cpsf 100 kda subunit) (fragment). [swissprot;acc:q9p2i0]	1	24473.9	1.21593	20127.8
	far upstream element-binding protein; far upstream element binding protein; fuse-binding protein. [refseq;acc:nm_003902]	0	604.529	1.12346	538.094
269	60s ribosomal protein l10 (qm protein) (tumor suppressor qm) (laminin receptor homolog). [swissprot;acc:p27635]		1217.92	1.12309	1367.83
	u6 snrna-associated sm-like protein lsm8. [swissprot;acc:o95777]	1	4590.18	1.21466	5575.52
270	fip1-like 1; rearranged in hypereosinophilia. [refseq;acc:nm_030917]		23640.2	1.21358	19479.8
	ribosomal protein l10-like protein. [refseq;acc:nm_080746]	0	1217.96	1.12309	1367.88
271	chromatin accessibility complex protein 1 (chrac-1) (chrac-15) (huchrac15) (dna polymerase epsilon subunit p15). [swissprot;acc:q9nrg0]	1	2554.89	1.21092	3093.78
	histone h4. [swissprot;acc:p02304]	0	21773.1	1.12278	24446.3
272	60s ribosomal protein l15. [swissprot;acc:p39030]		846.216	1.12261	753.793
	histone acetyltransferase type b catalytic subunit (ec 2.3.1.48). [swissprot;acc:o14929]	1	3858.52	1.21012	4669.27
273	eukaryotic translation initiation factor 5 (eif-5). [swissprot;acc:p55010]		3199.4	1.20985	3870.8
	sorcin (22 kda protein) (cp-22) (v19). [swissprot;acc:p30626]	0	1410.81	1.1218	1582.65
274	brain protein 16. [refseq;acc:nm_016458]		2155.75	1.12172	2418.14
	chromosome 3p21.1 gene sequence. [refseq;acc:nm_013286]	1	3119.98	1.20953	2579.49
275	regulator of g-protein signaling 19 (rgs19) (g-alpha interacting protein) (gaip protein). [swissprot;acc:p49795]
	swi/snf-related matrix-associated actin-dependent regulator of chromatin c2 isoform a; mammalian chromatin remodeling complex brg1-associated factor 170; chromatin remodeling complex baf170 subunit; swi3-like protein; swi/snf complex 170 kda subunit. [refseq;acc:nm_003075]	0	717.401	1.12172	804.725

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.