MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Network Comparison Type	Rank	Gene	Hugo	description	Value Type	Interaction Map	Filtered	network_comparison	red	green

Results: HTML CSV LaTeX

Showing element 162 to 211 of 1892 in total

Network Comparison Type  : Subtracted
Interaction Map  : High confidence
Filtered  : 1
network_comparison  : 0
red  : 0
green  : 0

Rank	Hugo	description	Value Type
2796	DMAP1	dna methyltransferase 1-associated protein 1 (dnmt1-associated protein 1) (dnmap1). [swissprot;acc:q9npf5]	Ranked
			Squared
			Rooted
2797	ODF3	sperm tail protein shippo1; h-shippo 1. [refseq;acc:nm_053280]	Measured
			Ranked
			Squared
			Rooted
2798	ARIH2	ariadne-2 protein homolog (ari-2) (triad1 protein) (ht005). [swissprot;acc:o95376]	Measured
			Ranked
			Squared
			Rooted
2799	HMGB4	hmg2 like. [refseq;acc:nm_145205]	Measured
			Ranked
			Squared
			Rooted
2800	MLXIP	mondoa. [refseq;acc:nm_014938]	Measured
			Ranked
			Squared
			Rooted
2801	ERCC4	dna-repair protein complementing xp-f cell (xeroderma pigmentosum group f complementing protein) (dna excision repair protein ercc-4). [swissprot;acc:q92889]	Measured
			Ranked
			Squared
			Rooted
2802	no value	3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase type i (3beta-hsd i) (trophoblast antigen fdo161g) [includes: 3-beta-hydroxy- delta(5)-steroid dehydrogenase (ec 1.1.1.145) (3-beta-hydroxy-5-ene steroid dehydrogenase) (progesterone reductase); steroid delta- isomerase (ec 5.3.3.1) (delta-5-3-ketosteroid isomerase)]. [swissprot;acc:p14060]	Measured
			Ranked
			Squared
			Rooted
2803		nanos (fragment). [sptrembl;acc:q8wy41]	Measured
			Ranked
			Squared
			Rooted
2804	BANF1	barrier-to-autointegration factor (breakpoint cluster region protein 1). [swissprot;acc:o75531]	Measured
			Ranked
			Squared
			Rooted
2805	PACS1	phosphofurin acidic cluster sorting protein 1 isoform 1; cytosolic sorting protein pacs-1. [refseq;acc:nm_018026]	Measured
			Ranked
			Squared
			Rooted
2806	SPSB4	spry domain-containing socs box protein ssb-4. [refseq;acc:nm_080862]	Measured
			Ranked
			Squared
			Rooted
2807	RAB1C	ras-related protein rab-1b. [swissprot;acc:q9h0u4]	Measured
			Ranked
			Squared
			Rooted
2808	LIG4	dna ligase iv (ec 6.5.1.1) (polydeoxyribonucleotide synthase [atp]). [swissprot;acc:p49917]	Measured
			Ranked
			Squared

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.