MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Value Type	Network Comparison Type	Filtered	Interaction Map	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 2601 to 2650 of 8289 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Filtered  : 1

Rank	description	Interaction Map	red	green	network_comparison
1301	tumor protein d54 (hd54) (d52-like 2). [swissprot;acc:o43399]	High confidence	206.852	211.757	1.02371
	tyrosine-protein kinase hck (ec 2.7.1.112) (p59-hck/p60-hck) (hemopoietic cell kinase). [swissprot;acc:p08631]	Low confidence	199.276	194.918	1.02236
1302	proto-oncogene tyrosine-protein kinase fyn (ec 2.7.1.112) (p59-fyn) (syn) (slk). [swissprot;acc:p06241]
	ubiquinol-cytochrome c reductase complex core protein i, mitochondrial precursor (ec 1.10.2.2). [swissprot;acc:p31930]	High confidence	217.624	212.584	1.02371
1303	activator of camp-responsive element modulator (crem) in testis; lim protein act. [refseq;acc:nm_020482]		269.157	275.531	1.02368
	proto-oncogene tyrosine-protein kinase fgr (ec 2.7.1.112) (p55-fgr) (c-fgr). [swissprot;acc:p09769]	Low confidence	199.276	194.918	1.02236
1304	glutathione reductase, mitochondrial precursor (ec 1.8.1.7) (gr) (grase). [swissprot;acc:p00390]	High confidence	207.387	212.275	1.02357
	tyrosine-protein kinase abl2 (ec 2.7.1.112) (tyrosine kinase arg). [swissprot;acc:p42684]	Low confidence	199.275	194.918	1.02235
1305	glycerol-3-phosphate acyltransferase, mitochondrial precursor (ec 2.3.1.15) (gpat). [swissprot;acc:q9hcl2]		204.064	199.602
	serine/threonine protein phosphatase 2b catalytic subunit, alpha isoform (ec 3.1.3.16) (calmodulin-dependent calcineurin a subunit, alpha isoform) (cam-prp catalytic subunit). [swissprot;acc:q08209]	High confidence	218.439	213.436	1.02344
1306	proto-oncogene tyrosine-protein kinase abl1 (ec 2.7.1.112) (p150) (c-abl). [swissprot;acc:p00519]	Low confidence	199.275	194.918	1.02235
	serine/threonine protein phosphatase 2b catalytic subunit, gamma isoform (ec 3.1.3.16) (calmodulin-dependent calcineurin a subunit, gamma isoform) (calcineurin, testis-specific catalytic subunit) (cam-prp catalytic subunit). [swissprot;acc:p48454]	High confidence	218.441	213.441	1.02343
1307	myotubularin-related protein 1 (ec 3.1.3.-). [swissprot;acc:q13613]	Low confidence	204.064	199.602	1.02235
	serine/threonine protein phosphatase 2b catalytic subunit, beta isoform (ec 3.1.3.16) (calmodulin-dependent calcineurin a subunit, beta isoform) (cam-prp catalytic subunit). [swissprot;acc:p16299]	High confidence	218.44	213.44	1.02343
1308	grb2-related adaptor protein 2 (gads protein) (growth factor receptor binding protein) (grblg) (grf40 adaptor protein) (grf-40) (grb-2-like protein) (grb2l) (grbx) (p38) (hematopoietic cell-associated adaptor protein grpl) (adapter protein grid) (sh3-sh2-sh3 adaptor mona). [swissprot;acc:o75791]	Low confidence	199.268	194.914	1.02234
	p protein (melanocyte-specific transporter protein). [swissprot;acc:q04671]	High confidence	218.44	213.439	1.02343
1309	prefoldin subunit 3 (von hippel-lindau binding protein 1) (vhl binding protein-1) (vbp-1) (hibbj46). [swissprot;acc:q15765]		226.439	221.26	1.02341
	splicing factor, proline-and glutamine-rich (polypyrimidine tract- binding protein-associated splicing factor) (ptb-associated splicing factor) (psf) (dna-binding p52/p100 complex, 100 kda subunit). [swissprot;acc:p23246]	Low confidence	200.536	196.157	1.02232
1310	p66 alpha. [refseq;acc:nm_017660]		229.478	224.473	1.0223
	prefoldin subunit 2 (hspc231). [swissprot;acc:q9uhv9]	High confidence	226.439	221.26	1.02341
1311	transcription repressor p66 beta component of the mecp1 complex. [refseq;acc:nm_020699]	Low confidence	229.478	224.473	1.0223
	uxt protein (ubiquitously expressed transcript protein) (hspc024). [swissprot;acc:q9ubk9]	High confidence	226.439	221.26	1.02341
1312	rad50 homolog isoform 1. [refseq;acc:nm_005732]		199.739	204.407	1.02337
	tyrosine aminotransferase (ec 2.6.1.5) (l-tyrosine:2-oxoglutarate aminotransferase) (tat). [swissprot;acc:p17735]	Low confidence	229.478	224.473	1.0223
1313	serologically defined colon cancer antigen 1. [refseq;acc:nm_004713]		202.396	197.985	1.02228
	signal transducer and activator of transcription 3 (acute-phase response factor). [swissprot;acc:p40763]	High confidence	222.573	227.75	1.02326
1314	dnaj homolog subfamily b member 1 (heat shock 40 kda protein 1) (heat shock protein 40) (hsp40) (dnaj protein homolog 1) (hdj-1). [swissprot;acc:p25685]	Low confidence	201.948	197.549	1.02227
	signal transducer and activator of transcription 4. [swissprot;acc:q14765]	High confidence	222.573	227.751	1.02326
1315	ataxin-1 ubiquitin-like interacting protein. [refseq;acc:nm_020131]	Low confidence	206.697	202.196	1.02226
	signal transducer and activator of transcription 1-alpha/beta (transcription factor isgf-3 components p91/p84). [swissprot;acc:p42224]	High confidence	222.574	227.752	1.02326
1316	schwannomin interacting protein 1. [refseq;acc:nm_014575]	Low confidence	201.232	196.85	1.02226
	signal transducer and activator of transcription 6 (il-4 stat). [swissprot;acc:p42226]	High confidence	222.569	227.739	1.02323
1317	cbf1 interacting corepressor. [refseq;acc:nm_004882]	Low confidence	203.649	199.217	1.02225
	centromere protein j; centrosomal p4.1-associated protein; lyst-interacting protein lip1; lag-3-associated protein. [refseq;acc:nm_018451]	High confidence	206.773	202.105	1.0231
1318	evolutionarily conserved g-patch domain containing. [refseq;acc:nm_018025]	Low confidence	203.649	199.217	1.02225
	signal transducer and activator of transcription 5a. [swissprot;acc:p42229]	High confidence	222.546	227.673	1.02304
1319	fatty aldehyde dehydrogenase (ec 1.2.1.3) (aldehyde dehydrogenase, microsomal) (aldh class 3). [swissprot;acc:p51648]	Low confidence	208.606	213.247	1.02225
	glycogen [starch] synthase, muscle (ec 2.4.1.11). [swissprot;acc:p13807]	High confidence	159.75	156.153	1.02304
1320	mitogen-activated protein kinase 14 (ec 2.7.1.37) (mitogen-activated protein kinase p38alpha) (map kinase p38alpha) (cytokine suppressive anti-inflammatory drug binding protein) (csaid binding protein) (csbp) (max-interacting protein 2) (map kinase mxi2) (sapk2a). [swissprot;acc:q16539]	Low confidence	200.171	195.819	1.02222
	signal transducer and activator of transcription 5b. [swissprot;acc:p51692]	High confidence	222.544	227.667	1.02302
1321	c316g12.2 (novel protein similar to predicted yeast, worm and archae- bacterial proteins) (similar to und313) (s. cervisiae) (hypothetical protein). [sptrembl;acc:q9ujk0]	Low confidence	199.938	195.591	1.02222
	probable dimethyladenosine transferase (ec 2.1.1.-) (s- adenosylmethionine-6-n',n'-adenosyl(rrna) dimethyltransferase) (18s rrna dimethylase). [swissprot;acc:q9unq2]	High confidence	226.347	221.259	1.023
1322	1-acyl-sn-glycerol-3-phosphate acyltransferase beta (ec 2.3.1.51) (1- agp acyltransferase 2) (1-agpat 2) (lysophosphatidic acid acyltransferase-beta) (lpaat-beta) (1-acylglycerol-3-phosphate o- acyltransferase 2). [swissprot;acc:o15120]	Low confidence	198.322	194.014	1.0222
	endo-beta-n-acetylglucosaminidase. [refseq;acc:nm_022759]	High confidence	159.86	156.275	1.02294
1323	cytoplasmic protein nck2 (nck adaptor protein 2) (sh2/sh3 adaptor protein nck-beta) (nck-2). [swissprot;acc:o43639]		205.225	200.625	1.02293
	neuronal guanine nucleotide exchange factor. [refseq;acc:nm_019850]	Low confidence	203.926	199.498	1.0222
1324	beta-galactosidase precursor (ec 3.2.1.23) (lactase) (acid beta- galactosidase). [swissprot;acc:p16278]		203.758	199.335	1.02219
	glycogen [starch] synthase, liver (ec 2.4.1.11). [swissprot;acc:p54840]	High confidence	159.993	156.421	1.02284
1325	dnaj homolog subfamily b member 4 (heat shock 40 kda protein 1 homolog) (heat shock protein 40 homolog) (hsp40 homolog). [swissprot;acc:q9udy4]	Low confidence	201.909	197.526	1.02219
	werner helicase interacting protein isoform 1; putative helicase ruvbl; werner helicase interacting protein. [refseq;acc:nm_020135]	High confidence	217.133	212.289	1.02282

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.