MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 51 to 100 of 9634 in total

Value Type  : Ranked
Network Comparison Type  : Divided

Rank	Hugo	description	Interaction Map	Filtered	red	green	network_comparison
13	SORD	sorbitol dehydrogenase (ec 1.1.1.14) (l-iditol 2-dehydrogenase). [swissprot;acc:q00796]	Low confidence	0	7435.56	12191.6	1.63963
	UFC1	protein cgi-126 (protein hspc155). [swissprot;acc:q9y3c8]	High confidence	1	288.754	212.554	1.3585
14	no value	dystrophin. [swissprot;acc:p11532]		0	10232.5	18054.8	1.76446
		ptd016 protein. [refseq;acc:nm_016125]	Low confidence		18050	11234	1.60673
	ATG4A	cysteine endopeptidase aut-like 2 isoform a; autophagy-related cysteine endopeptidase 2; autophagin 2. [refseq;acc:nm_052936]	High confidence	1	56.6768	75.3531	1.32952
	BEST2	vitelliform macular dystrophy 2-like protein 1. [refseq;acc:nm_017682]	Low confidence		37.9984	29.1831	1.30207
15	no value	succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial precursor (cybs) (succinate-ubiquinone reductase membrane anchor subunit) (qps2) (cii-4) (succinate dehydrogenase complex subunit d) (succinate-ubiquinone oxidoreductase cytochrome b small subunit). [swissprot;acc:o14521]	High confidence	0	19403	11267	1.72211
	APC2	adenomatous polyposis coli like. [refseq;acc:nm_005883]	Low confidence		12074.1	7597.61	1.5892
	MAP1LC3B	microtubule-associated proteins 1a/1b light chain 3b (map1a/map1b lc3 b) (map1a/1b light chain 3 b). [swissprot;acc:q9gzq8]	High confidence	1	56.7244	75.3948	1.32914
	UFC1	protein cgi-126 (protein hspc155). [swissprot;acc:q9y3c8]	Low confidence		255.046	202.362	1.26035
16	no value	beta-carotene dioxygenase 2; putative b,b-carotene-9',10'-dioxygenase. [refseq;acc:nm_031938]		0	7395	11625	1.57201
	CCNH	cyclin h (mo15-associated protein) (p37) (p34). [swissprot;acc:p51946]	High confidence		12170.7	20670.6	1.69839
	JMJD1C	thyroid receptor interacting protein 8 (trip-8) (fragment). [swissprot;acc:q15652]	Low confidence	1	305.472	247.246	1.2355
	MAP1LC3A	microtubule-associated proteins 1a/1b light chain 3a (map1a/map1b lc3 a) (map1a/1b light chain 3 a). [swissprot;acc:q9h492]	High confidence		56.7252	75.3954	1.32913
17	no value	fatty acid desaturase 1; linoleoyl-coa desaturase (delta-6-desaturase)-like 1; delta-5 desaturase; delta-5 fatty acid desaturase. [refseq;acc:nm_013402]		0	11543	6812	1.69451
	ATG4B	cysteine endopeptidase aut-like isoform b. [refseq;acc:nm_178326]		1	56.7841	75.447	1.32866
	LRRFIP1	leucine rich repeat (in flii) interacting protein 1. [refseq;acc:nm_004735]	Low confidence	0	8082.33	5266.67	1.53462
	TMEM132A	gbp protein isoform a. [refseq;acc:nm_017870]		1	305.399	247.213	1.23537
18	no value	early hematopoietic zinc finger. [refseq;acc:nm_015461]		0	5850.23	8903.28	1.52187
		homeobox protein hox-c4 (hox-3e) (cp19). [swissprot;acc:p09017]	High confidence		22286	13216	1.68629
	GBE1	1,4-alpha-glucan branching enzyme (ec 2.4.1.18) (glycogen branching enzyme) (brancher enzyme). [swissprot;acc:q04446]		1	185.678	245.247	1.32082
	JMJD1A	jumonji domain containing 1; zinc finger protein; testis-specific protein a. [refseq;acc:nm_018433]	Low confidence		305.303	247.169	1.2352
19	no value	homeobox protein hox-c6 (hox-3c) (hho.c8) (cp25). [swissprot;acc:p09630]	High confidence	0	22286	13216	1.68629
		nuclear dna-binding protein; small unique nuclear receptor corepressor; c1d dna-binding protein. [refseq;acc:nm_006333]	Low confidence		3208.8	4871.6	1.5182
	PRSS3	trypsin iii precursor (ec 3.4.21.4) (brain trypsinogen) (mesotrypsinogen) (trypsin iv). [swissprot;acc:p35030]		1	304.548	246.824	1.23387
	PYGB	glycogen phosphorylase, brain form (ec 2.4.1.1). [swissprot;acc:p11216]	High confidence		185.678	245.247	1.32082
20	no value	homeobox protein hox-a4 (hox-1d) (hox-1.4). [swissprot;acc:q00056]		0	22286	13216	1.68629
	GNB1L	guanine nucleotide-binding protein beta subunit-like protein 1 (g protein beta-subunit like protein 1) (wd40 repeat containing protein deleted in vcfs) (wdvcf protein) (fksg1 protein) (dgcrk3). [swissprot;acc:q9byb4]	Low confidence		22422	14964	1.4984
	PRSS1	trypsin i precursor (ec 3.4.21.4) (cationic trypsinogen). [swissprot;acc:p07477]		1	304.359	246.737	1.23354
	PYGL	glycogen phosphorylase, liver form (ec 2.4.1.1). [swissprot;acc:p06737]	High confidence		185.678	245.247	1.32082
21	no value	dj570f3.6 (novel protein similar to lysophospholipase ii (lypla2)). [sptrembl;acc:q9uge0]	Low confidence	0	3859	2582	1.49458
	ACRC	acrc protein; putative nuclear protein. [refseq;acc:nm_052957]	High confidence		6313.38	10621.4	1.68236
	MYO15A	myosin xv (unconventional myosin-15). [swissprot;acc:q9ukn7]		1	185.678	245.247	1.32082
	PIGF	phosphatidylinositol-glycan biosynthesis, class f protein (pig-f). [swissprot;acc:q07326]	Low confidence		198	163	1.21472
22	CTSZ	cathepsin z precursor (ec 3.4.22.-) (cathepsin x) (cathepsin p). [swissprot;acc:q9ubr2]		0	11515	7867	1.46371
	PNPO	pyridoxine 5'-phosphate oxidase. [refseq;acc:nm_018129]	High confidence		20989	12479	1.68195
	PYGM	glycogen phosphorylase, muscle form (ec 2.4.1.1) (myophosphorylase). [swissprot;acc:p11217]		1	185.678	245.247	1.32082
	TUSC3	n33 protein. [swissprot;acc:q13454]	Low confidence		198	163	1.21472
23	no value	implantation-associated protein. [refseq;acc:nm_032121]
	HGS	hepatocyte growth factor-regulated tyrosine kinase substrate; human growth factor-regulated tyrosine kinase substrate. [refseq;acc:nm_004712]	High confidence	0	15520.4	9285.44	1.67148
	MRPS17	28s ribosomal protein s17, mitochondrial precursor (mrp-s17) (hspc011). [swissprot;acc:q9y2r5]		1	58	44	1.31818
	SERPINB12	serpin b12. [swissprot;acc:q96p63]	Low confidence	0	14604.2	21138.6	1.44743
24	no value	ba508n22.1 (hspc025) (fragment). [sptrembl;acc:q9hcw5]	High confidence		13730.5	8257	1.66289
		hurpin (hacat uv-repressible serpin) (protease inhibitor 13) (headpin) (serpin b13). [swissprot;acc:q9uiv8]	Low confidence		14592	21113.7	1.44694
	HINT1	histidine triad nucleotide-binding protein 1 (adenosine 5'- monophosphoramidase) (protein kinase c inhibitor 1) (protein kinase c- interacting protein 1) (pkci-1). [swissprot;acc:p49773]		1	188.298	228.509	1.21355
	PANK1	pantothenate kinase 1 (ec 2.7.1.33) (pantothenic acid kinase 1) (hpank1) (hpank). [swissprot;acc:q8te04]	High confidence		58	44	1.31818
25	no value	lipopolysaccharide-responsive and beige-like anchor protein (cdc4-like protein) (beige-like protein). [swissprot;acc:p50851]		0	13730.5	8257	1.66289
	CYP27B1	25-hydroxyvitamin d-1 alpha hydroxylase, mitochondrial precursor (ec 1.14.-.-) (25-ohd-1 alpha-hydroxylase) (25-hydroxyvitamin d3 1- alpha-hydroxylase) (vd3 1a hydroxylase) (p450c1 alpha) (p450vd1- alpha). [swissprot;acc:o15528]	Low confidence	1	286.396	238.476	1.20094
	NDUFA5	nadh-ubiquinone oxidoreductase 13 kda-b subunit (ec 1.6.5.3) (ec 1.6.99.3) (complex i-13kd-b) (ci-13kd-b) (complex i subunit b13). [swissprot;acc:q16718]		0	9830	6909	1.42278
	PANK2	pantothenate kinase 2, mitochondrial precursor (ec 2.7.1.33) (pantothenic acid kinase 2) (hpank2). [swissprot;acc:q9bz23]	High confidence	1	58	44	1.31818

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.