MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 51 to 100 of 247 in total

Hugo  : no value
Value Type  : Ranked
Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 0

Rank	description	red	green	network_comparison
120	presenilin-like protein 1 (ec 3.4.99.-) (sppl2b protein). [swissprot;acc:q8tct7]	5797	4873	1.18962
124	zinc finger imprinted 2. [swissprot;acc:q9nzv7]	11520.7	13680.4	1.18746
126	ret finger protein 2 (leukemia associated protein 5) (b-cell chronic lymphocytic leukemia tumor suppressor leu5) (putative tumor suppressor rfp2) (tripartite motif protein 13). [swissprot;acc:o60858]	9722.71	11493.8	1.18216
128	60s ribosomal protein l39. [swissprot;acc:p02404]	11564.4	9794.29	1.18073
129	isoleucyl-trna synthetase, cytoplasmic (ec 6.1.1.5) (isoleucine--trna ligase) (ilers) (irs). [swissprot;acc:p41252]	14222.5	12058.6	1.17945
130	enigma protein; lim domain protein. [refseq;acc:nm_005451]	14476.2	17069.5	1.17914
132	rna helicase-related protein; rna helicase-like protein; sf3b125 dead-box protein. [refseq;acc:nm_007372]	19048	22389	1.1754
133	alpha-parvin (calponin-like integrin-linked kinase binding protein) (ch-ilkbp). [swissprot;acc:q9nvd7]	6814	8009	1.17537
140	mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476]	16411.9	14027.1	1.17001
143	dna directed rna polymerase ii polypeptide j-related gene isoform 3; rpb11b1alpha protein; rpb11b1beta; dna-directed rna polymerase ii subunit 11. [refseq;acc:nm_032959]	11124.8	13005.3	1.16904
144	dna directed rna polymerase ii polypeptide j-related gene isoform 1; rpb11b1alpha protein; rpb11b1beta; dna-directed rna polymerase ii subunit 11. [refseq;acc:nm_145325]	11123.4	13000.1	1.16872
147	60s ribosomal protein l7. [swissprot;acc:p18124]	11080.3	9505.89	1.16562
149	block 23. [sptrembl;acc:q8nhw5]	11469.3	13334.8	1.16265
151	u2 small nuclear ribonucleoprotein auxiliary factor 35 kda subunit related-protein 1. [swissprot;acc:q15695]	7502.08	6461.83	1.16098
152	similar to ribosomal protein, large, p0. [sptrembl;acc:q96fq9]	11438	13277.1	1.16079
154	myosin va (myosin 5a) (dilute myosin heavy chain, non-muscle) (myosin heavy chain 12) (myoxin). [swissprot;acc:q9y4i1]	10883	12622.8	1.15986
157	transcription initiation factor iie, beta subunit (tfiie-beta). [swissprot;acc:p29084]	18079	15652	1.15506
160	ccr4-not transcription complex, subunit 7 (ccr4-associated factor 1) (caf1) (btg1 binding factor 1). [swissprot;acc:q9uiv1]	11732	13530.6	1.15331
162	putative eukaryotic translation initiation factor 1a (eif-1a) (eif- 4c). [swissprot;acc:o75642]	12301.4	10680.5	1.15176
164	dihydrofolate reductase (ec 1.5.1.3). [swissprot;acc:p00374]	11971.7	10412.4	1.14975
165	ribose-phosphate pyrophosphokinase iii (ec 2.7.6.1) (phosphoribosyl pyrophosphate synthetase iii) (prs-iii). [swissprot;acc:p21108]	13255.4	15183.2	1.14544
171	lamin b2. [swissprot;acc:q03252]	12135.4	13802	1.13733
173	suppressor of actin 1. [refseq;acc:nm_014016]	19088.1	16804.6	1.13589
174	ribulose-5-phosphate-3-epimerase; ribulose 5-phosphate 3-epimerase. [refseq;acc:nm_006916]	13248.5	11666.4	1.13561
175	thiamin pyrophosphokinase 1; mouse thiamin pyrophosphokinase homolog; thiamine pyrophosphokinase. [refseq;acc:nm_022445]
176	dead-box protein abstrakt homolog. [swissprot;acc:q9ujv9]	13068	11528	1.13359
178	integral membrane protein cii-3b. [sptrembl;acc:o75609]	14951.6	13204.2	1.13234
181	importin 7; ran-binding protein 7. [refseq;acc:nm_006391]	14864.7	16820.7	1.13159
183	ubiquitin activating enzyme e1-like protein. [refseq;acc:nm_006395]	11613	13133.5	1.13093
184	similar to zinc finger protein 277. [sptrembl;acc:q8wwa6]	6279.56	5569.42	1.12751
185	zinc finger protein 277. [swissprot;acc:q9nrm2]
186	40s ribosomal protein s2 (s4) (llrep3 protein). [swissprot;acc:p15880]	11935.1	10592.8	1.12672
190	high-glucose-regulated protein 8 (ny-ren-2 antigen). [swissprot;acc:q9y5a9]	18809.5	16764.2	1.122
191	sh3 adapter protein spin90 (sh3 protein interacting with nck, 90 kda) (vaca-interacting protein, 54 kda) (vip54) (af3p21) (diaphanous protein interacting protein) (dia interacting protein-1) (dip-1). [swissprot;acc:q9nzq3]
194	kappa b-ras 1. [refseq;acc:nm_020345]	12657.7	11299.1	1.12024
196	suppressor of ty 5 homolog; suppressor of ty (s.cerevisiae) 5 homolog. [refseq;acc:nm_003169]	11064.2	9897.84	1.11784
197	importin 4. [refseq;acc:nm_024658]	12337.6	13788.9	1.11763
199	60s ribosomal protein l10 (qm protein) (tumor suppressor qm) (laminin receptor homolog). [swissprot;acc:p27635]	11781.8	10545.7	1.11721
201	maspin precursor (protease inhibitor 5). [swissprot;acc:p36952]	16853	15123	1.1144
202	serpin b11. [swissprot;acc:q96p15]
203	cytoplasmic antiproteinase 2 (cap2) (cap-2) (protease inhibitor 8) (serpin b8). [swissprot;acc:p50452]
205	60s ribosomal protein l23a. [swissprot;acc:p29316]	11844.9	10636.3	1.11363
206	hepatitis c virus core-binding protein 6; cervical cancer oncogene 3. [refseq;acc:nm_023934]	7479	6716	1.11361
207	dc11 protein. [refseq;acc:nm_020186]
208	c367g8.3 (novel protein similar to rpl23a (60s ribosomal protein l23a)) (60s ribosomal protein l23a like). [sptrembl;acc:q9br02]	11846.3	10638.4	1.11354
209	small nuclear ribonucleoprotein e (snrnp-e) (sm protein e) (sm-e) (sme). [swissprot;acc:p08578]	775	696	1.11351
211	ribosomal protein s6 kinase-like 1. [refseq;acc:nm_031464]	10367	9320.25	1.11231
212	metabotropic glutamate receptor 3 precursor (mglur3). [swissprot;acc:q14832]	18241.7	16405	1.11196
215	myosin vi. [swissprot;acc:q9um54]	10121.5	11250.5	1.11154
218	lim domain binding 1; carboxy terminal lim domain protein 2; lim domain-binding factor-1. [refseq;acc:nm_003893]	19355	17469.2	1.10795

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.