MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 451 to 500 of 9634 in total

Value Type  : Ranked
Network Comparison Type  : Divided

Rank	Hugo	description	Interaction Map	Filtered	red	green	network_comparison
113	DVL1	segment polarity protein dishevelled homolog dvl-1 (dishevelled-1) (dsh homolog 1). [swissprot;acc:o14640]	High confidence	0	5673.33	6797.56	1.19816
	KHDRBS3	kh domain containing, rna binding, signal transduction associated 3; sam68-like phosphotyrosine protein, t-star. [refseq;acc:nm_006558]		1	332.874	267.246	1.24557
114	no value	bloom's syndrome protein (ec 3.6.1.-) (recq protein-like 3) (dna helicase, recq-like, type 2). [swissprot;acc:p54132]		0	8871.11	10603.2	1.19525
	DLGAP1	disks large-associated protein 1 (dap-1) (guanylate kinase-associated protein) (hgkap) (sap90/psd-95-associated protein 1) (sapap1) (psd- 95/sap90 binding protein 1). [swissprot;acc:o14490]	Low confidence	1	197.779	211.983	1.07182
	ETV7	transcription factor tel-2 (ets-related protein tel2) (tel related ets factor). [swissprot;acc:q9y603]		0	7730.67	9278.67	1.20024
	KHDRBS1	kh domain containing, rna binding, signal transduction associated 1; gap-associated tyrosine phosphoprotein p62 (sam68). [refseq;acc:nm_006559]	High confidence	1	332.874	267.246	1.24557
115	no value	small nuclear ribonucleoprotein e (snrnp-e) (sm protein e) (sm-e) (sme). [swissprot;acc:p08578]	Low confidence	0	10216.9	12255.4	1.19952
		spir-2 protein (fragment). [sptrembl;acc:q8wwl2]	High confidence		18662.8	15627	1.19427
	DLGAP4	disks large-associated protein 4 (dap-4) (sap90/psd-95-associated protein 4) (sapap4) (psd-95/sap90 binding protein 4). [swissprot;acc:q9y2h0]	Low confidence	1	197.779	211.983	1.07182
	KHDRBS2	kh domain-containing, rna-binding, signal transduction-associated protein 2; sam68-like mammalian protein 1. [refseq;acc:nm_152688]	High confidence		332.874	267.246	1.24557
116	DVL1	segment polarity protein dishevelled homolog dvl-1 (dishevelled-1) (dsh homolog 1). [swissprot;acc:o14640]	Low confidence	0	5673.33	6797.56	1.19816
	GNB3	guanine nucleotide-binding protein g(i)/g(s)/g(t) beta subunit 3 (transducin beta chain 3). [swissprot;acc:p16520]	High confidence	1	268.565	334.483	1.24545
	MTX1	metaxin 1. [swissprot;acc:q13505]		0	13761.3	16422.1	1.19335
	VPS18	vacuolar protein sorting 18 (hvps18). [swissprot;acc:q9p253]	Low confidence	1	204.161	190.791	1.07008
117	no value	basic proline-rich peptide p-e (ib-9). [swissprot;acc:p02811]	High confidence	0	11545	13771.5	1.19285
	CHMP4A	protein hspc134 (protein cda04). [swissprot;acc:q9by43]	Low confidence		11114.8	13288.7	1.19559
	F13A1	coagulation factor xiii a chain precursor (ec 2.3.2.13) (protein- glutamine gamma-glutamyltransferase a chain) (transglutaminase a chain). [swissprot;acc:p00488]		1	226.395	211.713	1.06935
	NEURL	neuralized-like. [refseq;acc:nm_004210]	High confidence		332.326	266.948	1.24491
118	no value	lipopolysaccharide-responsive and beige-like anchor protein (cdc4-like protein) (beige-like protein). [swissprot;acc:p50851]	Low confidence	0	11535.2	9652.56	1.19504
	AQP2	aquaporin-cd (aqp-cd) (water channel protein for renal collecting duct) (adh water channel) (aquaporin 2) (collecting duct water channel protein) (wch-cd). [swissprot;acc:p41181]	High confidence		12049	14370.7	1.19269
	NDUFA12	nadh-ubiquinone oxidoreductase subunit b17.2 (ec 1.6.5.3) (ec 1.6.99.3) (complex i-b17.2) (ci-b17.2) (cib17.2) (13 kda differentiation-associated protein). [swissprot;acc:q9ui09]		1	284.753	228.934	1.24382
	TGM1	protein-glutamine gamma-glutamyltransferase k (ec 2.3.2.13) (transglutaminase k) (tgase k) (tgk) (tg(k)) (transglutaminase 1) (epidermal tgase). [swissprot;acc:p22735]	Low confidence		226.395	211.713	1.06935
119	no value	cdc42-binding protein kinase beta; cdc42-binding protein kinase beta (dmpk-like); mrck beta; dmpk-like. [refseq;acc:nm_006035]		0	5797	4873	1.18962
		mesoderm induction early response 1. [refseq;acc:nm_020948]	High confidence		3609	4302.5	1.19216
	NDUFS4	nadh-ubiquinone oxidoreductase 18 kda subunit, mitochondrial precursor (ec 1.6.5.3) (ec 1.6.99.3) (complex i-18 kda) (ci-18 kda) (complex i- aqdq) (ci-aqdq). [swissprot;acc:o43181]		1	318.982	259.004	1.23157
	SLC11A1	natural resistance-associated macrophage protein 1 (nramp 1). [swissprot;acc:p49279]	Low confidence		225.666	211.107	1.06897
120	no value	presenilin-like protein 1 (ec 3.4.99.-) (sppl2b protein). [swissprot;acc:q8tct7]	High confidence	0	5797	4873	1.18962
			Low confidence
	DVL1	segment polarity protein dishevelled homolog dvl-1 (dishevelled-1) (dsh homolog 1). [swissprot;acc:o14640]		1	203.016	189.965	1.0687
	KCND2	potassium voltage-gated channel, shal-related subfamily, member 2; voltage-sensitive potassium channel; voltage-gated potassium channel kv4.2. [refseq;acc:nm_012281]	High confidence		269.278	327.709	1.21699
121	ARFGAP3	adp-ribosylation factor gtpase-activating protein 3 (arf gap 3). [swissprot;acc:q9np61]	Low confidence	0	10652.4	12636.7	1.18628
	CTH	cystathionine gamma-lyase (ec 4.4.1.1) (gamma-cystathionase). [swissprot;acc:p32929]	High confidence	1	269.254	327.655	1.2169
	DVL2	segment polarity protein dishevelled homolog dvl-2 (dishevelled-2) (dsh homolog 2). [swissprot;acc:o14641]	Low confidence		203.007	189.985	1.06854
	ZNF232	zinc finger protein 232. [swissprot;acc:q9uny5]	High confidence	0	11523.7	13686.9	1.18772
122	no value	nanos (fragment). [sptrembl;acc:q8wy41]	Low confidence	1	203.66	217.479	1.06785
	HGS	hepatocyte growth factor-regulated tyrosine kinase substrate; human growth factor-regulated tyrosine kinase substrate. [refseq;acc:nm_004712]		0	12458.3	10506.7	1.18575
	KCND3	potassium voltage-gated channel, shal-related subfamily, member 3 isoform 1; sha1-related potassium channel kv4.3; voltage-gated k+ channel; potassium ionic channel kv4.3; voltage-gated potassium channel kv4.3. [refseq;acc:nm_004980]	High confidence	1	269.248	327.642	1.21688
	ZNF24	zinc finger protein 24 (zinc finger protein 191) (zinc finger protein kox17) (retinoic acid suppression protein a) (rsg-a). [swissprot;acc:p17028]		0	11523	13685.4	1.18766
123	DVL3	segment polarity protein dishevelled homolog dvl-3 (dishevelled-3) (dsh homolog 3). [swissprot;acc:q92997]	Low confidence	1	202.96	190.094	1.06768
	KCND1	potassium voltage-gated channel, shal-related subfamily, member 1; shal-type potassium channel; voltage-gated potassium channel kv4.1. [refseq;acc:nm_004979]	High confidence		269.23	327.601	1.21681
	RBM15	putative rna-binding protein 15 (rna binding motif protein 15) (one-twenty two protein). [swissprot;acc:q96t37]	Low confidence	0	11725.7	13865.5	1.18249
	ZNF215	zinc finger protein 215 (bwscr2 associated zinc-finger protein 2) (baz 2). [swissprot;acc:q9ul58]	High confidence		11522.8	13684.9	1.18764
124	no value	zinc finger imprinted 2. [swissprot;acc:q9nzv7]			11520.7	13680.4	1.18746
	HMG20B	high-mobility group 20b; sox-like transcriptional factor; swi/snf-related matrix-associated actin-dependent regulator of chromatin subfamily e, member 1-related. [refseq;acc:nm_006339]		1	208.52	171.595	1.21519
	PDSS1	trans-prenyltransferase; polyprenyl pyrophosphate synthetase. [refseq;acc:nm_014317]	Low confidence	0	9351.39	11039.5	1.18052
	SLC11A2	natural resistance-associated macrophage protein 2 (nramp 2) (divalent metal transporter 1) (dmt1). [swissprot;acc:p49281]		1	224.763	210.566	1.06742
125	no value	small edrk-rich factor 1a. [swissprot;acc:o75920]		0	4824.5	5690.5	1.1795
	B9D1	b9 protein; likely ortholog of mouse endothelial precursor protein b9. [refseq;acc:nm_015681]		1	213.243	227.616	1.0674
	HMG20A	high-mobility group 20a. [refseq;acc:nm_018200]	High confidence		208.588	171.778	1.21429
	PIK3C2B	phosphatidylinositol-4-phosphate 3-kinase c2 domain-containing beta polypeptide (ec 2.7.1.154) (phosphoinositide 3-kinase-c2-beta) (ptdins-3-kinase c2 beta) (pi3k-c2beta) (c2-pi3k). [swissprot;acc:o00750]		0	22038	18578	1.18624

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.