MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 223 to 247 of 247 in total

Hugo  : no value
Value Type  : Ranked
Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 0

Rank	description	red	green	network_comparison
460	mitochondrial 28s ribosomal protein s6 (mrp-s6). [swissprot;acc:p82932]	20914	20558	1.01732
461	scratch; scratch 1. [refseq;acc:nm_031309]	12164.9	12358.1	1.01588
462	dj850e9.1 (novel c2h2 type zinc finger protein similar to drosophila scratch (scrt), slug and xenopus snail) (fragment). [sptrembl;acc:q9nq03]	12189.6	12378.3	1.01548
463	dj153g14.2 (possible ca binding protein similar to nefa) (fragment). [sptrembl;acc:q9ujn8]	5558.06	5473.99	1.01536
464	ba395l14.12 (novel protein similar to small nuclear ribonucleoprotein polypeptide a' (snrpa1)). [sptrembl;acc:q9nu36]	10076.4	9928.08	1.01494
465	transducin-like enhancer protein 1 (esg1). [swissprot;acc:q04724]	9482.68	9620.66	1.01455
466	aspartate beta-hydroxylase isoform b; junctin isoform 1; junctate; aspartyl/asparaginyl-beta-hydroxylase; peptide-aspartate beta-dioxygenase; humbug. [refseq;acc:nm_032468]	1543	1521	1.01446
467	histone h2a.c/d/i/n/p (h2a.1) (h2a/c) (h2a/d) (h2a/i) (h2a/n) (h2a/p) (h2a.1b). [swissprot;acc:p02261]	21205	20914	1.01391
475	adp-ribosylation factor-like protein 7 (adp-ribosylation factor-like protein lak). [swissprot;acc:p56559]	18667	18500	1.00903
476	atlastin; guanylate-binding protein 3. [refseq;acc:nm_015915]	8403	8329	1.00888
477	ubiquitin-conjugating enzyme e2-17 kda 3 (ec 6.3.2.19) (ubiquitin- protein ligase) (ubiquitin carrier protein) (e2(17)kb 3). [swissprot;acc:p47986]	15920	15780.2	1.00886
481	uridine kinase-like 1. [swissprot;acc:q9nwz5]	11554.3	11462.4	1.00802
482	kinesin-like protein kif13b (kinesin-like protein gakin). [swissprot;acc:q9nqt8]	6156.33	6205.67	1.00801
483	tyrosine aminotransferase (ec 2.6.1.5) (l-tyrosine:2-oxoglutarate aminotransferase) (tat). [swissprot;acc:p17735]	12223.8	12127.5	1.00794
485	pepsin a precursor (ec 3.4.23.1). [swissprot;acc:p00790]	12461.5	12542.3	1.00648
487	survival motor neuron protein (component of gems 1) (gemin1). [swissprot;acc:q16637]	13236.8	13159.3	1.00589
488	heat shock factor binding protein 1. [swissprot;acc:o75506]	15204.2	15127.8	1.00505
490	dna-directed rna polymerase i 16 kda polypeptide (ec 2.7.7.6) (rpa16). [swissprot;acc:q9y2s0]	10388.7	10338.7	1.00484
493	dj470l14.3 (novel protein similar to the arp2/3 protein complex subunit p21-arc (arc21)). [sptrembl;acc:q9h5b6]	11999.1	12041.7	1.00355
494	signal recognition particle receptor alpha subunit (sr-alpha) (docking protein alpha) (dp-alpha). [swissprot;acc:p08240]	11985.5	11959.4	1.00218
495	26s proteasome non-atpase regulatory subunit 12 (26s proteasome regulatory subunit p55). [swissprot;acc:o00232]	11725.2	11748.1	1.00195
496	vacuolar atp synthase subunit g 2 (ec 3.6.3.14) (v-atpase g subunit 2) (vacuolar proton pump g subunit 2) (v-atpase 13 kda subunit 2). [swissprot;acc:o95670]	9394	9411.49	1.00186
497	sh2 domain binding protein 1; tpr-containing, sh2-binding phosphoprotein. [refseq;acc:nm_014633]	13692.7	13718.2
498	adenylate kinase isoenzyme 4, mitochondrial (ec 2.7.4.3) (atp-amp transphosphorylase). [swissprot;acc:p27144]	10231.8	10248.3	1.00161
500	huntingtin interacting protein e; huntingtin interactor protein e. [refseq;acc:nm_007076]	394	394	1

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.