MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 101 to 150 of 247 in total

Hugo  : no value
Value Type  : Ranked
Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 0

Rank	description	red	green	network_comparison
221	estrogen-related receptor gamma (estrogen receptor related protein 3) (err gamma-2). [swissprot;acc:o75454]	12190.3	13497.2	1.10721
222	40s ribosomal protein s15 (rig protein). [swissprot;acc:p11174]	12183	11013.2	1.10622
223	pnas-18. [sptrembl;acc:q9bzu3]	12602.7	13939.6	1.10608
225	40s ribosomal protein s29. [swissprot;acc:p30054]	11035.3	9997.71	1.10378
226	rab gdp dissociation inhibitor alpha (rab gdi alpha) (gdi-1) (xap-4) (oligophrenin 2). [swissprot;acc:p31150]	15395.7	16992.9	1.10374
229	poly (adp-ribose) glycohydrolase. [refseq;acc:nm_003631]	10899.4	9878.1	1.10339
233	60s acidic ribosomal protein p1. [swissprot;acc:p05386]	9586.97	10560	1.1015
234	transcription factor 4 (immunoglobulin transcription factor 2) (itf-2) (sl3-3 enhancer factor 2) (sef-2). [swissprot;acc:p15884]	16614	18296	1.10124
237	bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthethase 2 (paps synthethase 2) (papss 2) (sulfurylase kinase 2) (sk2) (sk 2) [includes: sulfate adenylyltransferase (ec 2.7.7.4) (sulfate adenylate transferase) (sat) (atp-sulfurylase); adenylylsulfate kinase (ec 2.7.1.25) (adenylylsulfate 3'-phosphotransferase) (aps kinase) (adenosine-5'-phosphosulfate 3'-phosphotransferase) (3'- phosphoadenosine-5'-phosphosulfate synthetase)]. [swissprot;acc:o95340]	9984	9067	1.10114
238	cyclin-dependent kinases regulatory subunit 1 (cks-1) (sid1334) (pnas-16 / pnas-143). [swissprot;acc:p33551]	12677.7	13941.7	1.0997
240	methyltransferase like 2. [refseq;acc:nm_018396]	17946	16326	1.09923
241	secreted modular calcium-binding protein 1. [refseq;acc:nm_022137]	14003.7	12743.3	1.09891
246	keratin associated protein 4.3 (fragment). [sptrembl;acc:q9byr4]	10551.6	11573.7	1.09687
247	keratin associated protein 2-4; keratin associated protein 2.4. [refseq;acc:nm_033184]
248	keratin associated protein 1.5. [refseq;acc:nm_031957]
249	keratin, ultra high-sulfur matrix protein a (uhs keratin a) (uhs kera). [swissprot;acc:p26371]
250	keratin associated protein 1-3; keratin associated protein 1.3. [refseq;acc:nm_030966]
251	keratin associated protein 4-10; keratin associated protein 4.10. [refseq;acc:nm_033060]		11573.6	1.09686
252	keratin associated protein 4-14; keratin associated protein 4.14. [refseq;acc:nm_033059]		11573.5	1.09685
253	keratin associated protein 4.9 (fragment). [sptrembl;acc:q9byq8]
254	keratin associated protein 4-12; keratin associated protein 4.12. [refseq;acc:nm_031854]
257	keratin associated protein 9-4; keratin associated protein 9.4. [refseq;acc:nm_033191]	10552.2	11566.4	1.09611
258	40s ribosomal protein s28. [swissprot;acc:p25112]	12967.1	14193.6	1.09459
261	40s ribosomal protein s4, x isoform (single copy abundant mrna protein) (scr10). [swissprot;acc:p12750]	12448.9	11393.9	1.09259
262	sirtuin 7; sir2-related protein type 7; sirtuin type 7; sirtuin (silent mating type information regulation 2, s.cerevisiae, homolog) 7; silent mating type information regulation 2, s.cerevisiae, homolog 7; sirtuin silent mating type information regulation 2 homolog 7 (s. cerevisiae). [refseq;acc:nm_016538]	3464	3778	1.09065
264	arsenical pump-driving atpase (ec 3.6.3.16) (arsenite-translocating atpase) (arsenical resistance atpase) (arsenite-transporting atpase) (arsa) (asna-i). [swissprot;acc:o43681]	10037.1	10935.1	1.08947
266	transcription factor btf3 homolog 3. [swissprot;acc:q13892]	13483.3	14685.4	1.08915
269	ischemia/reperfusion inducible protein. [refseq;acc:nm_024640]	12463.5	11482.6	1.08542
271	myosin light chain 1, embryonic muscle/atrial isoform (pro1957). [swissprot;acc:p12829]	10735.1	9891.37	1.0853
272	sterol regulatory element binding protein-2 (srebp-2) (sterol regulatory element-binding transcription factor 2). [swissprot;acc:q12772]	7163.55	7759.61	1.08321
274	disks large-associated protein 2 (dap-2) (sap90/psd-95-associated protein 2) (sapap2) (psd-95/sap90 binding protein 2) (fragment). [swissprot;acc:q9p1a6]	10432.4	11298.4	1.08301
276	60s ribosomal protein l9. [swissprot;acc:p32969]	10741.6	9922.33	1.08257
277	60s ribosomal protein l17 (l23). [swissprot;acc:p18621]	11096.8	10251.6	1.08245
281	phospholipid scramblase 3 (pl scramblase 3) (ca(2+)-dependent phospholipid scramblase 3). [swissprot;acc:q9nry6]	12522.7	13514.5	1.0792
285	dj408b20.3 (novel protein similar to 60s acidic ribosomal protein p2 (rplp2)). [sptrembl;acc:q9h5a9]	10686	9925.58	1.07661
287	proto-oncogene tyrosine-protein kinase src (ec 2.7.1.112) (p60-src) (c-src). [swissprot;acc:p12931]	17842.7	16590.3	1.07549
290	interleukin-1 receptor-associated kinase 4; interleukin-1 receptor associated kinase 4. [refseq;acc:nm_016123]	15147.2	14091.9	1.07489
292	ran-binding protein 2-like 1 isoform 2; sperm membrane protein bs-63; ran-binding protein 2-like 1. [refseq;acc:nm_032260]	10280.5	9574.98	1.07368
293		10287.1	9583.27	1.07344
295	transcription factor-like protein morf4 (mortality factor 4) (cellular senescence-related protein 1) (sen1). [swissprot;acc:q9y690]	13687.7	12751.8	1.07339
296	lon protease homolog, mitochondrial precursor (ec 3.4.21.-) (lon protease-like protein) (lonp) (lonhs). [swissprot;acc:p36776]	10194.1	10941.8	1.07335
298	40s ribosomal protein sa (p40) (34/67 kda laminin receptor) (colon carcinoma laminin-binding protein) (nem/1chd4) (multidrug resistance- associated protein mgr1-ag). [swissprot;acc:p08865]	11977.8	12842.5	1.07219
299	3 beta-hydroxysteroid dehydrogenase (fragments). [sptrembl;acc:q9udk8]	12338.7	11512.3	1.07178
302	guanine nucleotide-binding protein beta subunit-like protein 12.3 (p205) (receptor of activated protein kinase c 1) (rack1) (receptor for activated c kinase). [swissprot;acc:p25388]	7386.71	6895.44	1.07125
303	intersectin 2 (sh3 domain-containing protein 1b) (sh3p18) (sh3p18-like wasp associated protein). [swissprot;acc:q9nzm3]	11431.4	12244.1	1.07109
304	sprouty homolog 4 (spry-4). [swissprot;acc:q9c004]	8021.78	7496.8	1.07003
305	microtubule-interacting protein that associates with traf3; interleukin 13 receptor alpha 1-binding protein-1. [refseq;acc:nm_015650]	9431	8815	1.06988
307	ba271b5.1 (similar to ribosomal protein s7). [sptrembl;acc:q9h1s9]	1091	1021	1.06856
308	intersectin 1 (sh3 domain-containing protein 1a) (sh3p17). [swissprot;acc:q15811]	11414.1	12191.8	1.06814
310	glycine cleavage system h protein, mitochondrial precursor. [swissprot;acc:p23434]	9328.78	8741.55	1.06718

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.