MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Gene	description	Rank	Hugo	Value Type	Network Comparison Type	Interaction Map	red	Filtered	green	network_comparison

Results: HTML CSV LaTeX

Showing element 2601 to 2650 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

description	Rank	Hugo	Network Comparison Type	red	green	network_comparison
histone h2b.c (h2b/c). [swissprot;acc:q99880]	523	HIST1H2BL	Subtracted	247.47	233.441	14.029
	605		Divided			1.0601
histone h2b.d (h2b/d). [swissprot;acc:q99877]	528	no value	Subtracted			14.029
	610		Divided			1.0601
histone h2b.e (h2b/e). [swissprot;acc:q99879]	531		Subtracted			14.029
	613		Divided			1.0601
histone h2b.q (h2b/q) (h2b-gl105). [swissprot;acc:q16778]	524	HIST2H2BA	Subtracted			14.029
	606		Divided			1.0601
histone h2b.s (h2b/s). [swissprot;acc:p57053]	527	no value	Subtracted			14.029
	609		Divided			1.0601
histone h3.1 (h3/a) (h3/c) (h3/d) (h3/f) (h3/h) (h3/i) (h3/j) (h3/k) (h3/l). [swissprot;acc:p16106]	525		Subtracted			14.029
	607		Divided			1.0601
histone h3.3 (h3.a) (h3.b) (h3.3q). [swissprot;acc:p06351]	640		Subtracted	244.842	232.577	12.265
	723		Divided			1.05274
histone h3.4 (h3t) (h3/t) (h3/g). [swissprot;acc:q16695]	529	HIST3H3	Subtracted	247.47	233.441	14.029
	611		Divided			1.0601
histone h4. [swissprot;acc:p02304]	916	no value	Subtracted	227.765	219.902	7.863
	946		Divided			1.03576
histone-lysine n-methyltransferase, h3 lysine-9 specific 1 (ec 2.1.1.43) (histone h3-k9 methyltransferase 1) (h3-k9-hmtase 1) (suppressor of variegation 3-9 homolog 1) (su(var)3-9 homolog 1). [swissprot;acc:o43463]	1270	SUV39H1	Subtracted	226.433	231.491	5.058
	1342		Divided			1.02234
histone-lysine n-methyltransferase, h3 lysine-9 specific 2 (ec 2.1.1.43) (histone h3-k9 methyltransferase 2) (h3-k9-hmtase 2) (suppressor of variegation 3-9 homolog 2) (su(var)3-9 homolog 2). [swissprot;acc:q9h5i1]	1268	SUV39H2	Subtracted			5.058
	1340		Divided			1.02234
hiv tat specific factor 1; cofactor required for tat activation of hiv-1 transcription. [refseq;acc:nm_014500]	593	HTATSF1	Subtracted	217.67	230.596	12.926
	645		Divided			1.05938
hiv-1 rev binding protein 2; rev interacting protein. [refseq;acc:nm_007043]	1404	KRR1	Subtracted	242.181	237.834	4.347
	1503		Divided			1.01828
hiv-1 rev binding protein-like; rev/rex activation domain binding protein-related. [refseq;acc:nm_006076]	591	HRBL	Subtracted	217.67	230.596	12.926
	643		Divided			1.05938
hiv-1 tat interactive protein 2, 30kda; tat-interacting protein (30kd); hiv-1 tat interactive protein 2, 30 kda; hiv-1 tat interactive protein 2, 30 kd. [refseq;acc:nm_006410]	1613	HTATIP2		182.378	185.241	1.0157
	1701		Subtracted			2.863
hmg2 like. [refseq;acc:nm_145205]	2799	HMGB4	Divided	0.00001	0.00001	1
			Subtracted	0	0	0
homeobox prospero-like protein prox1 (prox 1). [swissprot;acc:q92786]	2194	PROX1	Divided	209.54	208.162	1.00662
	2209		Subtracted			1.378
homeobox protein barh-like 1. [swissprot;acc:q9hbu1]	499	BARX1		237.28	252.492	15.212
	582		Divided			1.06411
homeobox protein barh-like 2. [swissprot;acc:q9umq3]	504	BARX2	Subtracted			15.212
	587		Divided			1.06411
homeobox protein cux-2 (cut-like 2) (fragment). [swissprot;acc:o14529]	557	CUTL2		207.272	194.371	1.06637
	604		Subtracted			12.901
homeobox protein dlx-2. [swissprot;acc:q07687]	2313	DLX2		229.258	230.294	1.036
	2337		Divided			1.00452
homeobox protein dlx-3. [swissprot;acc:o60479]	2316	DLX3	Subtracted			1.036
	2340		Divided			1.00452
homeobox protein dlx-5. [swissprot;acc:p56178]	2314	DLX5	Subtracted			1.036
	2338		Divided			1.00452
homeobox protein engrailed-2 (hu-en-2). [swissprot;acc:p19622]	1135	EN2	Subtracted	219.399	213.784	5.615
	1167		Divided			1.02626
homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774]	1	HLX	Subtracted	215	322	107
	7		Divided			1.49767

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.