MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	Network Comparison Type	description	Value Type	Interaction Map	Filtered	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 425 to 474 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	Hugo	Network Comparison Type	description	red	network_comparison	green
213	HNRNPR	Subtracted	heterogeneous nuclear ribonucleoprotein r (hnrnp r). [swissprot;acc:o43390]	237.302	24.892	212.41
	PLDN	Divided	pallidin; pallid (mouse) homolog, pallidin. [refseq;acc:nm_012388]	210.693	1.127	186.95
214	LASS2		lag1 longevity assurance homolog 2 isoform 1; l3 pigment; tumor metastasis-suppressor. [refseq;acc:nm_022075]	191.644	1.12605	170.192
	MRPL4	Subtracted	mitochondrial ribosomal protein l4 isoform a. [refseq;acc:nm_015956]	241.282	24.838	266.12
215	no value	Divided	myosin heavy chain, cardiac muscle alpha isoform (myhc-alpha). [swissprot;acc:p13533]	112	1.125	126
	EIF4G1	Subtracted	eukaryotic translation initiation factor 4 gamma (eif-4-gamma) (eif- 4g) (eif4g) (p220). [swissprot;acc:q04637]	237.292	24.835	212.457
216	MYH4	Divided	myosin heavy chain, skeletal muscle, fetal (myosin heavy chain iib) (myhc-iib). [swissprot;acc:q9y623]	112	1.125	126
	SNRPD2	Subtracted	small nuclear ribonucleoprotein sm d2 (snrnp core protein d2) (sm-d2). [swissprot;acc:p43330]	226.471	24.702	201.769
217	MYH8	Divided	myosin heavy chain, skeletal muscle, perinatal (myhc-perinatal). [swissprot;acc:p13535]	112	1.125	126
	RPL26	Subtracted	60s ribosomal protein l26. [swissprot;acc:q02877]	242.326	24.682	267.008
218	MYH2	Divided	myosin heavy chain, skeletal muscle, adult 2 (myosin heavy chain iia) (myhc-iia). [swissprot;acc:q9ukx2]	112	1.125	126
	RPL35	Subtracted	60s ribosomal protein l35. [swissprot;acc:p42766]	242.333	24.666	266.999
219	no value		40s ribosomal protein s15 (rig protein). [swissprot;acc:p11174]	242.339	24.647	266.986
	MYH3	Divided	myosin heavy chain, fast skeletal muscle, embryonic (muscle embryonic myosin heavy chain) (smhce). [swissprot;acc:p11055]	112	1.125	126
220	MRPL2	Subtracted	mitochondrial ribosomal protein l2. [refseq;acc:nm_015950]	242.339	24.647	266.986
	MYH1	Divided	myosin heavy chain, skeletal muscle, adult 1 (myosin heavy chain iix/d) (myhc-iix/d). [swissprot;acc:p12882]	112	1.125	126
221	no value		myosin heavy chain, cardiac muscle beta isoform (myhc-beta). [swissprot;acc:p12883]
	EIF1B	Subtracted	protein translation factor sui1 homolog gc20. [swissprot;acc:o60739]	242.627	24.524	267.151
222	no value		60s ribosomal protein l14 (cag-isl 7). [swissprot;acc:p50914]	242.153	24.52	266.673
	MYH7B	Divided	dj756n5.1.1 (continues in em:al133324 as dj1161h23.3) (fragment). [sptrembl;acc:q9h430]	112	1.125	126
223	MYH13		myosin heavy chain, skeletal muscle, extraocular (myhc-eo). [swissprot;acc:q9ukx3]
	SRR	Subtracted	serine racemase (ec 5.1.1.-). [swissprot;acc:q9gzt4]	242.153	24.52	266.673
224	RPL34		60s ribosomal protein l34. [swissprot;acc:p49207]
	SLC15A2	Divided	oligopeptide transporter, kidney isoform (peptide transporter 2) (kidney h+/peptide cotransporter) (solute carrier family 15, member 2). [swissprot;acc:q16348]	185.969	1.12285	165.623
225	SEC61A2	Subtracted	protein transport protein sec61 alpha subunit isoform 2 (sec61 alpha- 2). [swissprot;acc:q9y2r3]	242.153	24.52	266.673
	SNRPD2	Divided	small nuclear ribonucleoprotein sm d2 (snrnp core protein d2) (sm-d2). [swissprot;acc:p43330]	226.471	1.12243	201.769
226	COMP		cartilage oligomeric matrix protein precursor (comp). [swissprot;acc:p49747]	239.991	1.12187	269.238
	SEC61A1	Subtracted	protein transport protein sec61 alpha subunit isoform 1 (sec61 alpha- 1). [swissprot;acc:p38378]	242.153	24.52	266.673
227	METAP1		methionine aminopeptidase 1 (ec 3.4.11.18) (metap 1) (map 1) (peptidase m 1). [swissprot;acc:p53582]	244.126	24.478	268.604
	THBS3	Divided	thrombospondin 3 precursor. [swissprot;acc:p49746]	239.99	1.12186	269.234
228	METAP2	Subtracted	methionine aminopeptidase 2 (ec 3.4.11.18) (metap 2) (peptidase m 2) (initiation factor 2 associated 67 kda glycoprotein) (p67) (p67eif2). [swissprot;acc:p50579]	244.126	24.478	268.604
	SH2D3C	Divided	sh2 domain containing 3c; novel sh2-containing protein 3; sh2 domain-containing 3c; likely ortholog of mouse cas/hef1-associated signal transducer. [refseq;acc:nm_005489]	226.411	1.12036	202.088
229	BCAR3		breast cancer antiestrogen resistance 3. [refseq;acc:nm_003567]	226.401	1.12028	202.094
	RPL3L	Subtracted	60s ribosomal protein l3-like. [swissprot;acc:q92901]	242.195	24.468	266.663
230	CSRP1	Divided	cysteine-rich protein 1 (crp1) (crp). [swissprot;acc:p21291]	239.35	1.11934	267.915
	EIF1	Subtracted	protein translation factor sui1 homolog (sui1iso1). [swissprot;acc:p41567]	242.694	24.323	267.017
231	SH2D3C		sh2 domain containing 3c; novel sh2-containing protein 3; sh2 domain-containing 3c; likely ortholog of mouse cas/hef1-associated signal transducer. [refseq;acc:nm_005489]	226.411		202.088
	SHCBP1	Divided	likely ortholog of mouse shc sh2-domain binding protein 1. [refseq;acc:nm_024745]	239.336	1.11927	267.881
232	BCAR3	Subtracted	breast cancer antiestrogen resistance 3. [refseq;acc:nm_003567]	226.401	24.307	202.094
	CSRP2	Divided	smooth muscle cell lim protein (cysteine-rich protein 2) (crp2) (lim-only protein 5). [swissprot;acc:q16527]	239.336	1.11926	267.879
233	no value	Subtracted	60s ribosomal protein l7. [swissprot;acc:p18124]	235.727	24.257	259.984
	CSRP3	Divided	lim domain protein, cardiac (muscle lim protein) (cysteine-rich protein 3) (crp3). [swissprot;acc:p50461]	239.32	1.11918	267.842
234	CHRAC1		chromatin accessibility complex protein 1 (chrac-1) (chrac-15) (huchrac15) (dna polymerase epsilon subunit p15). [swissprot;acc:q9nrg0]	287.41	1.11905	256.835
	RPS23	Subtracted	40s ribosomal protein s23. [swissprot;acc:p39028]	243.944	24.251	268.195
235	MRPS12		28s ribosomal protein s12, mitochondrial precursor (mpr-s12) (mt- rps12). [swissprot;acc:o15235]
	PAH	Divided	phenylalanine-4-hydroxylase (ec 1.14.16.1) (pah) (phe-4- monooxygenase). [swissprot;acc:p00439]	227.357	1.11785	254.15
236	DUS1L		pp3111 protein. [refseq;acc:nm_022156]
	RBBP7	Subtracted	histone acetyltransferase type b subunit 2 (retinoblastoma binding protein p46) (retinoblastoma-binding protein 7) (rbbp-7). [swissprot;acc:q16576]	252.644	24.224	228.42
237	MRPL3		mitochondrial 60s ribosomal protein l3 (l3mt). [swissprot;acc:p09001]	242.011	24.169	266.18
	STX18	Divided	syntaxin 18. [swissprot;acc:q9p2w9]	227.357	1.11785	254.15

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.