MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Value Type	Rank	Gene	description	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 6036 to 6085 of 29840 in total

Value Type  : Measured
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Network Comparison Type	red	green	network_comparison
2516	eh-domain containing protein 4 (eh domain-containing protein fksg7) (hepatocellular carcinoma-associated protein 10/11). [swissprot;acc:q9h223]	Divided	6203.95	6360.24	1.02519
2517	activator of camp-responsive element modulator (crem) in testis; lim protein act. [refseq;acc:nm_020482]	Subtracted	3669.33	3797.78	128.45
	eh-domain containing protein 2. [swissprot;acc:q9nzn4]	Divided	6203.96	6360.24	1.02519
2518	chromobox protein homolog 3 (heterochromatin protein 1 homolog gamma) (hp1 gamma) (modifier 2 protein) (hech). [swissprot;acc:q13185]	Subtracted	7550.12	7422.01	128.11
	sin3 associated polypeptide p18 (2hor0202). [swissprot;acc:o00422]	Divided	6204.15	6360.27	1.02516
2519	adenine phosphoribosyltransferase (ec 2.4.2.7) (aprt). [swissprot;acc:p07741]		5964.17	6113.96	1.02511
	putative eukaryotic translation initiation factor 1a (eif-1a) (eif- 4c). [swissprot;acc:o75642]	Subtracted	3754.39	3629.51	124.88
2520	40s ribosomal protein s14 (pro2640). [swissprot;acc:p06366]		3708.67	3584.47	124.2
	estradiol 17 beta-dehydrogenase 1 (ec 1.1.1.62) (17-beta-hsd 1) (placental 17-beta-hydroxysteroid dehydrogenase) (20 alpha- hydroxysteroid dehydrogenase) (20-alpha-hsd) (e2dh). [swissprot;acc:p14061]	Divided	5964.17	6113.96	1.02511
2521	17 beta-hydroxysteroid dehydrogenase. [sptrembl;acc:q13034]
	40s ribosomal protein s18 (ke-3) (ke3). [swissprot;acc:p25232]	Subtracted	3708.67	3584.47	124.2
2522	apoptosis inhibitor fksg2. [swissprot;acc:q9hau6]		7181.3	7057.99	123.31
	retinol dehydrogenase 8 (all-trans); photoreceptor outer segment all-trans retinol dehydrogenase. [refseq;acc:nm_015725]	Divided	5964.17	6113.96	1.02511
2523	dna-directed rna polymerase i 40 kda polypeptide (ec 2.7.7.6) (rpa40) (rpa39). [swissprot;acc:o15160]		3803.04	3710.01	1.02508
	skeletal muscle lim-protein 2 (slim 2) (four and a half lim domains protein 3) (fhl-3). [swissprot;acc:q13643]	Subtracted	3634.59	3756.67	122.08
2524	myo-inositol 1-phosphate synthase a1. [refseq;acc:nm_016368]	Divided	8695.15	8912.98	1.02505
	skeletal muscle lim-protein 3 (slim 3) (lim-domain protein dral) (four and a half lim domains protein 2) (fhl-2). [swissprot;acc:q14192]	Subtracted	3633.14	3754.96	121.82
2525	arsenical pump-driving atpase (ec 3.6.3.16) (arsenite-translocating atpase) (arsenical resistance atpase) (arsenite-transporting atpase) (arsa) (asna-i). [swissprot;acc:o43681]	Divided	8695.15	8912.98	1.02505
	translationally controlled tumor protein (tctp) (p23) (histamine- releasing factor) (hrf). [swissprot;acc:p13693]	Subtracted	7169.01	7047.98	121.03
2526	chromobox protein homolog 1 (heterochromatin protein 1 homolog beta) (hp1 beta) (modifier 1 protein) (m31) (heterochromatin protein p25). [swissprot;acc:p23197]		7538.48	7417.58	120.9
	ubiquitin-like protein gdx (ubiquitin-like protein 4). [swissprot;acc:p11441]	Divided	8695.15	8912.98	1.02505
2527	60s ribosomal protein l13, mitochondrial (l13mt). [swissprot;acc:q9byd1]	Subtracted	3730.53	3611.05	119.48
	large proline-rich protein bat3 (hla-b-associated transcript 3) (g3). [swissprot;acc:p46379]	Divided	8695.15	8912.98	1.02505
2528	40s ribosomal protein s16. [swissprot;acc:p17008]	Subtracted	3730.53	3611.05	119.48
	reticulon 4 (neurite outgrowth inhibitor) (nogo protein) (foocen) (neuroendocrine-specific protein) (nsp) (neuroendocrine specific protein c homolog) (rtn-x) (reticulon 5) (my043 protein). [swissprot;acc:q9nqc3]	Divided	6205.14	6359.44	1.02487
2529	60s ribosomal protein l13a (23 kda highly basic protein). [swissprot;acc:p40429]	Subtracted	3730.74	3611.45	119.29
	protein cgi-147. [swissprot;acc:q9y3e5]	Divided	6436.43	6283	1.02442
2530	28s ribosomal protein s9, mitochondrial precursor (mrp-s9). [swissprot;acc:p82933]		3880.5	3788.42	1.02431
	60s ribosomal protein l15. [swissprot;acc:p39030]	Subtracted	4888.72	5006.1	117.38
2531	lim/homeobox protein lhx3. [swissprot;acc:q9ubr4]		7571.73	7688.39	116.66
	polymyositis/scleroderma autoantigen 2 (autoantigen pm/scl 2) (polymyositis/scleroderma autoantigen 100 kda) (pm/scl-100) (p100 polymyositis-scleroderma overlap syndrome associated autoantigen). [swissprot;acc:q01780]	Divided	6141.97	6291.08	1.02428
2532	60s ribosomal protein l15. [swissprot;acc:p39030]		4888.72	5006.1	1.02401
	lim domain binding 2; lim binding domain 2; lim domain-binding factor-2. [refseq;acc:nm_001290]	Subtracted	7572.69	7689.04	116.35
2533	dna-directed rna polymerase i 135 kda polypeptide (ec 2.7.7.6) (rna polymerase i subunit 2) (rpa135). [swissprot;acc:q9h9y6]	Divided	3847.84	3759.28	1.02356
	lim domain binding 1; carboxy terminal lim domain protein 2; lim domain-binding factor-1. [refseq;acc:nm_003893]	Subtracted	7572.7	7689.04	116.34
2534	lim/homeobox protein lhx4. [swissprot;acc:q969g2]		7573.83	7689.81	115.98
	thyroid receptor interacting protein 12 (trip12). [swissprot;acc:q14669]	Divided	6452.33	6603.94	1.0235
2535	dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial precursor (ec 2.3.1.61) (e2) (e2k). [swissprot;acc:p36957]
	rad50 homolog isoform 1. [refseq;acc:nm_005732]	Subtracted	7222.12	7110.74	111.38
2536	insulin gene enhancer protein isl-1 (islet-1). [swissprot;acc:p20663]		7424.26	7534.05	109.79
	sorting nexin 1. [swissprot;acc:q13596]	Divided	5932.05	6071.35	1.02348
2537	mevalonate kinase (ec 2.7.1.36) (mk). [swissprot;acc:q03426]	Subtracted	4243.44	4352.56	109.12
	pyruvate dehydrogenase e1 component alpha subunit, testis-specific form, mitochondrial precursor (ec 1.2.4.1) (pdhe1-a type ii). [swissprot;acc:p29803]	Divided	6669.22	6824.41	1.02327
2538	estradiol 17 beta-dehydrogenase 4 (ec 1.1.1.62) (17-beta-hsd 4) (17-beta-hydroxysteroid dehydrogenase 4). [swissprot;acc:p51659]		7121.07	7286.61	1.02325
	zinc finger protein 444; endothelial zinc finger protein 2. [refseq;acc:nm_018337]	Subtracted	3573.66	3682.14	108.48
2539	maleylacetoacetate isomerase (ec 5.2.1.2) (maai) (glutathione s- transferase zeta 1) (ec 2.5.1.18) (gstz1-1). [swissprot;acc:o43708]		3626.38	3734.8	108.42
	ubiquinol-cytochrome c reductase iron-sulfur subunit, mitochondrial precursor (ec 1.10.2.2) (rieske iron-sulfur protein) (risp). [swissprot;acc:p47985]	Divided	3805.17	3718.86	1.02321
2540	osteoclast stimulating factor 1. [swissprot;acc:q92882]	Subtracted	4708.98	4817.39	108.41
	pyruvate dehydrogenase e1 component alpha subunit, somatic form, mitochondrial precursor (ec 1.2.4.1) (pdhe1-a type i). [swissprot;acc:p08559]	Divided	6672.69	6827.51	1.0232
2541	tata box binding protein-associated factor, rna polymerase ii, q; taf7-like rna polymerase ii, tata box binding protein (tbp)-associated factor, 50 kd; tbp-associated factor, rna polymerase ii, q. [refseq;acc:nm_024885]		8542.13	8740.23	1.02319

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.