MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Value Type	Gene	description	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 2525 to 2574 of 12912 in total

Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

Rank	Value Type	description	red	green	network_comparison
632	Measured	disks large-associated protein 2 (dap-2) (sap90/psd-95-associated protein 2) (sapap2) (psd-95/sap90 binding protein 2) (fragment). [swissprot;acc:q9p1a6]	6228.39	7013.19	1.126
	Ranked	homeobox protein hox-d9 (hox-4c) (hox-5.2). [swissprot;acc:p28356]	214.254	202.166	1.05979
	Squared	phosphatidylserine receptor; phosphatidylserine receptor beta. [refseq;acc:nm_015167]	32192.5	37966.8	1.17937
	Rooted	actin binding lim protein 2. [refseq;acc:nm_032432]	60.0129	64.7371	1.07872
633	Measured	ferritin light chain (ferritin l subunit). [swissprot;acc:p02792]	6228.39	7013.19	1.126
	Ranked	alanyl-trna synthetase (ec 6.1.1.7) (alanine--trna ligase) (alars). [swissprot;acc:p49588]	234.106	248.104	1.05979
	Squared	gamma-aminobutyric-acid receptor alpha-1 subunit precursor (gaba(a) receptor). [swissprot;acc:p14867]	32192.8	37967.2	1.17937
	Rooted	hairy/enhancer-of-split related with yrpw motif-like. [refseq;acc:nm_014571]	60.0129	64.7371	1.07872
634	Measured	disks large-associated protein 4 (dap-4) (sap90/psd-95-associated protein 4) (sapap4) (psd-95/sap90 binding protein 4). [swissprot;acc:q9y2h0]	6228.39	7013.19	1.126
	Ranked	dead-box protein abstrakt homolog. [swissprot;acc:q9ujv9]	226.523	213.786	1.05958
	Squared	gamma-aminobutyric-acid receptor alpha-3 subunit precursor (gaba(a) receptor). [swissprot;acc:p34903]	32192.8	37967.1	1.17937
	Rooted	synapsin ii. [swissprot;acc:q92777]	60.0129	64.7371	1.07872
635	Measured	ferritin heavy polypeptide-like 17. [swissprot;acc:q9bxu8]	6228.97	7013.53	1.12595
	Ranked	60s ribosomal protein l37 (g1.16). [swissprot;acc:p02403]	228.639	242.258	1.05957
	Squared	homeobox protein hox-c9 (hox-3b). [swissprot;acc:p31274]	32189.9	37963.6	1.17936
	Rooted	mitochondrial ribosome recycling factor. [refseq;acc:nm_138777]	60.0129	64.7371	1.07872
636	Measured	proteasome subunit alpha type 5 (ec 3.4.25.1) (proteasome zeta chain) (macropain zeta chain) (multicatalytic endopeptidase complex zeta chain). [swissprot;acc:p28066]	5713.41	6432.92	1.12593
	Ranked	splicing factor, arginine/serine-rich 1 (pre-mrna splicing factor sf2, p33 subunit) (alternative splicing factor asf-1). [swissprot;acc:q07955]	228.639	242.258	1.05957
	Squared	homeobox protein hox-b9 (hox-2e) (hox-2.5). [swissprot;acc:p17482]	32187.7	37961	1.17936
	Rooted	peroxisomal targeting signal 1 receptor (peroxismore receptor 1) (peroxisomal c-terminal targeting signal import receptor) (pts1-bp) (peroxin-5) (pts1 receptor). [swissprot;acc:p50542]	60.0129	64.7371	1.07872
637	Measured	putative nucleoside diphosphate kinase (ec 2.7.4.6) (ndk) (ndp kinase). [swissprot;acc:o60361]	7756.51	8731.76	1.12573
	Ranked	amidophosphoribosyltransferase precursor (ec 2.4.2.14) (glutamine phosphoribosylpyrophosphate amidotransferase) (atase) (gpat). [swissprot;acc:q06203]	228.639	242.258	1.05957
	Squared	homeobox protein hox-a9 (hox-1g). [swissprot;acc:p31269]	32188.2	37961.6	1.17936
	Rooted	hairy/enhancer-of-split related with yrpw motif 2; gridlock; hes-related repressor protein 1. [refseq;acc:nm_012259]	60.0129	64.7371	1.07872
638	Measured	nucleoside diphosphate kinase a (ec 2.7.4.6) (ndk a) (ndp kinase a) (tumor metastatic process-associated protein) (metastasis inhibition factor nm23) (nm23-h1). [swissprot;acc:p15531]	7755.69	8730.74	1.12572
	Ranked	sorting nexin 17. [swissprot;acc:q15036]	228.639	242.258	1.05957
	Squared	homeobox protein hox-a10 (hox-1h) (hox-1.8) (pl). [swissprot;acc:p31260]	32183.5	37955.7	1.17935
	Rooted	transcription factor hes-1 (hairy and enhancer of split 1) (hairy- like) (hhl) (hairy homolog). [swissprot;acc:q14469]	60.0129	64.7371	1.07872
639	Measured	nucleoside diphosphate kinase b (ec 2.7.4.6) (ndk b) (ndp kinase b) (nm23-h2) (c-myc purine-binding transcription factor puf). [swissprot;acc:p22392]	7753.59	8728.13	1.12569
	Ranked	nucleoporin-like protein rip (hiv-1 rev-binding protein) (rev interacting protein) (rev/rex activation domain-binding protein). [swissprot;acc:p52594]	217.67	230.596	1.05938
	Squared	bag-family molecular chaperone regulator-3 (bcl-2 binding athanogene- 3) (bag-3) (bcl-2-binding protein bis) (docking protein cair-1). [swissprot;acc:o95817]	17618.8	20776.8	1.17924
	Rooted	delta3,5-delta2,4-dienoyl-coa isomerase, mitochondrial precursor (ec 5.3.3.-). [swissprot;acc:q13011]	60.0129	64.7371	1.07872
640	Measured	glutathione s-transferase theta 2 (ec 2.5.1.18) (gst class-theta). [swissprot;acc:p30712]	4811.02	5414.64	1.12547
	Ranked	intersectin 1 (sh3 domain-containing protein 1a) (sh3p17). [swissprot;acc:q15811]	217.67	230.596	1.05938
	Squared	nicotinate-nucleotide pyrophosphorylase [carboxylating] (ec 2.4.2.19) (quinolinate phosphoribosyltransferase [decarboxylating]) (qaprtase) (qprtase). [swissprot;acc:q15274]	22848.5	26941.5	1.17914
	Rooted	actin-binding lim protein 1 isoform a; lim actin-binding protein 1; limatin; actin-binding lim protein. [refseq;acc:nm_002313]	60.0129	64.7371	1.07872
641	Measured	peroxisomal n1-acetyl-spermine/spermidine oxidase. [refseq;acc:nm_152911]	4810.85	5414.21	1.12542
	Ranked	pram-1 protein; pml-rara target gene encoding an adaptor molecule-1. [refseq;acc:nm_032152]	217.67	230.596	1.05938
	Squared	u6 snrna-associated sm-like protein lsm7. [swissprot;acc:q9uk45]	18364.9	21653.8	1.17909
	Rooted	synapsin i (brain protein 4.1). [swissprot;acc:p17600]	60.0129	64.7371	1.07872
642	Measured	atpase inhibitor, mitochondrial precursor. [swissprot;acc:q9uii2]	4810.85	5414.23	1.12542
	Ranked	intersectin 2 (sh3 domain-containing protein 1b) (sh3p18) (sh3p18-like wasp associated protein). [swissprot;acc:q9nzm3]	217.67	230.596	1.05938
	Squared	6-phosphofructokinase, liver type (ec 2.7.1.11) (phosphofructokinase 1) (phosphohexokinase) (phosphofructo-1-kinase isozyme b) (pfk-b). [swissprot;acc:p17858]	16123.9	19009.7	1.17898
	Rooted	ponsin; sh3-domain protein 5 (ponsin). [refseq;acc:nm_015385]	64.4857	69.5606	1.0787
643	Measured	polyamine oxidase isoform 1; polyamine oxidase; flavin-containing spermine oxidase; putative cyclin g1 interacting protein; flavin containing amine oxidase. [refseq;acc:nm_019025]	4810.85	5414.23	1.12542
	Ranked	hiv-1 rev binding protein-like; rev/rex activation domain binding protein-related. [refseq;acc:nm_006076]	217.67	230.596	1.05938
	Squared	6-phosphofructokinase, muscle type (ec 2.7.1.11) (phosphofructokinase 1) (phosphohexokinase) (phosphofructo-1-kinase isozyme a) (pfk-a) (phosphofructokinase-m). [swissprot;acc:p08237]	16126.5	19012.6	1.17897
	Rooted	autophagy protein 12-like (apg12-like). [swissprot;acc:o94817]	87.4586	81.0798	1.07867
644	Measured	cytochrome c-type heme lyase (ec 4.4.1.17) (cchl) (holocytochrome c- type synthase). [swissprot;acc:p53701]	4810.85	5414.22	1.12542
	Ranked	cgthba protein (-14 gene protein). [swissprot;acc:q12980]	217.67	230.596	1.05938

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.